Hammerhead ribozymes: importance of stem-loop II for activity.
about
Design and optimization of effector-activated ribozyme ligasesSecondary structure prediction and in vitro accessibility of mRNA as tools in the selection of target sites for ribozymesThe ubiquitous hammerhead ribozymeStructural diversity of self-cleaving ribozymesBis-aptazyme sensors for hepatitis C virus replicase and helicase without blank signal.Recent advances in the elucidation of the mechanisms of action of ribozymesFunctional nucleic acid sensorsHIV-1 LTR as a target for synthetic ribozyme-mediated inhibition of gene expression: site selection and inhibition in cell cultureHammerhead redux: does the new structure fit the old biochemical data?A further investigation and reappraisal of the thio effect in the cleavage reaction catalyzed by a hammerhead ribozyme.Engineered allosteric ribozymes that sense the bacterial second messenger cyclic diguanosyl 5'-monophosphate.Generating new ligand-binding RNAs by affinity maturation and disintegration of allosteric ribozymes.Synthetic hammerhead ribozymes as tools in gene expression.Characterization of several kinds of dimer minizyme: simultaneous cleavage at two sites in HIV-1 tat mRNA by dimer minizymes.Differences in the phosphate oxygen requirements for self-cleavage by the extended and prototypical hammerhead formsA small modified hammerhead ribozyme and its conformational characteristics determined by mutagenesis and lattice calculation.Kinetic characterization of intramolecular and intermolecular hammerhead RNAs with stem II deletions.In vitro selection of a purine nucleotide-specific hammerheadlike ribozyme.Development of lead hammerhead ribozyme candidates against human rod opsin mRNA for retinal degeneration therapy.Engineering precision RNA molecular switches.The newt ribozyme is part of a riboprotein complextRNAVal-heterodimeric maxizymes with high potential as geneinactivating agents: simultaneous cleavage at two sites in HIV-1 Tat mRNA in cultured cells.A multifunctional expression vector for an anti-HIV-1 ribozyme that produces a 5'- and 3'-trimmed trans-acting ribozyme, targeted against HIV-1 RNA, and cis-acting ribozymes that are designed to bind to and thereby sequester trans-activator proteinsThe roles of the conserved pyrimidine bases in hammerhead ribozyme catalysis: evidence for a magnesium ion-binding site.Divalent Metal Ion Activation of a Guanine General Base in the Hammerhead Ribozyme: Insights from Molecular Simulations.Unexpected anisotropy in substrate cleavage rates by asymmetric hammerhead ribozymes.In vitro selection of hammerhead ribozymes containing a bulged nucleotide in stem II.Allosteric regulation of a ribozyme activity through ligand-induced conformational change.Mechanism for allosteric inhibition of an ATP-sensitive ribozyme.Sequence specificity of the hammerhead ribozyme revisited; the NHH rule.Can hammerhead ribozymes be efficient tools to inactivate gene function?Comparative analysis of cleavage rates after systematic permutation of the NUX consensus target motif for hammerhead ribozymes.In vitro activity of minimised hammerhead ribozymesProbing the hammerhead ribozyme structure with ribonucleases.Extension of helix II of an HIV-1-directed hammerhead ribozyme with long antisense flanks does not alter kinetic parameters in vitro but causes loss of the inhibitory potential in living cells.Activity of hammerhead ribozymes containing non-nucleotidic linkers.The influence of imperfectly paired helices I and III on the catalytic activity of hammerhead ribozymes.Relationships between the activities in vitro and in vivo of various kinds of ribozyme and their intracellular localization in mammalian cells.Determination of 2'-hydroxyl and phosphate groups important for aminoacylation of Escherichia coli tRNAAsp: a nucleotide analogue interference study.An extra nucleotide in the consensus catalytic core of a viroid hammerhead ribozyme: implications for the design of more efficient ribozymes.
P2860
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P2860
Hammerhead ribozymes: importance of stem-loop II for activity.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年学术文章
@wuu
1993年学术文章
@zh-cn
1993年学术文章
@zh-hans
1993年学术文章
@zh-my
1993年学术文章
@zh-sg
1993年學術文章
@yue
1993年學術文章
@zh
1993年學術文章
@zh-hant
name
Hammerhead ribozymes: importance of stem-loop II for activity.
@ast
Hammerhead ribozymes: importance of stem-loop II for activity.
@en
type
label
Hammerhead ribozymes: importance of stem-loop II for activity.
@ast
Hammerhead ribozymes: importance of stem-loop II for activity.
@en
prefLabel
Hammerhead ribozymes: importance of stem-loop II for activity.
@ast
Hammerhead ribozymes: importance of stem-loop II for activity.
@en
P2860
P356
P1476
Hammerhead ribozymes: importance of stem-loop II for activity.
@en
P2093
Eckstein F
P2860
P304
P356
10.1073/PNAS.90.15.6991
P407
P577
1993-08-01T00:00:00Z