Gating pore currents and the resting state of Nav1.4 voltage sensor domains
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Physiological and Pathophysiological Insights of Nav1.4 and Nav1.5 ComparisonOmega pore, an alternative ion channel permeation pathway involved in the development of several channelopathiesCharacterization of the honeybee AmNaV1 channel and tools to assess the toxicity of insecticidesProton currents constrain structural models of voltage sensor activation.Hydrophobic plug functions as a gate in voltage-gated proton channels.Cardiac Na Channels: Structure to FunctionFree-energy landscape of ion-channel voltage-sensor-domain activationGating pore currents are defects in common with two Nav1.5 mutations in patients with mixed arrhythmias and dilated cardiomyopathy.A cyclic nucleotide-gated channel mutation associated with canine daylight blindness provides insight into a role for the S2 segment tri-Asp motif in channel biogenesis.A recessive Nav1.4 mutation underlies congenital myasthenic syndrome with periodic paralysis.S1-S3 counter charges in the voltage sensor module of a mammalian sodium channel regulate fast inactivation.Computational tools to investigate genetic cardiac channelopathies.Molecular bases for the asynchronous activation of sodium and potassium channels required for nerve impulse generation.NaV1.4 mutations cause hypokalaemic periodic paralysis by disrupting IIIS4 movement during recovery.Biophysics, pathophysiology, and pharmacology of ion channel gating pores.Molecular biology and biophysical properties of ion channel gating pores.Voltage-gated proton (H(v)1) channels, a singular voltage sensing domain.Conservation of alternative splicing in sodium channels reveals evolutionary focus on release from inactivation and structural insights into gating.Nav 1.5 mutations linked to dilated cardiomyopathy phenotypes: Is the gating pore current the missing link?Voltage gating by molecular subunits of Na+ and K+ ion channels: higher-dimensional cubic kinetics, rate constants, and temperature.Gating pore currents, a new pathological mechanism underlying cardiac arrhythmias associated with dilated cardiomyopathy.Domain III S4 in closed-state fast inactivation: insights from a periodic paralysis mutationMutations in the Voltage Sensors of Domains I and II of Nav1.5 that are Associated with Arrhythmias and Dilated Cardiomyopathy Generate Gating Pore Currents.Mechanisms Responsible for ω-Pore Currents in Cav Calcium Channel Voltage-Sensing Domains.Structural and Functional Analysis of Sodium Channels Viewed from an Evolutionary Perspective.Substitutions of the S4DIV R2 residue (R1451) in NaV1.4 lead to complex forms of paramyotonia congenita and periodic paralyses.Stac3 enhances expression of human CaV1.1 in Xenopus oocytes and reveals gating pore currents in HypoPP mutant channels.Sodium Channelopathies of Skeletal Muscle.Voltage and pH sensing by the voltage-gated proton channel, HV1.A Mixed Periodic Paralysis & Myotonia Mutant, P1158S, Imparts pH-Sensitivity in Skeletal Muscle Voltage-gated Sodium Channels.Hypokalaemic periodic paralysis and myotonia in a patient with homozygous mutation p.R1451L in NaV1.4.A New Cardiac Channelopathy: From Clinical Phenotypes to Molecular Mechanisms Associated With Na1.5 Gating PoresA leaky voltage sensor domain of cardiac sodium channels causes arrhythmias associated with dilated cardiomyopathy
P2860
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P2860
Gating pore currents and the resting state of Nav1.4 voltage sensor domains
description
2012 nî lūn-bûn
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2012年の論文
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2012年学术文章
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2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
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2012年學術文章
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2012年學術文章
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name
Gating pore currents and the resting state of Nav1.4 voltage sensor domains
@ast
Gating pore currents and the resting state of Nav1.4 voltage sensor domains
@en
type
label
Gating pore currents and the resting state of Nav1.4 voltage sensor domains
@ast
Gating pore currents and the resting state of Nav1.4 voltage sensor domains
@en
prefLabel
Gating pore currents and the resting state of Nav1.4 voltage sensor domains
@ast
Gating pore currents and the resting state of Nav1.4 voltage sensor domains
@en
P2093
P2860
P356
P1476
Gating pore currents and the resting state of Nav1.4 voltage sensor domains
@en
P2093
Michael L Klein
Mohamed Chahine
Pascal Gosselin-Badaroudine
P2860
P304
19250-19255
P356
10.1073/PNAS.1217990109
P407
P577
2012-11-07T00:00:00Z