Properties of the human muscle nicotinic receptor, and of the slow-channel myasthenic syndrome mutant epsilonL221F, inferred from maximum likelihood fits.
about
End-plate acetylcholine receptor: structure, mechanism, pharmacology, and diseaseActivation of single heteromeric GABA(A) receptor ion channels by full and partial agonistsRecent advances in Cys-loop receptor structure and functionGating of acetylcholine receptor channels: brownian motion across a broad transition state.Analysis of single ion channel data incorporating time-interval omission and sampling.The quality of maximum likelihood estimates of ion channel rate constants.How to impose microscopic reversibility in complex reaction mechanismsPotential new therapeutic modality revealed through agent-based modeling of the neuromuscular junction and acetylcholinesterase inhibitionStatistical evaluation of ion-channel gating models based on distributions of log-likelihood ratios.What have we learned from the congenital myasthenic syndromesDesign and control of acetylcholine receptor conformational changeOn the nature of partial agonism in the nicotinic receptor superfamily.Structure of the first transmembrane domain of the neuronal acetylcholine receptor beta2 subunitPhenotypic heterogeneity in a large Thai slow-channel congenital myasthenic syndrome kinship.The intrinsic energy of the gating isomerization of a neuromuscular acetylcholine receptor channel.Novel beta subunit mutation causes a slow-channel syndrome by enhancing activation and decreasing the rate of agonist dissociationEstimating binding affinities of the nicotinic receptor for low-efficacy ligands using mixtures of agonists and two-dimensional concentration-response relationshipsAgonist-activated ion channels.Invariant aspartic Acid in muscle nicotinic receptor contributes selectively to the kinetics of agonist bindingInitial coupling of binding to gating mediated by conserved residues in the muscle nicotinic receptorImproved resolution of single channel dwell times reveals mechanisms of binding, priming, and gating in muscle AChR.Decremental response to high-frequency trains of acetylcholine pulses but unaltered fractional Ca2+ currents in a panel of "slow-channel syndrome" nicotinic receptor mutants.What single-channel analysis tells us of the activation mechanism of ligand-gated channels: the case of the glycine receptor.Impaired NGF/TrkA Signaling Causes Early AD-Linked Presynaptic Dysfunction in Cholinergic Primary NeuronsBayesian Statistical Inference in Ion-Channel Models with Exact Missed Event Correction.Distinct activities of GABA agonists at synaptic- and extrasynaptic-type GABAA receptors.Agonist and blocking actions of choline and tetramethylammonium on human muscle acetylcholine receptors.Activation of recombinant NR1/NR2C NMDA receptors.Single-channel properties of glycine receptors of juvenile rat spinal motoneurones in vitro.Single-channel study of the spasmodic mutation alpha1A52S in recombinant rat glycine receptors.A human congenital myasthenia-causing mutation (epsilon L78P) of the muscle nicotinic acetylcholine receptor with unusual single channel properties.Mutations Causing Slow-Channel Myasthenia Reveal That a Valine Ring in the Channel Pore of Muscle AChR is Optimized for Stabilizing Channel Gating.From shut to open: what can we learn from linear free energy relationships?Perspectives on: conformational coupling in ion channels: allosteric coupling in ligand-gated ion channels.Recent structural and mechanistic insights into endplate acetylcholine receptors.Selective cleavage of AChR cRNAs harbouring mutations underlying the slow channel myasthenic syndrome by hammerhead ribozymes.Mechanistic contributions of residues in the M1 transmembrane domain of the nicotinic receptor to channel gating.Maximum likelihood fitting of single channel NMDA activity with a mechanism composed of independent dimers of subunits.Single-channel analysis of a point mutation of a conserved serine residue in the S2 ligand-binding domain of the NR2A NMDA receptor subunit.Gating dynamics of the acetylcholine receptor extracellular domain.
P2860
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P2860
Properties of the human muscle nicotinic receptor, and of the slow-channel myasthenic syndrome mutant epsilonL221F, inferred from maximum likelihood fits.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Properties of the human muscle ...... from maximum likelihood fits.
@en
type
label
Properties of the human muscle ...... from maximum likelihood fits.
@en
altLabel
Properties of the human muscle ...... d from maximum likelihood fits
@en
prefLabel
Properties of the human muscle ...... from maximum likelihood fits.
@en
P2093
P2860
P1476
Properties of the human muscle ...... from maximum likelihood fits.
@en
P2093
P2860
P304
P356
10.1113/JPHYSIOL.2002.034173
P407
P577
2003-01-24T00:00:00Z