An emerging consensus on voltage-dependent gating from computational modeling and molecular dynamics simulations - Wikidata - awgldk - TriplyDB

An emerging consensus on voltage-dependent gating from computational modeling and molecular dynamics simulations

An emerging consensus on voltage-dependent gating from computational modeling and molecular dynamics simulations

http://www.wikidata.org/entity/Q36446413

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Theoretical and simulation studies on voltage-gated sodium channels Na+ channel function, regulation, structure, trafficking and sequestration Structural Refinement of Proteins by Restrained Molecular Dynamics Simulations with Non-interacting Molecular Fragments.Deciphering voltage-gated Na(+) and Ca(2+) channels by studying prokaryotic ancestors Structural Basis for Pharmacology of Voltage-Gated Sodium and Calcium Channels Structure and function of voltage-gated sodium channels at atomic resolution.Proton currents constrain structural models of voltage sensor activation.Regulation of KCNQ/Kv7 family voltage-gated K+ channels by lipids.Gating of Connexin Channels by transjunctional-voltage: Conformations and models of open and closed states.Hydrophobic plug functions as a gate in voltage-gated proton channels.Resin-acid derivatives as potent electrostatic openers of voltage-gated K channels and suppressors of neuronal excitability Moving gating charges through the gating pore in a Kv channel voltage sensor.Domain and interdomain energetics underlying gating in Shaker-type Kv channels Capturing distinct KCNQ2 channel resting states by metal ion bridges in the voltage-sensor domain.Electric fingerprint of voltage sensor domains.Voltage regulation of connexin channel conductance.Bacterial voltage-gated sodium channels (BacNa(V)s) from the soil, sea, and salt lakes enlighten molecular mechanisms of electrical signaling and pharmacology in the brain and heart.PIP₂-dependent coupling is prominent in Kv7.1 due to weakened interactions between S4-S5 and S6.Free-energy landscape of ion-channel voltage-sensor-domain activation Gating pore currents are defects in common with two Nav1.5 mutations in patients with mixed arrhythmias and dilated cardiomyopathy.Caution is required in interpretation of mutations in the voltage sensing domain of voltage gated channels as evidence for gating mechanisms Inter-subunit interactions across the upper voltage sensing-pore domain interface contribute to the concerted pore opening transition of Kv channels.Variational cross-validation of slow dynamical modes in molecular kinetics.A combined coarse-grained and all-atom simulation of TRPV1 channel gating and heat activation Voltage Sensing in Membranes: From Macroscopic Currents to Molecular Motions Unfolding of a Temperature-Sensitive Domain Controls Voltage-Gated Channel Activation.The Cole-Moore Effect: Still Unexplained?Intermediate state trapping of a voltage sensor Unraveling the strokes of ion channel molecular machines in computers.Retigabine holds KV7 channels open and stabilizes the resting potential.Fine-tuning of voltage sensitivity of the Kv1.2 potassium channel by interhelix loop dynamics S1-S3 counter charges in the voltage sensor module of a mammalian sodium channel regulate fast inactivation.Reciprocal voltage sensor-to-pore coupling leads to potassium channel C-type inactivation.Functional diversity of potassium channel voltage-sensing domains.Using molecular dynamics to elucidate the structural basis for function in pLGICs The isolated voltage sensing domain of the Shaker potassium channel forms a voltage-gated cation channel.Conduits of life's spark: a perspective on ion channel research since the birth of neuron.Fluorine-19 NMR and computational quantification of isoflurane binding to the voltage-gated sodium channel NaChBac.Mutations in the S6 gate isolate a late step in the activation pathway and reduce 4-AP sensitivity in shaker K(v) channel.Coarse-grained simulations of the gating current in the voltage-activated Kv1.2 channel.

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An emerging consensus on voltage-dependent gating from computational modeling and molecular dynamics simulations

http://www.wikidata.org/entity/Q36446413

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2012 nî lūn-bûn

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2012年学术文章

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2012年学术文章

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2012年學術文章

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2012年學術文章

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An emerging consensus on volta ...... molecular dynamics simulations

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An emerging consensus on volta ...... molecular dynamics simulations

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An emerging consensus on volta ...... molecular dynamics simulations

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The Journal of General Physiology

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An emerging consensus on volta ...... molecular dynamics simulations

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Benoît Roux

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Eduardo Perozo

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Ernesto Vargas

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Fatemeh Khalili-Araghi

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Francisco Bezanilla

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Michael L Klein

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Mounir Tarek

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William A Catterall

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P2860

Principles of conduction and hydrophobic gating in K+ channels

Determination of solution structures of proteins up to 40 kDa using CS-Rosetta with sparse NMR data from deuterated samples

Activation of Shaker potassium channels. III. An activation gating model for wild-type and V2 mutant channels

Normal-Mode Refinement of Anisotropic Thermal Parameters for Potassium Channel KcsA at 3.2 Å Crystallographic Resolution

Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment

Structure of the transmembrane regions of a bacterial cyclic nucleotide-regulated channel

The crystal structure of a voltage-gated sodium channel

Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel.

Crystal structure of a voltage-gated sodium channel in two potentially inactivated states

Improving the Accuracy of Macromolecular Structure Refinement at 7 Å Resolution

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587-594

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scholarly article

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10.1085/JGP.201210873

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6

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140

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Vladimir Yarov-Yarovoy

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2012-12-01T00:00:00Z

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23183694

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3514734

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