about
The bipolar assembly domain of the mitotic motor kinesin-5Na+ channel function, regulation, structure, trafficking and sequestrationA pain-inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1.Multipass membrane protein structure prediction using RosettaSequential formation of ion pairs during activation of a sodium channel voltage sensorCalculation of the gating charge for the Kv1.2 voltage-activated potassium channelVoltage-gated ion channels and gating modifier toxins.Overview of molecular relationships in the voltage-gated ion channel superfamily.Chemoselective tarantula toxins report voltage activation of wild-type ion channels in live cellsLocal anesthetic and antiepileptic drug access and binding to a bacterial voltage-gated sodium channelStructure and function of the voltage sensor of sodium channels probed by a beta-scorpion toxin.Finding homes for orphan cytochrome P450s: CYP4V2 and CYP4F22 in disease states.Identification of amino acid determinants in CYP4B1 for optimal catalytic processing of 4-ipomeanol.Structure-function map of the receptor site for β-scorpion toxins in domain II of voltage-gated sodium channelsAllosteric catch bond properties of the FimH adhesin from Salmonella enterica serovar Typhimurium.Tarantula toxins use common surfaces for interacting with Kv and ASIC ion channels.Constitutive coupling of a naturally occurring human alpha1a-adrenergic receptor genetic variant to EGFR transactivation pathwayStructural basis for gating charge movement in the voltage sensor of a sodium channelStructural mechanism underlying capsaicin binding and activation of the TRPV1 ion channel.Characterization of an Additional Splice Acceptor Site Introduced into CYP4B1 in Hominoidae during Evolution.Selective disruption of high sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations.A Large and Phylogenetically Diverse Class of Type 1 Opsins Lacking a Canonical Retinal Binding SiteMapping the interaction site for a β-scorpion toxin in the pore module of domain III of voltage-gated Na(+) channelsStructural Insights into the Atomistic Mechanisms of Action of Small Molecule Inhibitors Targeting the KCa3.1 Channel Pore.An emerging consensus on voltage-dependent gating from computational modeling and molecular dynamics simulationsNa⁺/K⁺-ATPase E960 and phospholemman F28 are critical for their functional interactionLG2 agrin mutation causing severe congenital myasthenic syndrome mimics functional characteristics of non-neural (z-) agrin.Disulfide locking a sodium channel voltage sensor reveals ion pair formation during activation.Rational design and validation of a vanilloid-sensitive TRPV2 ion channelActivity-Dependent Palmitoylation Controls SynDIG1 Stability, Localization, and Function.A novel tarantula toxin stabilizes the deactivated voltage sensor of bacterial sodium channel.A Polybasic Plasma Membrane Binding Motif in the I-II Linker Stabilizes Voltage-gated CaV1.2 Calcium Channel Function.Gain-of-function mutation of a voltage-gated sodium channel NaV1.7 associated with peripheral pain and impaired limb development.Molecular Interactions in the Voltage Sensor Controlling Gating Properties of CaV Calcium Channels.Computational Models for Predictive Cardiac Ion Channel Pharmacology.Autoinhibitory control of the CaV1.2 channel by its proteolytically processed distal C-terminal domain.In vivo optophysiology reveals that G-protein activation triggers osmotic swelling and increased light scattering of rod photoreceptors.Structural refinement of the hERG1 pore and voltage-sensing domains with ROSETTA-membrane and molecular dynamics simulations.Closing in on the resting state of the Shaker K(+) channel.Molecular determinants of voltage-dependent gating and binding of pore-blocking drugs in transmembrane segment IIIS6 of the Na(+) channel alpha subunit.
P50
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P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Vladimir Yarov-Yarovoy
@ast
Vladimir Yarov-Yarovoy
@en
Vladimir Yarov-Yarovoy
@es
Vladimir Yarov-Yarovoy
@nl
type
label
Vladimir Yarov-Yarovoy
@ast
Vladimir Yarov-Yarovoy
@en
Vladimir Yarov-Yarovoy
@es
Vladimir Yarov-Yarovoy
@nl
prefLabel
Vladimir Yarov-Yarovoy
@ast
Vladimir Yarov-Yarovoy
@en
Vladimir Yarov-Yarovoy
@es
Vladimir Yarov-Yarovoy
@nl
P106
P31
P496
0000-0002-2325-4834