BCR-signaling-induced cell death demonstrates dependency on multiple BH3-only proteins in a murine model of B-cell lymphoma.

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PI3Kδ inhibition elicits anti-leukemic effects through Bim-dependent apoptosis MYC selects against reduced BCL2A1/A1 protein expression during B cell lymphomagenesis.Functional disparities among BCL-2 members in tonsillar and leukemic B-cell subsets assessed by BH3-mimetic profiling.

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BCR-signaling-induced cell death demonstrates dependency on multiple BH3-only proteins in a murine model of B-cell lymphoma.

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2015 nî lūn-bûn

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2015年の論文

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2015年学术文章

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BCR-signaling-induced cell dea ...... rine model of B-cell lymphoma.

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BCR-signaling-induced cell dea ...... rine model of B-cell lymphoma.

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BCR-signaling-induced cell dea ...... rine model of B-cell lymphoma.

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BCR-signaling-induced cell dea ...... rine model of B-cell lymphoma.

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BCR-signaling-induced cell dea ...... rine model of B-cell lymphoma.

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BCR-signaling-induced cell dea ...... rine model of B-cell lymphoma.

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P1476

BCR-signaling-induced cell dea ...... urine model of B-cell lymphoma

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C L Scott

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K L Cox

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L Happo

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M J Carter

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P2860

An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9

Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria

Tyrosine residues in phospholipase Cgamma 2 essential for the enzyme function in B-cell signaling

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

Apoptosis via the B cell antigen receptor requires Bax translocation and involves mitochondrial depolarization, cytochrome C release, and caspase-9 activation

BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alpha

BH3 domains other than Bim and Bid can directly activate Bax/Bak

Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

P2888

cdd.2015.97

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303-312

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10.1038/CDD.2015.97

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BCR-signaling-induced cell death demonstrates dependency on multiple BH3-only proteins in a murine model of B-cell lymphoma.

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P2860

P2860

BCR-signaling-induced cell death demonstrates dependency on multiple BH3-only proteins in a murine model of B-cell lymphoma.

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