How does activation loop phosphorylation modulate catalytic activity in the cAMP-dependent protein kinase: a theoretical study.
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Phosphorylation of the Arp2 subunit relieves auto-inhibitory interactions for Arp2/3 complex activationComputational delineation of tyrosyl-substrate recognition and catalytic landscapes by the epidermal growth factor receptor tyrosine kinase domain.Structural dynamic analysis of apo and ATP-bound IRAK4 kinaseAllosteric regulation of glycogen synthase kinase 3β: a theoretical study.Quantum mechanics/molecular mechanics investigation of the mechanism of phosphate transfer in human uridine-cytidine kinase 2.Dynamic switching mechanisms in LOV1 and LOV2 domains of plant phototropins.Dynamic Allostery Mediated by a Conserved Tryptophan in the Tec Family Kinases.Reaction Pathway and Free Energy Profile for Cocaine Hydrolase-Catalyzed Hydrolysis of (-)-CocaineFree energies of chemical reactions in solution and in enzymes with ab initio quantum mechanics/molecular mechanics methodsFundamental reaction mechanism and free energy profile for (-)-cocaine hydrolysis catalyzed by cocaine esteraseDesign-atom approach for the quantum mechanical/molecular mechanical covalent boundary: a design-carbon atom with five valence electrons.Recent advances in methods to assess the activity of the kinome.Why does the G117H mutation considerably improve the activity of human butyrylcholinesterase against sarin? Insights from quantum mechanical/molecular mechanical free energy calculations.A QM/MM study of Kemptide phosphorylation catalyzed by protein kinase A. The role of Asp166 as a general acid/base catalyst.Reaction pathway and free-energy barrier for reactivation of dimethylphosphoryl-inhibited human acetylcholinesterasePIK3CA somatic mutations in breast cancer: Mechanistic insights from Langevin dynamics simulations.Reaction mechanism for cocaine esterase-catalyzed hydrolyses of (+)- and (-)-cocaine: unexpected common rate-determining step.Highly dissociative and concerted mechanism for the nicotinamide cleavage reaction in Sir2Tm enzyme suggested by ab initio QM/MM molecular dynamics simulations.Theoretical studies of cyclic adenosine monophosphate dependent protein kinase: native enzyme and ground-state and transition-state analogues.In silico evaluation of the resistance of the T790M variant of epidermal growth factor receptor kinase to cancer drug Erlotinib.A QM/MM study of the associative mechanism for the phosphorylation reaction catalyzed by protein kinase A and its D166A mutant.A QM/MM study of the phosphoryl transfer to the Kemptide substrate catalyzed by protein kinase A. The effect of the phosphorylation state of the protein on the mechanism.QM/MM-Methoden für biomolekulare Systeme
P2860
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P2860
How does activation loop phosphorylation modulate catalytic activity in the cAMP-dependent protein kinase: a theoretical study.
description
2006 nî lūn-bûn
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2006年の論文
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2006年学术文章
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name
How does activation loop phosp ...... n kinase: a theoretical study.
@ast
How does activation loop phosp ...... n kinase: a theoretical study.
@en
type
label
How does activation loop phosp ...... n kinase: a theoretical study.
@ast
How does activation loop phosp ...... n kinase: a theoretical study.
@en
prefLabel
How does activation loop phosp ...... n kinase: a theoretical study.
@ast
How does activation loop phosp ...... n kinase: a theoretical study.
@en
P2860
P356
P1433
P1476
How does activation loop phosp ...... n kinase: a theoretical study.
@en
P2093
Yingkai Zhang
Yuhui Cheng
P2860
P304
P356
10.1110/PS.051852306
P577
2006-03-07T00:00:00Z