Morphogenetic movements at gastrulation require the SH2 tyrosine phosphatase Shp2.
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Critical role for the docking-protein FRS2 alpha in FGF receptor-mediated signal transduction pathwaysQuantitative phosphotyrosine proteomics of EphB2 signaling by stable isotope labeling with amino acids in cell culture (SILAC)Essential role of Gab1 for signaling by the c-Met receptor in vivoHematopoietic specification from human pluripotent stem cells: current advances and challenges toward de novo generation of hematopoietic stem cells.Novel Mode of Defective Neural Tube Closure in the Non-Obese Diabetic (NOD) Mouse StrainShp2 knockdown and Noonan/LEOPARD mutant Shp2-induced gastrulation defectsThe bHLH regulator pMesogenin1 is required for maturation and segmentation of paraxial mesodermSHPS-1 regulates integrin-mediated cytoskeletal reorganization and cell motilityCoupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responsesPhosphoproteomics-mediated identification of Fer kinase as a target of mutant Shp2 in Noonan and LEOPARD syndromeActivated mutants of SHP-2 preferentially induce elongation of Xenopus animal capsPZR coordinates Shp2 Noonan and LEOPARD syndrome signaling in zebrafish and mice.The role of FGF and VEGF in angioblast induction and migration during vascular development.The Q510E mutation in Shp2 perturbs heart valve development by increasing cell migration.Xenopus: An emerging model for studying congenital heart disease.SHP-2 acts via ROCK to regulate the cardiac actin cytoskeleton.Essential function of PTP-PEST during mouse embryonic vascularization, mesenchyme formation, neurogenesis and early liver development.Shp2 plays a crucial role in cell structural orientation and force polarity in response to matrix rigidityNon-canonical Wnt signaling through Wnt5a/b and a novel Wnt11 gene, Wnt11b, regulates cell migration during avian gastrulation.Downstream-of-FGFR is a fibroblast growth factor-specific scaffolding protein and recruits Corkscrew upon receptor activation.Spina Bifida: Pathogenesis, Mechanisms, and Genes in Mice and HumansSHP-2 deletion in postmigratory neural crest cells results in impaired cardiac sympathetic innervation.Regulation of endothelial cell differentiation and specificationTraffic jam in the primitive streak: the role of defective mesoderm migration in birth defects.DNA methyltransferase inhibition induces mouse embryonic stem cell differentiation into endothelial cells.Macrophage-Restricted Shp2 Tyrosine Phosphatase Acts as a Rheostat for MMP12 through TGF-β Activation in the Prevention of Age-Related Emphysema in Mice.Resistance of B16 melanoma cells to CD47-induced negative regulation of motility as a result of aberrant N-glycosylation of SHPS-1.Regulation of CXCR4-mediated chemotaxis and chemoinvasion of breast cancer cells.Slit protein-mediated inhibition of CXCR4-induced chemotactic and chemoinvasive signaling pathways in breast cancer cells.Concerted functions of Gab1 and Shp2 in liver regeneration and hepatoprotectionShp-2 mediates v-Src-induced morphological changes and activation of the anti-apoptotic protein kinase Akt.Shp2 acts downstream of SDF-1alpha/CXCR4 in guiding granule cell migration during cerebellar development.Regulation of interleukin-3-induced substrate phosphorylation and cell survival by SHP-2 (Src-homology protein tyrosine phosphatase 2).Adrenocorticotrophic hormone stimulates phosphotyrosine phosphatase SHP2 in bovine adrenocortical cells: phosphorylation and activation by cAMP-dependent protein kinase.Embryonic vasculogenesis and hematopoietic specification.Netrin stimulates tyrosine phosphorylation of the UNC-5 family of netrin receptors and induces Shp2 binding to the RCM cytodomain.SHP2-Mediated Signal Networks in Stem Cell Homeostasis and Dysfunction.
P2860
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P2860
Morphogenetic movements at gastrulation require the SH2 tyrosine phosphatase Shp2.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
Morphogenetic movements at gastrulation require the SH2 tyrosine phosphatase Shp2.
@ast
Morphogenetic movements at gastrulation require the SH2 tyrosine phosphatase Shp2.
@en
type
label
Morphogenetic movements at gastrulation require the SH2 tyrosine phosphatase Shp2.
@ast
Morphogenetic movements at gastrulation require the SH2 tyrosine phosphatase Shp2.
@en
prefLabel
Morphogenetic movements at gastrulation require the SH2 tyrosine phosphatase Shp2.
@ast
Morphogenetic movements at gastrulation require the SH2 tyrosine phosphatase Shp2.
@en
P2860
P356
P1476
Morphogenetic movements at gastrulation require the SH2 tyrosine phosphatase Shp2.
@en
P2093
P2860
P304
P356
10.1073/PNAS.96.7.3790
P407
P577
1999-03-01T00:00:00Z