Cannabinoids induce pancreatic β-cell death by directly inhibiting insulin receptor activation.
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Human β-cell proliferation and intracellular signaling: part 3Endocannabinoid regulation of β-cell functions: implications for glycaemic control and diabetesActivation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes.The cannabinoid ligand LH-21 reduces anxiety and improves glucose handling in diet-induced obese pre-diabetic mice.New insights on the role of the endocannabinoid system in the regulation of energy balance.Effects of CB1 receptor blockade on monosodium glutamate induced hypometabolic and hypothalamic obesity in rats.Gαi/o-coupled receptor signaling restricts pancreatic β-cell expansionAlterations in the Medullary Endocannabinoid System Contribute to Age-related Impairment of Baroreflex Sensitivity.The cannabinoid CB1 receptor and mTORC1 signalling pathways interact to modulate glucose homeostasis in mice.Cannabinoids Regulate Bcl-2 and Cyclin D2 Expression in Pancreatic β Cells.Human β-cell proliferation and intracellular signaling: driving in the dark without a road map.Fetal endocannabinoids orchestrate the organization of pancreatic islet microarchitectureControlled downregulation of the cannabinoid CB1 receptor provides a promising approach for the treatment of obesity and obesity-derived type 2 diabetes.Blockade of cannabinoid 1 receptor improves GLP-1R mediated insulin secretion in mice.Prolonged activation of human islet cannabinoid receptors in vitro induces adaptation but not dysfunction.Metabolic effects of chronic cannabis smokingRole of the endocannabinoid system in diabetes and diabetic complications.Human CB1 Receptor Isoforms, present in Hepatocytes and β-cells, are Involved in Regulating MetabolismCB1 cannabinoid receptors couple to focal adhesion kinase to control insulin release.New vistas for treatment of obesity and diabetes? Endocannabinoid signalling and metabolism in the modulation of energy balance.Modulation of β-cell function: a translational journey from the bench to the bedside.A novel peripheral cannabinoid receptor 1 antagonist, BPR0912, reduces weight independently of food intake and modulates thermogenesis.Blockade of cannabinoid 1 receptor improves glucose responsiveness in pancreatic beta cells.Overactivation of the endocannabinoid system alters the antilipolytic action of insulin in mouse adipose tissue.Absence of cannabinoid 1 receptor in beta cells protects against high-fat/high-sugar diet-induced beta cell dysfunction and inflammation in murine islets.Glucose Controls the Expression of Polypyrimidine Tract-Binding Protein 1 via the Insulin Receptor Signaling Pathway in Pancreatic β Cells
P2860
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P2860
Cannabinoids induce pancreatic β-cell death by directly inhibiting insulin receptor activation.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Cannabinoids induce pancreatic ...... g insulin receptor activation.
@ast
Cannabinoids induce pancreatic ...... g insulin receptor activation.
@en
type
label
Cannabinoids induce pancreatic ...... g insulin receptor activation.
@ast
Cannabinoids induce pancreatic ...... g insulin receptor activation.
@en
prefLabel
Cannabinoids induce pancreatic ...... g insulin receptor activation.
@ast
Cannabinoids induce pancreatic ...... g insulin receptor activation.
@en
P2093
P2860
P921
P1433
P1476
Cannabinoids induce pancreatic ...... g insulin receptor activation.
@en
P2093
Eun Kyung Lee
Olga D Carlson
Qizong Lao
Rohit N Kulkarni
Yu-Kyong Shin
P2860
P356
10.1126/SCISIGNAL.2002519
P577
2012-03-20T00:00:00Z