p16INK4a induces an age-dependent decline in islet regenerative potential
about
Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive valueChromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL ExpressionINK4/ARF transcript expression is associated with chromosome 9p21 variants linked to atherosclerosisTelomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancerTumor suppressors: enhancers or suppressors of regeneration?Cellular senescence and tumor suppressor gene p16FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasisTelomerase deficiency impairs glucose metabolism and insulin secretionRemodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and agingExpression of p16(INK4a) in peripheral blood T-cells is a biomarker of human agingEpigenetics: a molecular link between environmental factors and type 2 diabetesHmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf ExpressionThe Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cellsMolecular dissection of formation of senescence-associated heterochromatin fociRapid asymmetric evolution of a dual-coding tumor suppressor INK4a/ARF locus contradicts its function"Inflammaging" as a Druggable Target: A Senescence-Associated Secretory Phenotype-Centered View of Type 2 DiabetesCellular senescence in aging and age-related disease: from mechanisms to therapyChanges in Regenerative Capacity through LifespanNoncoding RNA control of cellular senescenceLong non-coding RNAs as regulators of the endocrine systemNutrition, epigenetics, and metabolic syndromeβ-cell dedifferentiation in diabetes is important, but what is it?Therapeutic targeting of replicative immortalityReproductive Aging Drives Protein Accumulation in the Uterus and Limits Lifespan in C. elegansCeramide transfer protein deficiency compromises organelle function and leads to senescence in primary cellsHuman UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells.Role of lncRNAs in Cellular AgingTargeting CDK4 and CDK6: From Discovery to TherapyImmortalization eliminates a roadblock during cellular reprogramming into iPS cellsAge-related changes of germline stem cell activity, niche signaling activity and egg production in DrosophilaDeletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell lossThe epigenomics of cancerImpact of genomic damage and ageing on stem cell functionDefining the toxicology of agingANRIL: molecular mechanisms and implications in human healthRNA-binding protein Musashi1 modulates glioma cell growth through the post-transcriptional regulation of Notch and PI3 kinase/Akt signaling pathwaysc-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16INK4a expressionActivin B receptor ALK7 is a negative regulator of pancreatic beta-cell functionSox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cellsCyclin A is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells
P2860
Q21092217-91D95A8B-ADDF-443C-83F3-5C32B6762A80Q21092443-A5523A59-4A99-4007-91B7-12D9814B4904Q21562488-93B27ED3-CFE1-45D9-972C-684A0D97F933Q24615809-2528C1FA-EA45-489C-9795-AFD059DC991BQ24618747-52486666-E631-4033-9CBD-70DEE58B7A67Q24629853-37D9FFAC-09C8-4E19-B757-50D4AA704F4CQ24630630-D28070C3-8A39-4C62-B445-4ACB70FAF930Q24633376-A0E8CFD2-BA80-47AB-83F5-ACBE196682F1Q24642706-F2613019-3603-4D33-A11D-4FCBAA971502Q24646862-B82CB52B-3237-41F1-938C-48DD93E2385FQ24652830-AB55231F-5264-4157-93A1-E66EC16473A1Q24658265-3C74C4D1-F589-4F47-8E9D-9D5F787B742DQ24680814-FFD499A3-8366-466B-88D5-F438A5A14AEBQ24681416-98BA92C3-0CDC-4182-9771-B88218494099Q24682671-9ABB94CC-82BE-427B-9420-5ACF86895A7CQ26747251-7690B264-F85D-4738-AE6B-6DF7487A529CQ26773500-E69BE45D-79B3-46F3-8F86-61F770466960Q26778013-9F14A4B7-C95D-4B43-85F0-96204971374CQ26786557-268FAADA-290D-43E3-9FD0-5513E39AF281Q26827949-15F862C8-B08F-438C-AA9B-7A79E2555049Q26829684-41606E4C-7657-41B9-9957-2A8680861CAEQ27011272-554085BE-BD13-4013-98B0-CBD34C95A7A7Q27027457-9622BCA9-C90D-44FA-856F-DD5720A27873Q27309712-93B2D54E-4F3E-421D-B773-DB834B19E72DQ27314745-1D0AA6E3-B744-41E8-B9AF-2C32825274A3Q27934187-FA29EC74-F0C7-4BDC-A7DA-4E0257DC47B4Q28078986-E538680D-690A-4BAB-9A94-EF50CFFD47DEQ28082912-58183562-15B0-4F7C-B69D-FD5FDDA964C5Q28254388-0C13E9B1-F3AC-4449-AB92-B25DC1C227D6Q28268319-EA4ECF76-9A3A-4283-A84A-4ECA6571EBB8Q28274165-CB198E51-CBFF-4C07-B500-1EA268E74581Q28289975-6629A80C-DA79-468F-AFF8-6DF37C721A5EQ28308125-2EC92658-E8F2-4E78-967E-AF3DE130D713Q28389491-96CEAA20-7700-4B2B-BA58-86EBC80005BCQ28394102-2A742C0C-5EA1-49DC-97BC-9031ED0DF5CDQ28481458-C630DC4B-F418-4727-BB28-F939BA2578CCQ28504995-B58A77DD-592D-491D-9CDF-D8D547C307CAQ28512951-6226DE6E-BE21-4903-A460-878B3DEE552EQ28513079-C0F5551E-D0E3-40E7-8887-73501FA4AACFQ28590731-4CD4B5A2-F92F-48A6-BB15-EA2EFC1972CB
P2860
p16INK4a induces an age-dependent decline in islet regenerative potential
description
2006 nî lūn-bûn
@nan
2006 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
p16INK4a induces an age-dependent decline in islet regenerative potential
@ast
p16INK4a induces an age-dependent decline in islet regenerative potential
@en
p16INK4a induces an age-dependent decline in islet regenerative potential
@nl
type
label
p16INK4a induces an age-dependent decline in islet regenerative potential
@ast
p16INK4a induces an age-dependent decline in islet regenerative potential
@en
p16INK4a induces an age-dependent decline in islet regenerative potential
@nl
prefLabel
p16INK4a induces an age-dependent decline in islet regenerative potential
@ast
p16INK4a induces an age-dependent decline in islet regenerative potential
@en
p16INK4a induces an age-dependent decline in islet regenerative potential
@nl
P2093
P50
P356
P1433
P1476
p16INK4a induces an age-dependent decline in islet regenerative potential
@en
P2093
Angela Koh
Chad Torrice
Janakiraman Krishnamurthy
P2888
P356
10.1038/NATURE05092
P407
P577
2006-09-28T00:00:00Z
P6179
1050343906