A novel processive mechanism for DNA synthesis revealed by structure, modeling and mutagenesis of the accessory subunit of human mitochondrial DNA polymerase
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Structural insight into processive human mitochondrial DNA synthesis and disease-related polymerase mutationsThe EM structure of human DNA polymerase gamma reveals a localized contact between the catalytic and accessory subunitsMitochondrial disorders of DNA polymerase γ dysfunction: from anatomic to molecular pathology diagnosisStructure and function of the c-myc DNA-unwinding element-binding protein DUE-BDpb2p, a noncatalytic subunit of DNA polymerase epsilon, contributes to the fidelity of DNA replication in Saccharomyces cerevisiae.The role of mitochondrial DNA mutations in mammalian agingParallel multiplicative target screening against divergent bacterial replicases: identification of specific inhibitors with broad spectrum potentialAnalysis of enzyme kinetic data for mtDNA replication.A mechanistic view of human mitochondrial DNA polymerase gamma: providing insight into drug toxicity and mitochondrial diseaseFunctional analysis of H. sapiens DNA polymerase gamma spacer mutation W748S with and without common variant E1143G.Replication pauses of the wild-type and mutant mitochondrial DNA polymerase gamma: a simulation study.Defects of mitochondrial DNA replication.Biochemical analysis of human POLG2 variants associated with mitochondrial disease.Evolution of the metazoan mitochondrial replicase.Clustering of Alpers disease mutations and catalytic defects in biochemical variants reveal new features of molecular mechanism of the human mitochondrial replicase, Pol γ.Developing master keys to brain pathology, cancer and aging from the structural biology of proteins controlling reactive oxygen species and DNA repair.Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase γPOLG2 disease variants: analyses reveal a dominant negative heterodimer, altered mitochondrial localization and impaired respiratory capacity.Mitochondrial Single-stranded DNA-binding Proteins Stimulate the Activity of DNA Polymerase γ by Organization of the Template DNA.Biolayer Interferometry: A Novel Method to Elucidate Protein-Protein and Protein-DNA Interactions in the Mitochondrial DNA ReplisomeComparative purification strategies for Drosophila and human mitochondrial DNA replication proteins: DNA polymerase gamma and mitochondrial single-stranded DNA-binding proteinProgressive external ophthalmoplegia and vision and hearing loss in a patient with mutations in POLG2 and OPA1.Human mitochondrial DNA replication machinery and disease.The accessory subunit of mitochondrial DNA polymerase gamma determines the DNA content of mitochondrial nucleoids in human cultured cells.Mosaic origin of the mitochondrial proteome.Replicating animal mitochondrial DNA.Inherited mitochondrial genomic instability and chemical exposures.Whole exome sequencing identifies a homozygous POLG2 missense variant in an infant with fulminant hepatic failure and mitochondrial DNA depletion.The accessory subunit B of DNA polymerase gamma is required for mitochondrial replisome function.Mitochondrial diseases: the contribution of organelle stress responses to pathology.Analysis of mutant DNA polymerase gamma in patients with mitochondrial DNA depletion.Characterization of the human homozygous R182W POLG2 mutation in mitochondrial DNA depletion syndromeMitochondrial DNA replication in mammalian cells: overview of the pathway
P2860
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P2860
A novel processive mechanism for DNA synthesis revealed by structure, modeling and mutagenesis of the accessory subunit of human mitochondrial DNA polymerase
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh
2006年學術文章
@zh-hant
name
A novel processive mechanism f ...... n mitochondrial DNA polymerase
@ast
A novel processive mechanism f ...... n mitochondrial DNA polymerase
@en
type
label
A novel processive mechanism f ...... n mitochondrial DNA polymerase
@ast
A novel processive mechanism f ...... n mitochondrial DNA polymerase
@en
prefLabel
A novel processive mechanism f ...... n mitochondrial DNA polymerase
@ast
A novel processive mechanism f ...... n mitochondrial DNA polymerase
@en
P2093
P2860
P1476
A novel processive mechanism f ...... n mitochondrial DNA polymerase
@en
P2093
Carol L Farr
John A Tainer
Kathleen M Randolph
Kevin T Schaefer
Laurie S Kaguni
Sangbumn Kim
P2860
P304
P356
10.1016/J.JMB.2006.02.073
P407
P577
2006-03-15T00:00:00Z