Epigenetic silencing of the chaperone Cosmc in human leukocytes expressing tn antigen
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Functional Consequences of Differential O-glycosylation of MUC1, MUC4, and MUC16 (Downstream Effects on Signaling)Challenges in Antibody Development against Tn and Sialyl-Tn AntigensImmature truncated O-glycophenotype of cancer directly induces oncogenic featuresIdentification of distinct glycoforms of IgA1 in plasma from patients with immunoglobulin A (IgA) nephropathy and healthy individualsDNA methylation in Cosmc promoter region and aberrantly glycosylated IgA1 associated with pediatric IgA nephropathy.Protein glycosylation in cancer.Aberrant Cosmc genes result in Tn antigen expression in human colorectal carcinoma cell line HT-29.Promoters of Human Cosmc and T-synthase Genes Are Similar in Structure, Yet Different in Epigenetic RegulationAberrant Glycosylation in the Left Ventricle and Plasma of Rats with Cardiac Hypertrophy and Heart Failure.Cellular O-Glycome Reporter/Amplification to explore O-glycans of living cellsThe cytokine-cosmc signaling axis upregulates the tumor-associated carbohydrate antigen Tn.Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control AdenocarcinomaIdentification of a novel protein binding motif within the T-synthase for the molecular chaperone Cosmc.Tn and sialyl-Tn antigens, aberrant O-glycomics as human disease markers.Simple sugars to complex disease--mucin-type O-glycans in cancer.Biosynthetic Machinery Involved in Aberrant Glycosylation: Promising Targets for Developing of Drugs Against CancerCOSMC knockdown mediated aberrant O-glycosylation promotes oncogenic properties in pancreatic cancer.Multi-level regulation of cellular glycosylation: from genes to transcript to enzyme to structure.Acceptor specificities and selective inhibition of recombinant human Gal- and GlcNAc-transferases that synthesize core structures 1, 2, 3 and 4 of O-glycansMonoclonal antibodies toward different Tn-amino acid backbones display distinct recognition patterns on human cancer cells. Implications for effective immuno-targeting of cancer.Epigenetic Bases of Aberrant Glycosylation in Cancer.CDX2 homeoprotein is involved in the regulation of ST6GalNAc-I gene in intestinal metaplasia.Structural Insights into VLR Fine Specificity for Blood Group Carbohydrates.Expression of Mucin-1 in multiple myeloma and its precursors: correlation with glycosylation and subcellular localizationMultiple Roles of Glycans in Hematological MalignanciesDifferential expression of Cosmc, T-synthase and mucins in Tn-positive colorectal cancers
P2860
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P2860
Epigenetic silencing of the chaperone Cosmc in human leukocytes expressing tn antigen
description
2012 nî lūn-bûn
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2012年の論文
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2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年學術文章
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2012年學術文章
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2012年學術文章
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name
Epigenetic silencing of the chaperone Cosmc in human leukocytes expressing tn antigen
@ast
Epigenetic silencing of the chaperone Cosmc in human leukocytes expressing tn antigen
@en
type
label
Epigenetic silencing of the chaperone Cosmc in human leukocytes expressing tn antigen
@ast
Epigenetic silencing of the chaperone Cosmc in human leukocytes expressing tn antigen
@en
prefLabel
Epigenetic silencing of the chaperone Cosmc in human leukocytes expressing tn antigen
@ast
Epigenetic silencing of the chaperone Cosmc in human leukocytes expressing tn antigen
@en
P2093
P2860
P356
P1476
Epigenetic silencing of the chaperone Cosmc in human leukocytes expressing tn antigen
@en
P2093
Arlene B Chapman
Irma van Die
Jianmei Wang
Junwei Zeng
Rajindra P Aryal
Richard D Cummings
Rongjuan Mi
Sylvain Lehoux
Tongzhong Ju
P2860
P304
41523-41533
P356
10.1074/JBC.M112.371989
P407
P577
2012-10-03T00:00:00Z