PERK is required in the adult pancreas and is essential for maintenance of glucose homeostasis. - Wikidata - awgldk - TriplyDB

PERK is required in the adult pancreas and is essential for maintenance of glucose homeostasis.

PERK is required in the adult pancreas and is essential for maintenance of glucose homeostasis.

http://www.wikidata.org/entity/Q36435206

about

The Role of Organelle Stresses in Diabetes Mellitus and Obesity: Implication for Treatment Oncogenes strike a balance between cellular growth and homeostasis Tumor progression and the different faces of the PERK kinase PERK Integrates Oncogenic Signaling and Cell Survival During Cancer Development Generation and characterization of an analog-sensitive PERK allele.New pharmacological perspectives for the leptin receptor in the treatment of obesity A new PERKspective on neurodegeneration.Protein-Binding Function of RNA-Dependent Protein Kinase Promotes Proliferation through TRAF2/RIP1/NF-κB/c-Myc Pathway in Pancreatic β cells Insulin demand regulates β cell number via the unfolded protein response.PERK Is a Haploinsufficient Tumor Suppressor: Gene Dose Determines Tumor-Suppressive Versus Tumor Promoting Properties of PERK in Melanoma.Type I interferons mediate pancreatic toxicities of PERK inhibition.Role of the unfolded protein response, GRP78 and GRP94 in organ homeostasis.miR-216b regulation of c-Jun mediates GADD153/CHOP-dependent apoptosis Unfolded protein response signaling and metabolic diseases.PPAR-γ Agonists As Antineoplastic Agents in Cancers with Dysregulated IGF Axis.Role of the unfolded protein response in β cell compensation and failure during diabetes.Molecular pathways: the PERKs and pitfalls of targeting the unfolded protein response in cancer.PDI is an essential redox-sensitive activator of PERK during the unfolded protein response (UPR)Protein misfolding in the endoplasmic reticulum as a conduit to human disease.Interplay between steroid hormone activation of the unfolded protein response and nuclear receptor action.Interaction of Nck1 and PERK phosphorylated at Y⁵⁶¹ negatively modulates PERK activity and PERK regulation of pancreatic β-cell proinsulin content.Targeting the unfolded protein response in cancer.Genetic inactivation of PERK signaling in mouse oligodendrocytes: normal developmental myelination with increased susceptibility to inflammatory demyelination.Discovery of GSK2656157: An Optimized PERK Inhibitor Selected for Preclinical Development.miR-204 Targets PERK and Regulates UPR Signaling and β-Cell Apoptosis.A PERK-miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival.PERK leads a hub dictating pancreatic β cell homoeostasis.Recent insights into PERK-dependent signaling from the stressed endoplasmic reticulum.Cross-Talk Between FSH and Endoplasmic Reticulum Stress: A Mutually Suppressive Relationship.The unfolded protein response mediates fibrogenesis and collagen I secretion through regulating TANGO1 in mice.Role of the unfolded protein response in organ physiology: lessons from mouse models.Translational attenuation and retinal degeneration in mice with an active integrated stress response.Acinar cell injury induced by inadequate unfolded protein response in acute pancreatitis Emerging Roles for Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) in Pancreatic Beta Cells and Diabetes

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PERK is required in the adult pancreas and is essential for maintenance of glucose homeostasis.

http://www.wikidata.org/entity/Q36435206

description

2012 nî lūn-bûn

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2012年の論文

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年學術文章

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2012年學術文章

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2012年學術文章

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name

PERK is required in the adult ...... enance of glucose homeostasis.

@ast

PERK is required in the adult ...... enance of glucose homeostasis.

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type

label

PERK is required in the adult ...... enance of glucose homeostasis.

@ast

PERK is required in the adult ...... enance of glucose homeostasis.

@en

prefLabel

PERK is required in the adult ...... enance of glucose homeostasis.

@ast

PERK is required in the adult ...... enance of glucose homeostasis.

@en

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Molecular and Cellular Biology

P1476

PERK is required in the adult ...... enance of glucose homeostasis.

@en

P2093

Changhong Li

http://www.w3.org/2001/XMLSchema#string

Daniel J Sartori

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J Alan Diehl

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Jake A Kushner

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M Celeste Simon

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Qian-Chun Yu

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Yan Gao

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P2860

Induction of human beta-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6

Endoplasmic reticulum stress and the inflammatory basis of metabolic disease

Apoptosis, oncosis, and necrosis. An overview of cell death

Perk is essential for translational regulation and cell survival during the unfolded protein response

PERK mediates cell-cycle exit during the mammalian unfolded protein response

Translational control is required for the unfolded protein response and in vivo glucose homeostasis

Wolcott-Rallison Syndrome: clinical, genetic, and functional study of EIF2AK3 mutations and suggestion of genetic heterogeneity

Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas

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5129-5139

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scholarly article

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10.1128/MCB.01009-12

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24

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32

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2012-10-15T00:00:00Z

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23071091

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Aizkuņģa dziedzeris

P932

3510549

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