Genetic control of responses to Trypanosoma cruzi in mice: multiple genes influencing parasitemia and survival
about
Genes from Chagas susceptibility loci that are differentially expressed in T. cruzi-resistant mice are candidates accounting for impaired immunity.Coinfection with different Trypanosoma cruzi strains interferes with the host immune response to infection.Vaccination with trypomastigote surface antigen 1-encoding plasmid DNA confers protection against lethal Trypanosoma cruzi infection.Impaired innate immunity in Tlr4(-/-) mice but preserved CD8+ T cell responses against Trypanosoma cruzi in Tlr4-, Tlr2-, Tlr9- or Myd88-deficient mice.Involvement of CD4(+) Th1 cells in systemic immunity protective against primary and secondary challenges with Trypanosoma cruzi.Trypanosoma cruzi infection in genetically selected mouse lines: genetic linkage with quantitative trait locus controlling antibody response.During Trypanosoma cruzi infection CD1d-restricted NK T cells limit parasitemia and augment the antibody response to a glycophosphoinositol-modified surface proteinThe CC chemokine receptor 5 is important in control of parasite replication and acute cardiac inflammation following infection with Trypanosoma cruzi.The chemokines CXCL9 and CXCL10 promote a protective immune response but do not contribute to cardiac inflammation following infection with Trypanosoma cruzi.Major histocompatibility complex heterozygote superiority during coinfection.The use of a heterogeneously controlled mouse population reveals a significant correlation of acute phase parasitemia with mortality in Chagas disease.Pure paraflagellar rod protein protects mice against Trypanosoma cruzi infectionEvidence for a protective role of tumor necrosis factor in the acute phase of Trypanosoma cruzi infection in mice.IL-10 limits parasite burden and protects against fatal myocarditis in a mouse model of Trypanosoma cruzi infection.Pivotal role of interleukin-12 and interferon-gamma axis in controlling tissue parasitism and inflammation in the heart and central nervous system during Trypanosoma cruzi infection.The Immune Response to Trypanosoma cruzi: Role of Toll-Like Receptors and Perspectives for Vaccine Development.Interleukin 10 and interferon gamma regulation of experimental Trypanosoma cruzi infectionIdentification and synthesis of a major conserved antigenic epitope of Trypanosoma cruziSingle locus in BXH-2 mice responsible for inability to control early proliferation of Trypanosoma cruzi.Role of the H-2s haplotype in survival of mice after infection with Trypanosoma cruzi.Pathology affects different organs in two mouse strains chronically infected by a Trypanosoma cruzi clone: a model for genetic studies of Chagas' diseaseImmunodepression induced by Trypanosoma cruzi and mouse hepatitis virus type 3 is associated with thymus apoptosis.Bottlenecks in domestic animal populations can facilitate the emergence of Trypanosoma cruzi, the aetiological agent of Chagas disease.Differential susceptibility to acute Trypanosoma cruzi infection in BALB/c and C57BL/6 mice is not associated with a distinct parasite load but cytokine abnormalities
P2860
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P2860
Genetic control of responses to Trypanosoma cruzi in mice: multiple genes influencing parasitemia and survival
description
1982 nî lūn-bûn
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1982年の論文
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1982年学术文章
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1982年学术文章
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1982年学术文章
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1982年學術文章
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name
Genetic control of responses t ...... ncing parasitemia and survival
@ast
Genetic control of responses t ...... ncing parasitemia and survival
@en
type
label
Genetic control of responses t ...... ncing parasitemia and survival
@ast
Genetic control of responses t ...... ncing parasitemia and survival
@en
prefLabel
Genetic control of responses t ...... ncing parasitemia and survival
@ast
Genetic control of responses t ...... ncing parasitemia and survival
@en
P2093
P2860
P1476
Genetic control of responses t ...... ncing parasitemia and survival
@en
P2093
R Wrightsman
S Krassner
P2860
P304
P407
P577
1982-05-01T00:00:00Z