Ethanol selectively blocks a noninactivating K+ current expressed in Xenopus oocytes.
about
Simulation of alcohol action upon a detailed Purkinje neuron model and a simpler surrogate model that runs >400 times fasterGeneral anesthetic action at an internal protein site involving the S4-S5 cytoplasmic loop of a neuronal K(+) channelEthanol opens G-protein-activated inwardly rectifying K+ channelsKCNQ channels show conserved ethanol block and function in ethanol behaviour.Distinct molecular targets including SLO-1 and gap junctions are engaged across a continuum of ethanol concentrations in Caenorhabditis elegans.Inhalational anaesthetics and n-alcohols share a site of action in the neuronal Shaw2 Kv channel.Drosophila neuropeptide F and its receptor, NPFR1, define a signaling pathway that acutely modulates alcohol sensitivityMechanisms of anesthesia: towards integrating network, cellular, and molecular level modeling.Molecular mapping of general anesthetic sites in a voltage-gated ion channel.Mechanistic Insights into the Modulation of Voltage-Gated Ion Channels by Inhalational AnestheticsAlkanols inhibit voltage-gated K(+) channels via a distinct gating modifying mechanism that prevents gate opening.Molecular features of an alcohol binding site in a neuronal potassium channel.Novel activation of voltage-gated K(+) channels by sevoflurane.Excitation of rat cerebellar Golgi cells by ethanol: further characterization of the mechanism.The residue I257 at S4-S5 linker in KCNQ1 determines KCNQ1/KCNE1 channel sensitivity to 1-alkanolsHomeostatic control of neural activity: a Drosophila model for drug tolerance and dependenceEthanol's molecular targetsFatty acid ethyl esters, nonoxidative metabolites of ethanol, accelerate the kinetics of activation of the human brain delayed rectifier K+ channel, Kv1.1.Single-channel basis for conductance increase induced by isoflurane in Shaker H4 IR K(+) channels.Ethanol reduces excitability in a subgroup of primary sensory neurons by activation of BK(Ca) channels.Allosteric modulation of a neuronal K+ channel by 1-alkanols is linked to a key residue in the activation gate.Insight into the modulation of Shaw2 Kv channels by general anesthetics: structural and functional studies of S4-S5 linker and S6 C-terminal peptides in micelles by NMR.Alcohols inhibit a cloned potassium channel at a discrete saturable site. Insights into the molecular basis of general anesthesia.
P2860
Q21146708-CFACB49B-5F27-4CBB-B765-F0E1B8B7741FQ28370365-8535BBEF-7FD2-4796-8252-9452F599FFC9Q28376797-4D9E0E15-2827-4E79-9BC7-2579D4EDA0AFQ30460166-84DBC75B-06BB-41BC-8575-D71B0484E487Q30579957-2F9FF601-D2C9-424B-8873-A3426CB19E18Q33772880-E2907DA7-19C9-4789-96C1-552892DFF60FQ33836319-28EF16C6-ADE7-41C4-8B00-B29D0F6ABE59Q35162923-430F1364-B509-4556-84F6-69C4DC699FD3Q35246304-74DE44FA-73D4-4DF7-B38E-5EF19F5CF3AFQ36309696-6923F621-0C6D-497A-A045-91F36ECD9060Q36330508-5685DA9D-C035-4B3F-BC61-EDAF981FBD38Q36417172-C3C1989F-FD60-4E72-BC6A-C228B81D7965Q36418841-F0A84709-9A2A-45FB-8722-EFE1C8161A9DQ36474834-79DE1AA1-936B-4C66-8BA0-B4DF9EDC3D48Q36490541-12307BA7-D282-4639-AA52-171504E4F97EQ36887441-86A5BB5A-A743-4FDD-BB67-3B1CAA4156CFQ37165668-3C45C766-4CDF-4612-826B-E46155DDD9E9Q42063193-6DC4C6F5-59D3-45EA-9983-13D10860E7CCQ43565175-B5476278-CBB3-467D-801E-17857240CF1EQ43795831-7751AF68-E33A-4A53-A533-971485F26907Q44575118-63DFA301-B1DF-499A-BAEC-1F42104395C8Q48126441-FCCB58B5-DA9C-4408-B775-0CCCB07A5A88Q51596719-E351471D-D479-4F96-A447-E89AC77F51E3
P2860
Ethanol selectively blocks a noninactivating K+ current expressed in Xenopus oocytes.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年学术文章
@wuu
1993年学术文章
@zh-cn
1993年学术文章
@zh-hans
1993年学术文章
@zh-my
1993年学术文章
@zh-sg
1993年學術文章
@yue
1993年學術文章
@zh
1993年學術文章
@zh-hant
name
Ethanol selectively blocks a noninactivating K+ current expressed in Xenopus oocytes.
@ast
Ethanol selectively blocks a noninactivating K+ current expressed in Xenopus oocytes.
@en
type
label
Ethanol selectively blocks a noninactivating K+ current expressed in Xenopus oocytes.
@ast
Ethanol selectively blocks a noninactivating K+ current expressed in Xenopus oocytes.
@en
prefLabel
Ethanol selectively blocks a noninactivating K+ current expressed in Xenopus oocytes.
@ast
Ethanol selectively blocks a noninactivating K+ current expressed in Xenopus oocytes.
@en
P2860
P356
P1476
Ethanol selectively blocks a noninactivating K+ current expressed in Xenopus oocytes.
@en
P2093
Covarrubias M
P2860
P304
P356
10.1073/PNAS.90.15.6957
P407
P577
1993-08-01T00:00:00Z