Semi-Mechanism-Based Population Pharmacokinetic Modeling of the Hedgehog Pathway Inhibitor Vismodegib

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A survey of renal impairment pharmacokinetic studies for new oncology drug approvals in the USA from 2010 to early 2015: a focus on development strategies and future directions Pharmacokinetics and safety of vismodegib in patients with advanced solid malignancies and hepatic impairment.

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Semi-Mechanism-Based Population Pharmacokinetic Modeling of the Hedgehog Pathway Inhibitor Vismodegib

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2015 nî lūn-bûn

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2015年の論文

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2015年学术文章

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Semi-Mechanism-Based Populatio ...... g Pathway Inhibitor Vismodegib

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Semi-Mechanism-Based Populatio ...... g Pathway Inhibitor Vismodegib

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Semi-Mechanism-Based Populatio ...... g Pathway Inhibitor Vismodegib

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Semi-Mechanism-Based Populatio ...... g Pathway Inhibitor Vismodegib

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B Wang

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J Y Jin

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M Dresser

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R A Graham

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T Lu

http://www.w3.org/2001/XMLSchema#string

Y Gao

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P2860

A mammalian patched homolog is expressed in target tissues of sonic hedgehog and maps to a region associated with developmental abnormalities

Pharmacokinetics of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with locally advanced or metastatic solid tumors: the role of alpha-1-acid glycoprotein binding

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

Human homolog of patched, a candidate gene for the basal cell nevus syndrome

Prediction-corrected visual predictive checks for diagnosing nonlinear mixed-effects models.

Population pharmacokinetic analysis of ropivacaine and its metabolite 2',6'-pipecoloxylidide from pooled data in neonates, infants, and children.

Inhibition of the hedgehog pathway in advanced basal-cell carcinoma.

Changes in plasma protein binding have little clinical relevance.

Human alpha-1-glycoprotein and its interactions with drugs.

Essential role of stromally induced hedgehog signaling in B-cell malignancies.

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scholarly article

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10.1002/PSP4.12039

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Semi-Mechanism-Based Population Pharmacokinetic Modeling of the Hedgehog Pathway Inhibitor Vismodegib

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P2860

P2860

Semi-Mechanism-Based Population Pharmacokinetic Modeling of the Hedgehog Pathway Inhibitor Vismodegib

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