Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses
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Ligand-regulated binding of FAP68 to the hepatocyte growth factor receptorMUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of metRoles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factorDistinct domains in the SHP-2 phosphatase differentially regulate epidermal growth factor receptor/NF-kappaB activation through Gab1 in glioblastoma cellsSH3 domains of Grb2 adaptor bind to PXpsiPXR motifs within the Sos1 nucleotide exchange factor in a discriminate mannerBivalent binding drives the formation of the Grb2-Gab1 signaling complex in a noncooperative mannerA novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activationIdentification of Fer tyrosine kinase localized on microtubules as a platelet endothelial cell adhesion molecule-1 phosphorylating kinase in vascular endothelial cellsInvolvement of Lgl and Mahjong/VprBP in cell competitionPrinciples of interleukin (IL)-6-type cytokine signalling and its regulationPKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2.Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functionsThe discovery of hepatocyte growth factor (HGF) and its significance for cell biology, life sciences and clinical medicineStimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteinsGrb2-associated binding (Gab) proteins in hematopoietic and immune cell biologyAn overview of the c-MET signaling pathwayThe neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cellsNovel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiationEssential role of Gab1 for signaling by the c-Met receptor in vivoDysregulation of the Met pathway in non-small cell lung cancer: implications for drug targeting and resistanceMET: a critical player in tumorigenesis and therapeutic targetSubversion of Cell Signaling Pathways by Hepatitis C Virus Nonstructural 5A Protein via Interaction with Grb2 and P85 Phosphatidylinositol 3-KinaseMolecular Basis of Gain-of-Function LEOPARD Syndrome-Associated SHP2 MutationsBiology of MET: a double life between normal tissue repair and tumor progressionA deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKPGC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2The role of Gab family scaffolding adapter proteins in the signal transduction of cytokine and growth factor receptorsHGF/SF-met signaling in the control of branching morphogenesis and invasionInteraction domains: from simple binding events to complex cellular behaviorFibroblast growth factor signaling in Caenorhabditis elegansProtein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factorGab1 phosphorylation: a novel mechanism for negative regulation of HGF receptor signalingThe C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motifUCS15A, a novel small molecule, SH3 domain-mediated protein-protein interaction blocking drugShcB and ShcC activation by the Trk family of receptor tyrosine kinasesPak4, a novel Gab1 binding partner, modulates cell migration and invasion by the Met receptorB-cell receptor signalling and its crosstalk with other pathways in normal and malignant cellsOrder and disorder in large multi-site docking proteins of the Gab family--implications for signalling complex formation and inhibitor design strategiesRAI(ShcC/N-Shc)-dependent recruitment of GAB 1 to RET oncoproteins potentiates PI 3-K signalling in thyroid tumorsRegulation of c-Met-dependent gene expression by PTEN
P2860
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P2860
Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses
description
2000 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հունիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2000
@ast
im Juni 2000 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2000/06/26)
@sk
vědecký článek publikovaný v roce 2000
@cs
wetenschappelijk artikel (gepubliceerd op 2000/06/26)
@nl
наукова стаття, опублікована в червні 2000
@uk
مقالة علمية (نشرت في 26-6-2000)
@ar
name
Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses
@ast
Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses
@en
Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses
@nl
type
label
Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses
@ast
Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses
@en
Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses
@nl
prefLabel
Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses
@ast
Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses
@en
Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses
@nl
P2093
P2860
P356
P1476
Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses
@en
P2093
B. Kempkes
K. P. Fuchs
N. H. Gehring
U. Schaeper
W. Birchmeier
P2860
P304
P356
10.1083/JCB.149.7.1419
P407
P577
2000-06-26T00:00:00Z