Retroviral oncoprotein Tax deregulates NF-kappaB by activating Tak1 and mediating the physical association of Tak1-IKK
about
The HTLV-1 Tax interactomeHighlights on distinctive structural and functional properties of HTLV Tax proteinsHelicobacter pylori CagA activates NF-kappaB by targeting TAK1 for TRAF6-mediated Lys 63 ubiquitinationHTLV-1 Infection and Adult T-Cell Leukemia/Lymphoma-A Tale of Two Proteins: Tax and HBZMolecular Studies of HTLV-1 Replication: An UpdateHTLV-1 Tax Functions as a Ubiquitin E3 Ligase for Direct IKK Activation via Synthesis of Mixed-Linkage Polyubiquitin ChainsModulation of NF-κB signalling by microbial pathogensTax-1 and Tax-2 similarities and differences: focus on post-translational modifications and NF-κB activation.HIV-1 Vpr stimulates NF-κB and AP-1 signaling by activating TAK1.TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesisHTLV-1 tax-induced rapid senescence is driven by the transcriptional activity of NF-κB and depends on chronically activated IKKα and p65/RelA.Role of post-translational modifications of HTLV-1 Tax in NF-κB activation.Acetylation of the c-MYC oncoprotein is required for cooperation with the HTLV-1 p30(II) accessory protein and the induction of oncogenic cellular transformation by p30(II)/c-MYC.Mutual regulation between deubiquitinase CYLD and retroviral oncoprotein TaxHuman T Lymphotropic Virus Type 1 (HTLV-1): Molecular Biology and Oncogenesis.HTLV-1 Tax Stimulates Ubiquitin E3 Ligase, Ring Finger Protein 8, to Assemble Lysine 63-Linked Polyubiquitin Chains for TAK1 and IKK Activation.The cytoplasmic domain of the HIV-1 glycoprotein gp41 induces NF-κB activation through TGF-β-activated kinase 1.FKBP51 employs both scaffold and isomerase functions to promote NF-κB activation in melanoma.HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63- and Met1-Linked Hybrid Polyubiquitin Chains.The human T-cell leukemia virus type 1 Tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-kappaB activation.HTLV tax: a fascinating multifunctional co-regulator of viral and cellular pathwaysDistinct Activation Mechanisms of NF-κB Regulator Inhibitor of NF-κB Kinase (IKK) by Isoforms of the Cell Death Regulator Cellular FLICE-like Inhibitory Protein (cFLIP).Ubiquitin in NF-kappaB signaling.NF-κB as a target for oncogenic viruses.Distinct functions of HTLV-1 Tax1 from HTLV-2 Tax2 contribute key roles to viral pathogenesis.Expanding role of ubiquitination in NF-κB signaling.Intracellular localization and cellular factors interaction of HTLV-1 and HTLV-2 Tax proteins: similarities and functional differences.New insight into the oncogenic mechanism of the retroviral oncoprotein Tax.Human T-lymphotropic virus proteins and post-translational modification pathwaysRegulation of HTLV-1 tax stability, cellular trafficking and NF-κB activation by the ubiquitin-proteasome pathway.TAK1 regulates NF-ΚB and AP-1 activation in airway epithelial cells following RSV infection.Human T cell lymphotropic virus 1 manipulates interferon regulatory signals by controlling the TAK1-IRF3 and IRF4 pathways.Macropinocytosis and TAK1 mediate anti-inflammatory to pro-inflammatory macrophage differentiation by HIV-1 NefA critical role for IL-17RB signaling in HTLV-1 tax-induced NF-κB activation and T-cell transformation.Phosphorylation and polyubiquitination of transforming growth factor beta-activated kinase 1 are necessary for activation of NF-kappaB by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor.NF-kappaB: Two Sides of the Same Coin.HTLV-1 Tax is a critical lipid raft modulator that hijacks IkappaB kinases to the microdomains for persistent activation of NF-kappaB.The TP53-Induced Glycolysis and Apoptosis Regulator mediates cooperation between HTLV-1 p30II and the retroviral oncoproteins Tax and HBZ and is highly expressed in an in vivo xenograft model of HTLV-1-induced lymphoma.
P2860
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P2860
Retroviral oncoprotein Tax deregulates NF-kappaB by activating Tak1 and mediating the physical association of Tak1-IKK
description
2007 nî lūn-bûn
@nan
2007 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Retroviral oncoprotein Tax der ...... ysical association of Tak1-IKK
@ast
Retroviral oncoprotein Tax der ...... ysical association of Tak1-IKK
@en
Retroviral oncoprotein Tax der ...... ysical association of Tak1-IKK
@en-gb
Retroviral oncoprotein Tax der ...... ysical association of Tak1-IKK
@nl
type
label
Retroviral oncoprotein Tax der ...... ysical association of Tak1-IKK
@ast
Retroviral oncoprotein Tax der ...... ysical association of Tak1-IKK
@en
Retroviral oncoprotein Tax der ...... ysical association of Tak1-IKK
@en-gb
Retroviral oncoprotein Tax der ...... ysical association of Tak1-IKK
@nl
prefLabel
Retroviral oncoprotein Tax der ...... ysical association of Tak1-IKK
@ast
Retroviral oncoprotein Tax der ...... ysical association of Tak1-IKK
@en
Retroviral oncoprotein Tax der ...... ysical association of Tak1-IKK
@en-gb
Retroviral oncoprotein Tax der ...... ysical association of Tak1-IKK
@nl
P2860
P3181
P356
P1433
P1476
Retroviral oncoprotein Tax der ...... ysical association of Tak1-IKK
@en
P2093
Shao-Cong Sun
Xuefeng Wu
P2860
P3181
P356
10.1038/SJ.EMBOR.7400931
P407
P577
2007-05-01T00:00:00Z