Negative epistasis between the malaria-protective effects of alpha+-thalassemia and the sickle cell trait. - Wikidata - awgldk - TriplyDB

Negative epistasis between the malaria-protective effects of alpha+-thalassemia and the sickle cell trait.

Negative epistasis between the malaria-protective effects of alpha+-thalassemia and the sickle cell trait.

http://www.wikidata.org/entity/Q36463313

about

Population genetics of malaria resistance in humans Resistance to malaria in humans: the impact of strong, recent selection The effect of alpha+-thalassaemia on the incidence of malaria and other diseases in children living on the coast of Kenya The distribution of haemoglobin C and its prevalence in newborns in Africa Global distribution of the sickle cell gene and geographical confirmation of the malaria hypothesis Impaired cytoadherence of Plasmodium falciparum-infected erythrocytes containing sickle hemoglobin Heritability of malaria in Africa Genetic polymorphisms linked to susceptibility to malaria Negative health implications of sickle cell trait in high income countries: from the football field to the laboratory Abnormal PfEMP1/knob display on Plasmodium falciparum-infected erythrocytes containing hemoglobin variants: fresh insights into malaria pathogenesis and protection The inherited diseases of hemoglobin are an emerging global health burden.Reappraisal of known malaria resistance loci in a large multicenter study Global genetic architecture of an erythroid quantitative trait locus, HMIP-2 Profile: The Kilifi Health and Demographic Surveillance System (KHDSS)Molecular adaptation of modern human populations African genetic diversity: implications for human demographic history, modern human origins, and complex disease mapping Tackling the malaria problem in the South-East Asia Region: need for a change in policy?On the performance of multiple imputation based on chained equations in tackling missing data of the African α3.7 -globin deletion in a malaria association study Glucose-6-phosphate dehydrogenase deficiency and the risk of malaria and other diseases in children in Kenya: a case-control and a cohort study.Heterozygote advantage for fecundity.Increased microerythrocyte count in homozygous alpha(+)-thalassaemia contributes to protection against severe malarial anaemia Evolution of virulence in malaria A novel functional variant in the stem cell growth factor promoter protects against severe malarial anemia Nutritional status of young children with inherited blood disorders in western Kenya.Stimulated innate resistance of lung epithelium protects mice broadly against bacteria and fungi.Genome wide linkage study, using a 250K SNP map, of Plasmodium falciparum infection and mild malaria attack in a Senegalese population.Heterozygous HbAC but not HbAS is associated with higher newborn birthweight among women with pregnancy-associated malaria.Malaria in patients with sickle cell anemia: burden, risk factors, and outcome at the outpatient clinic and during hospitalization.Sickle Cell Disease in the Post Genomic Era: A Monogenic Disease with a Polygenic Phenotype.The co-inheritance of alpha-thalassemia and sickle cell anemia is associated with better hematological indices and lower consultations rate in Cameroonian patients and could improve their survival.Malaria parasites and red cell variants: when a house is not a home.A novel evolution-based method for detecting gene-gene interactions.Haptoglobin, alpha-thalassaemia and glucose-6-phosphate dehydrogenase polymorphisms and risk of abnormal transcranial Doppler among patients with sickle cell anaemia in Tanzania.Missing heritability of common diseases and treatments outside the protein-coding exome.α-Thalassemia impairs the cytoadherence of Plasmodium falciparum-infected erythrocytes The ratio of monocytes to lymphocytes in peripheral blood correlates with increased susceptibility to clinical malaria in Kenyan children Associations between red cell polymorphisms and Plasmodium falciparum infection in the middle belt of Ghana An assessment of the impact of host polymorphisms on Plasmodium falciparum var gene expression patterns among Kenyan children Disentangling genetic variation for resistance and tolerance to infectious diseases in animals.Iron metabolism and malaria.

P2860

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P2860

Negative epistasis between the malaria-protective effects of alpha+-thalassemia and the sickle cell trait.

http://www.wikidata.org/entity/Q36463313

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2005 nî lūn-bûn

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Nature Genetics

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Alex Macharia

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David J Weatherall

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Jedidah K Mwacharo

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Sammy Wambua

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Sophie Uyoga

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P2860

Sickle cell trait and the risk of Plasmodium falciparum malaria and other childhood diseases

Protection against malaria morbidity: near-fixation of the alpha-thalassemia gene in a Nepalese population

Protective effects of the sickle cell gene against malaria morbidity and mortality

The population genetics of the haemoglobinopathies.

Enhanced phagocytosis of ring-parasitized mutant erythrocytes: a common mechanism that may explain protection against falciparum malaria in sickle trait and beta-thalassemia trait.

POLYMORPHISM AND NATURAL SELECTION IN HUMAN POPULATIONS.

Natural selection of hemi- and heterozygotes for G6PD deficiency in Africa by resistance to severe malaria.

A human complement receptor 1 polymorphism that reduces Plasmodium falciparum rosetting confers protection against severe malaria.

The hydration state of human red blood cells and their susceptibility to invasion by Plasmodium falciparum

Identification of novel susceptibility loci for inflammatory bowel disease on chromosomes 1p, 3q, and 4q: evidence for epistasis between 1p and IBD1.

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1253-1257

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10.1038/NG1660

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11

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37

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Bridget S Penman

Thomas N Williams

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2005-10-16T00:00:00Z

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7538390

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