Improving metabolic stability by glycosylation: bifunctional peptide derivatives that are opioid receptor agonists and neurokinin 1 receptor antagonists
about
Investigational peptide and peptidomimetic μ and δ opioid receptor agonists in the relief of painTransporters at CNS barrier sites: obstacles or opportunities for drug delivery?Glycosylation, an effective synthetic strategy to improve the bioavailability of therapeutic peptides.Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligandsBiological and conformational evaluation of bifunctional compounds for opioid receptor agonists and neurokinin 1 receptor antagonists possessing two penicillaminesDiscovery of a potent and efficacious peptide derivative for δ/μ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies.Discovery of tripeptide-derived multifunctional ligands possessing delta/mu opioid receptor agonist and neurokinin 1 receptor antagonist activities.Truncation of the peptide sequence in bifunctional ligands with mu and delta opioid receptor agonist and neurokinin 1 receptor antagonist activitiesDesign of peptide and peptidomimetic ligands with novel pharmacological activity profiles.The biological activity and metabolic stability of peptidic bifunctional compounds that are opioid receptor agonists and neurokinin-1 receptor antagonists with a cystine moiety.Effect of anchoring 4-anilidopiperidines to opioid peptides.P-glycoprotein trafficking as a therapeutic target to optimize CNS drug delivery.Structure-Activity Relationships of [des-Arg7]Dynorphin A Analogues at the κ Opioid Receptor.Evaluation of the Biological Properties and the Enzymatic Stability of Glycosylated Luteinizing Hormone-Releasing Hormone AnalogsSynthesis, biological evaluation and structural characterization of novel glycopeptide analogues of nociceptin N/OFQ.Discovery of Novel Multifunctional Ligands with μ/δ Opioid Agonist/Neurokinin-1 (NK1) Antagonist Activities for the Treatment of Pain.Effect of peptide agonists of peripheral opioid receptors on operant feeding behavior and food motivation in rats.
P2860
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P2860
Improving metabolic stability by glycosylation: bifunctional peptide derivatives that are opioid receptor agonists and neurokinin 1 receptor antagonists
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
Improving metabolic stability ...... rokinin 1 receptor antagonists
@ast
Improving metabolic stability ...... rokinin 1 receptor antagonists
@en
type
label
Improving metabolic stability ...... rokinin 1 receptor antagonists
@ast
Improving metabolic stability ...... rokinin 1 receptor antagonists
@en
prefLabel
Improving metabolic stability ...... rokinin 1 receptor antagonists
@ast
Improving metabolic stability ...... rokinin 1 receptor antagonists
@en
P2093
P2860
P356
P1476
Improving metabolic stability ...... rokinin 1 receptor antagonists
@en
P2093
Edita Navratilova
Frank Porreca
Henry I Yamamura
Josef Vagner
Josephine Lai
Neil E Jacobsen
Padma Nair
Shou-Wu Ma
Takashi Yamamoto
P2860
P304
P356
10.1021/JM900473P
P407
P577
2009-08-01T00:00:00Z