Functional evolution of the p53 regulatory network through its target response elements.
about
Foxa1 functions as a pioneer transcription factor at transposable elements to activate Afp during differentiation of embryonic stem cellsStructure of p73 DNA-binding domain tetramer modulates p73 transactivationTransactivation specificity is conserved among p53 family proteins and depends on a response element sequence codeThe coordinated p53 and estrogen receptor cis-regulation at an FLT1 promoter SNP is specific to genotoxic stress and estrogenic compoundp53 transactivation and the impact of mutations, cofactors and small molecules using a simplified yeast-based screening systemQuantitative Analysis of NF-κB Transactivation Specificity Using a Yeast-Based Functional AssayEstrogen receptor acting in cis enhances WT and mutant p53 transactivation at canonical and noncanonical p53 target sequences.Two p53 tetramers bind one consensus DNA response elementNoncanonical DNA motifs as transactivation targets by wild type and mutant p53Regression based predictor for p53 transactivation.Conservation of DNA-binding specificity and oligomerisation properties within the p53 family.∆N-P63α and TA-P63α exhibit intrinsic differences in transactivation specificities that depend on distinct features of DNA target sites.The Toll-like receptor gene family is integrated into human DNA damage and p53 networks.P53 family members modulate the expression of PRODH, but not PRODH2, via intronic p53 response elements.Characterization of the p53 cistrome--DNA binding cooperativity dissects p53's tumor suppressor functions.Identification of new p53 target microRNAs by bioinformatics and functional analysisEvolution of p53 transactivation specificity through the lens of a yeast-based functional assayWhole-genome cartography of p53 response elements ranked on transactivation potential.Functional analyses of human DNA repair proteins important for aging and genomic stability using yeast geneticsThe human TLR innate immune gene family is differentially influenced by DNA stress and p53 status in cancer cells.It Takes 15 to Tango: Making Sense of the Many Ubiquitin Ligases of p53.Probing the functional impact of sequence variation on p53-DNA interactions using a novel microsphere assay for protein-DNA binding with human cell extractsRecent advances in p53 research: an interdisciplinary perspective.A regulatory loop composed of RAP80-HDM2-p53 provides RAP80-enhanced p53 degradation by HDM2 in response to DNA damage.Codon 104 variation of p53 gene provides adaptive apoptotic responses to extreme environments in mammals of the Tibet plateau.Rotational positioning of nucleosomes facilitates selective binding of p53 to response elements associated with cell cycle arrest.Human transcription factors in yeast: the fruitful examples of P53 and NF-кB.Gene entropy-fractal dimension informatics with application to mouse-human translational medicine.TLR2∆22 (-196-174) significantly increases the risk of breast cancer in females carrying proline allele at codon 72 of TP53 gene: a case-control study from four ethnic groups of North Eastern region of India.Identification of p53-target genes in Danio rerioComparative epigenomic annotation of regulatory DNA.Evolution of the mammalian transcription factor binding repertoire via transposable elements.P53 binding sites in transposons.The transcriptional response of mammalian cancer cells to irradiation is dominated by a cell cycle signature which is strongly attenuated in non-cancer cells and tissues.TP53 Regulates Transcription of DNA Repair GenesConservation and Divergence of p53 Oscillation Dynamics across Species.A highly specific SpCas9 variant is identified by in vivo screening in yeast.
P2860
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P2860
Functional evolution of the p53 regulatory network through its target response elements.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Functional evolution of the p53 regulatory network through its target response elements.
@ast
Functional evolution of the p53 regulatory network through its target response elements.
@en
type
label
Functional evolution of the p53 regulatory network through its target response elements.
@ast
Functional evolution of the p53 regulatory network through its target response elements.
@en
prefLabel
Functional evolution of the p53 regulatory network through its target response elements.
@ast
Functional evolution of the p53 regulatory network through its target response elements.
@en
P2093
P2860
P356
P1476
Functional evolution of the p53 regulatory network through its target response elements.
@en
P2093
Alberto Inga
Daniel Menendez
Michael A Resnick
P2860
P304
P356
10.1073/PNAS.0704694105
P407
P577
2008-01-10T00:00:00Z