Defective angiogenesis and fatal embryonic hemorrhage in mice lacking core 1-derived O-glycans.
about
Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in miceCo-translational function of Cosmc, core 1 synthase specific molecular chaperone, revealed by a cell-free translation systemEndothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in miceThrombocytopenia and kidney disease in mice with a mutation in the C1galt1 geneMucin-type O-glycosylation during developmentProfiles of human milk oligosaccharides and production of some human milk oligosaccharides in transgenic animalsIntegrity of Narrow Epithelial Tubes in the C. elegans Excretory System Requires a Transient Luminal MatrixCosmc is an essential chaperone for correct protein O-glycosylationAgm1/Pgm3-mediated sugar nucleotide synthesis is essential for hematopoiesis and developmentPremature ovarian failure in mice with oocytes lacking core 1-derived O-glycans and complex N-glycans.Glycobiology on the fly: developmental and mechanistic insights from DrosophilaGlycosyltransferase-specific Golgi-targeting mechanisms.The endoplasmic reticulum chaperone Cosmc directly promotes in vitro folding of T-synthase.Characterization and expression analysis of Galnts in developing Strongylocentrotus purpuratus embryos.C1GALT1 overexpression promotes the invasive behavior of colon cancer cells through modifying O-glycosylation of FGFR2.Structure and biological roles of mucin-type O-glycans at the ocular surface.An O-glycosyltransferase promotes cell adhesion during development by influencing secretion of an extracellular matrix integrin ligand.The role of mucin-type O-glycans in eukaryotic developmentCore2 O-glycan structure is essential for the cell surface expression of sucrase isomaltase and dipeptidyl peptidase-IV during intestinal cell differentiationMouse fertility is enhanced by oocyte-specific loss of core 1-derived O-glycans.Mucin-type O-glycosylation is critical for vascular integrity.Identification of distinct glycoforms of IgA1 in plasma from patients with immunoglobulin A (IgA) nephropathy and healthy individualsA novel fluorescent assay for T-synthase activity.Podoplanin requires sialylated O-glycans for stable expression on lymphatic endothelial cells and for interaction with platelets.Cytoplasmic domain of P-selectin glycoprotein ligand-1 facilitates dimerization and export from the endoplasmic reticulumEmerging paradigms for the initiation of mucin-type protein O-glycosylation by the polypeptide GalNAc transferase family of glycosyltransferases.Aberrant Cosmc genes result in Tn antigen expression in human colorectal carcinoma cell line HT-29.Lack of endothelial cell survivin causes embryonic defects in angiogenesis, cardiogenesis, and neural tube closure.Promoters of Human Cosmc and T-synthase Genes Are Similar in Structure, Yet Different in Epigenetic RegulationTight complex formation between Cosmc chaperone and its specific client non-native T-synthase leads to enzyme activity and client-driven dissociation.Complex N-glycans are essential, but core 1 and 2 mucin O-glycans, O-fucose glycans, and NOTCH1 are dispensable, for mammalian spermatogenesisIncreased susceptibility to colitis and colorectal tumors in mice lacking core 3-derived O-glycans.Regulation of Notch signaling by glycosylation.Embryos generated from oocytes lacking complex N- and O-glycans have compromised development and implantation.Epigenetic silencing of the chaperone Cosmc in human leukocytes expressing tn antigenRegulation of protein O-glycosylation by the endoplasmic reticulum-localized molecular chaperone Cosmc.A mucin-type O-glycosyltransferase modulates cell adhesion during Drosophila developmentThe lectin domain of the polypeptide GalNAc transferase family of glycosyltransferases (ppGalNAc Ts) acts as a switch directing glycopeptide substrate glycosylation in an N- or C-terminal direction, further controlling mucin type O-glycosylationGlycan antagonists and inhibitors: a fount for drug discovery.Recent insights into the biological roles of mucin-type O-glycosylation
P2860
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P2860
Defective angiogenesis and fatal embryonic hemorrhage in mice lacking core 1-derived O-glycans.
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Defective angiogenesis and fat ...... cking core 1-derived O-glycans
@nl
Defective angiogenesis and fat ...... king core 1-derived O-glycans.
@ast
Defective angiogenesis and fat ...... king core 1-derived O-glycans.
@en
type
label
Defective angiogenesis and fat ...... cking core 1-derived O-glycans
@nl
Defective angiogenesis and fat ...... king core 1-derived O-glycans.
@ast
Defective angiogenesis and fat ...... king core 1-derived O-glycans.
@en
prefLabel
Defective angiogenesis and fat ...... cking core 1-derived O-glycans
@nl
Defective angiogenesis and fat ...... king core 1-derived O-glycans.
@ast
Defective angiogenesis and fat ...... king core 1-derived O-glycans.
@en
P2093
P2860
P3181
P356
P1476
Defective angiogenesis and fat ...... king core 1-derived O-glycans.
@en
P2093
Andrew Westmuckett
Florea Lupu
Guangyu An
J Michael McDaniel
Lacramioara Ivanciu
Richard D Cummings
Rodger P McEver
Tongzhong Ju
P2860
P304
P3181
P356
10.1083/JCB.200311112
P407
P577
2004-01-26T00:00:00Z