The endosomal protein-sorting receptor sortilin has a role in trafficking α-1 antitrypsin - Wikidata - awgldk - TriplyDB

The endosomal protein-sorting receptor sortilin has a role in trafficking α-1 antitrypsin

The endosomal protein-sorting receptor sortilin has a role in trafficking α-1 antitrypsin

http://www.wikidata.org/entity/Q36466323

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Capitalizing on the autophagic response for treatment of liver disease caused by alpha-1-antitrypsin deficiency and other genetic diseases Alpha-1-antitrypsin deficiency Fluphenazine reduces proteotoxicity in C. elegans and mammalian models of alpha-1-antitrypsin deficiency FBG1 Is the Final Arbitrator of A1AT-Z Degradation The BiP molecular chaperone plays multiple roles during the biogenesis of torsinA, an AAA+ ATPase associated with the neurological disease early-onset torsion dystonia.Sortilin Fragments Deposit at Senile Plaques in Human Cerebrum ERAD defects and the HFE-H63D variant are associated with increased risk of liver damages in Alpha 1-Antitrypsin Deficiency Targeting intracellular degradation pathways for treatment of liver disease caused by α1-antitrypsin deficiency Secretion of a foreign protein from budding yeasts is enhanced by cotranslational translocation and by suppression of vacuolar targeting.Energy landscapes of functional proteins are inherently risky.Sortilin and lipoprotein metabolism: making sense out of complexity.The Lhs1/GRP170 chaperones facilitate the endoplasmic reticulum-associated degradation of the epithelial sodium channel Disorders of protein misfolding: alpha-1-antitrypsin deficiency as prototype.α1-antitrypsin Deficiency: A Misfolded Secretory Protein Variant with Unique Effects on the Endoplasmic Reticulum.Mysteries of α1-antitrypsin deficiency: emerging therapeutic strategies for a challenging disease.Early-onset torsion dystonia: a novel high-throughput yeast genetic screen for factors modifying protein levels of torsinAΔE.Endoplasmic reticulum-associated degradation of the renal potassium channel, ROMK, leads to type II Bartter syndrome.Neurodegeneration-associated mutant TREM2 proteins abortively cycle between the ER and ER-Golgi intermediate compartment.SERPINA1 and MAN1B1 polymorphisms are not linked to severe liver disease in a French cohort of alpha-1 antitrypsin deficiency children.Endoplasmic reticulum turnover: ER-phagy and other flavors in selective and non-selective ER clearance.

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The endosomal protein-sorting receptor sortilin has a role in trafficking α-1 antitrypsin

http://www.wikidata.org/entity/Q36466323

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2012 nî lūn-bûn

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The endosomal protein-sorting receptor sortilin has a role in trafficking α-1 antitrypsin

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The endosomal protein-sorting receptor sortilin has a role in trafficking α-1 antitrypsin

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type

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The endosomal protein-sorting receptor sortilin has a role in trafficking α-1 antitrypsin

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The endosomal protein-sorting receptor sortilin has a role in trafficking α-1 antitrypsin

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The endosomal protein-sorting receptor sortilin has a role in trafficking α-1 antitrypsin

@ast

The endosomal protein-sorting receptor sortilin has a role in trafficking α-1 antitrypsin

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GENETICS.112.143487

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P1476

The endosomal protein-sorting receptor sortilin has a role in trafficking α-1 antitrypsin

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P2093

Cristy L Gelling

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David H Perlmutter

http://www.w3.org/2001/XMLSchema#string

Ian W Dawes

http://www.w3.org/2001/XMLSchema#string

Jeffrey L Brodsky

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P2860

The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein

Grp78, Grp94, and Grp170 interact with alpha1-antitrypsin mutants that are retained in the endoplasmic reticulum

Characterization of an ERAD gene as VPS30/ATG6 reveals two alternative and functionally distinct protein quality control pathways: one for soluble Z variant of human alpha-1 proteinase inhibitor (A1PiZ) and another for aggregates of A1PiZ.

Biological, clinical and population relevance of 95 loci for blood lipids

From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus

Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans

Genomewide association analysis of coronary artery disease

Functional profiling of the Saccharomyces cerevisiae genome

Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis

Gene-enzyme relationship in the sulfate assimilation pathway of Saccharomyces cerevisiae. Study of the 3'-phosphoadenylylsulfate reductase structural gene.

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889-903

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scholarly article

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10.1534/GENETICS.112.143487

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3

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192

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Edward A Fisher

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2012-08-24T00:00:00Z

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22923381

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3522165

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