Naturally occurring mutations at the acetylcholine receptor binding site independently alter ACh binding and channel gating.
about
End-plate acetylcholine receptor: structure, mechanism, pharmacology, and diseaseCongenital myasthenic syndromes: pathogenesis, diagnosis, and treatmentPrinciples of agonist recognition in Cys-loop receptorsHighly fatal fast-channel syndrome caused by AChR ε subunit mutation at the agonist binding siteRecent advances in Cys-loop receptor structure and functionUnresponsive correlated motion in alpha7 nAChR to halothane binding explains its functional insensitivity to volatile anesthetics.Mutation causing severe myasthenia reveals functional asymmetry of AChR signature cystine loops in agonist binding and gating.Insights into channel function via channel dysfunctionLife at the top: the transition state of AChR gating.Evidence for an extended hydrogen bond network in the binding site of the nicotinic receptor: role of the vicinal disulfide of the alpha1 subunit.Agonist-activated ion channels.Invariant aspartic Acid in muscle nicotinic receptor contributes selectively to the kinetics of agonist bindingInitial coupling of binding to gating mediated by conserved residues in the muscle nicotinic receptorFunctional characterization of neurotransmitter activation and modulation in a nematode model ligand-gated ion channel.Structural rearrangements in loop F of the GABA receptor signal ligand binding, not channel activation.Long-range coupling in an allosteric receptor revealed by mutant cycle analysisCrystal structure and dynamics of a lipid-induced potential desensitized-state of a pentameric ligand-gated channel.An outline of desensitization in pentameric ligand-gated ion channel receptors.The energetic consequences of loop 9 gating motions in acetylcholine receptor-channels.Properties of the human muscle nicotinic receptor, and of the slow-channel myasthenic syndrome mutant epsilonL221F, inferred from maximum likelihood fits.An intersubunit hydrogen bond in the nicotinic acetylcholine receptor that contributes to channel gating.The GABAA receptor alpha 1 subunit Pro174-Asp191 segment is involved in GABA binding and channel gating.Principal pathway coupling agonist binding to channel gating in nicotinic receptors.
P2860
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P2860
Naturally occurring mutations at the acetylcholine receptor binding site independently alter ACh binding and channel gating.
description
2002 nî lūn-bûn
@nan
2002年の論文
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2002年学术文章
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2002年学术文章
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2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
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2002年學術文章
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name
Naturally occurring mutations ...... Ch binding and channel gating.
@ast
Naturally occurring mutations ...... Ch binding and channel gating.
@en
type
label
Naturally occurring mutations ...... Ch binding and channel gating.
@ast
Naturally occurring mutations ...... Ch binding and channel gating.
@en
prefLabel
Naturally occurring mutations ...... Ch binding and channel gating.
@ast
Naturally occurring mutations ...... Ch binding and channel gating.
@en
P2093
P2860
P356
P1476
Naturally occurring mutations ...... ACh binding and channel gating
@en
P2093
Akira Tsujino
Andrew G Engel
Hai-Long Wang
Jiri Vajsar
Joan Brengmann
Steven M Sine
Won-Yong Lee
Xing-Ming Shen
P2860
P304
P356
10.1085/JGP.20028568
P50
P577
2002-10-01T00:00:00Z