Synthetic drugs and natural products as modulators of constitutive androstane receptor (CAR) and pregnane X receptor (PXR).
about
Marine invertebrate xenobiotic-activated nuclear receptors: their application as sensor elements in high-throughput bioassays for marine bioactive compoundsInduction of nuclear translocation of constitutive androstane receptor by peroxisome proliferator-activated receptor alpha synthetic ligands in mouse liverActivation of xenobiotic receptors: driving into the nucleus.Marine and semi-synthetic hydroxysteroids as new scaffolds for pregnane X receptor modulationActivation of CAR and PXR by Dietary, Environmental and Occupational Chemicals Alters Drug Metabolism, Intermediary Metabolism, and Cell Proliferation.Rational quantitative structure-activity relationship (RQSAR) screen for PXR and CAR isoform-specific nuclear receptor ligands.Helix 11 dynamics is critical for constitutive androstane receptor activity.Xenobiotic metabolism, disposition, and regulation by receptors: from biochemical phenomenon to predictors of major toxicitiesHelicobacter hepaticus--induced liver tumor promotion is associated with increased serum bile acid and a persistent microbial-induced immune response.Modulation of constitutive androstane receptor (CAR) and pregnane X receptor (PXR) by 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives, ligands of peripheral benzodiazepine receptor (PBR).Differential activation of human constitutive androstane receptor and its SV23 and SV24 splice variants by rilpivirine and etravirineFamilies of nuclear receptors in vertebrate models: characteristic and comparative toxicological perspectiveOrtho-aminoazotoluene activates mouse constitutive androstane receptor (mCAR) and increases expression of mCAR target genes.Multi-species analyses of direct activators of the constitutive androstane receptor.Immunological response as a source to variability in drug metabolism and transport.Screening Ingredients from Herbs against Pregnane X Receptor in the Study of Inductive Herb-Drug Interactions: Combining Pharmacophore and Docking-Based Rank Aggregation.The environmental estrogen, nonylphenol, activates the constitutive androstane receptor.Deciphering the roles of the constitutive androstane receptor in energy metabolism.Rapid clinical induction of hepatic cytochrome P4502B6 activity by ritonavirMachine learning methods and docking for predicting human pregnane X receptor activation.Antiretroviral drug transporters and metabolic enzymes in human testicular tissue: potential contribution to HIV-1 sanctuary site.Identification of Ginkgo biloba as a novel activator of pregnane X receptor.Induction of P-glycoprotein by antiretroviral drugs in human brain microvessel endothelial cells.Piperine activates human pregnane X receptor to induce the expression of cytochrome P450 3A4 and multidrug resistance protein 1A concentration addition model for the activation of the constitutive androstane receptor by xenobiotic mixtures.Activation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) by herbal medicines.The human constitutive androstane receptor promotes the differentiation and maturation of hepatic-like cells.Xenobiotic Receptor-Mediated Regulation of Intestinal Barrier Function and Innate Immunity.Induction of cytochrome P450 enzymes: a view on human in vivo findings.Mechanisms of xenobiotic receptor activation: Direct vs. indirect.The regulation of human hepatic drug transporter expression by activation of xenobiotic-sensing nuclear receptors.Identification of three novel natural product compounds that activate PXR and CAR and inhibit inflammationEffect of aflatoxin B1 on nuclear receptors PXR, CAR, and AhR and their target cytochromes P450 mRNA expression in primary cultures of human hepatocytes.Sex-Differential Responses of Tumor Promotion-Associated Genes and Dysregulation of Novel Long Noncoding RNAs in Constitutive Androstane Receptor-Activated Mouse Liver.Effect of glycyrrhizin on CYP2C19 and CYP3A4 activity in healthy volunteers with different CYP2C19 genotypes.In vivo induction of P-glycoprotein expression at the mouse blood-brain barrier: an intracerebral microdialysis study.The mycotoxin, patulin, increases the expression of PXR and AhR and their target cytochrome P450s in primary cultured human hepatocytes.The Role of PXR Genotype and Transporter Expression in the Placental Transport of Lopinavir in Mice.Vitamin C protects piglet liver against zearalenone-induced oxidative stress by modulating expression of nuclear receptors PXR and CAR and their target genes.Impact of CAR agonist ligand TCPOBOP on mouse liver chromatin accessibility.
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P2860
Synthetic drugs and natural products as modulators of constitutive androstane receptor (CAR) and pregnane X receptor (PXR).
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh
2006年學術文章
@zh-hant
name
Synthetic drugs and natural pr ...... and pregnane X receptor (PXR).
@ast
Synthetic drugs and natural pr ...... and pregnane X receptor (PXR).
@en
type
label
Synthetic drugs and natural pr ...... and pregnane X receptor (PXR).
@ast
Synthetic drugs and natural pr ...... and pregnane X receptor (PXR).
@en
prefLabel
Synthetic drugs and natural pr ...... and pregnane X receptor (PXR).
@ast
Synthetic drugs and natural pr ...... and pregnane X receptor (PXR).
@en
P2860
P1476
Synthetic drugs and natural pr ...... and pregnane X receptor (PXR).
@en
P2093
Thomas K H Chang
P2860
P356
10.1080/03602530600569828
P407
P577
2006-01-01T00:00:00Z