Activation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) by herbal medicines.
about
Cross-talk between bile acids and gastrointestinal tract for progression and development of cancer and its therapeutic implicationsTargeting xenobiotic receptors PXR and CAR for metabolic diseasesGarlic extract diallyl sulfide (DAS) activates nuclear receptor CAR to induce the Sult1e1 gene in mouse liver.Thiazide-like diuretic drug metolazone activates human pregnane X receptor to induce cytochrome 3A4 and multidrug-resistance protein 1.RBCK1, an E3 ubiquitin ligase, interacts with and ubiquinates the human pregnane X receptor.Tryptophan 299 is a conserved residue of human pregnane X receptor critical for the functional consequence of ligand binding.Xenobiotic-sensing nuclear receptors involved in drug metabolism: a structural perspectiveNuclear Receptors in Drug Metabolism, Drug Response and Drug Interactions.Piperine activates human pregnane X receptor to induce the expression of cytochrome P450 3A4 and multidrug resistance protein 1Differential regulation of CYP3A4 promoter activity by a new class of natural product derivatives binding to pregnane X receptor.Insight into the metabolic mechanism of scoparone on biomarkers for inhibiting Yanghuang syndromeXenobiotic Receptor-Mediated Regulation of Intestinal Barrier Function and Innate Immunity.Flame retardant BDE-47 effectively activates nuclear receptor CAR in human primary hepatocytes.Nuclear receptor PXR, transcriptional circuits and metabolic relevance.Bile acid receptors as targets for drug development.The regulation of human hepatic drug transporter expression by activation of xenobiotic-sensing nuclear receptors.Effects of bile acids on neurological function and disease.TRIENNIAL LACTATION SYMPOSIUM: Nutrigenomics in dairy cows: Nutrients, transcription factors, and techniques.Identification of three novel natural product compounds that activate PXR and CAR and inhibit inflammationProtective effect of Calculus Bovis Sativus on intrahepatic cholestasis in rats induced by α-naphthylisothiocyanate.Expression of CYP3A in chronic ethanol-fed mice is mediated by endogenous pregnane X receptor ligands formed by enhanced cholesterol metabolism.Bilirubin clearance and antioxidant activities of ethanol extract of Phyllanthus amarus root in phenylhydrazine-induced neonatal jaundice in mice.Assessment of a pharmacokinetic and pharmacodynamic interaction between simvastatin and Ginkgo biloba extracts in healthy subjects.Role of pregnane X-receptor in regulating bacterial translocation in chronic liver diseases.Genetic variations of the xenoreceptors NR1I2 and NR1I3 and their effect on drug disposition and response variability.
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P2860
Activation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) by herbal medicines.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 18 August 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Activation of pregnane X recep ...... tor (CAR) by herbal medicines.
@en
Activation of pregnane X receptor
@nl
type
label
Activation of pregnane X recep ...... tor (CAR) by herbal medicines.
@en
Activation of pregnane X receptor
@nl
prefLabel
Activation of pregnane X recep ...... tor (CAR) by herbal medicines.
@en
Activation of pregnane X receptor
@nl
P2860
P1433
P1476
Activation of pregnane X recep ...... tor (CAR) by herbal medicines.
@en
P2093
Thomas K H Chang
P2860
P2888
P304
P356
10.1208/S12248-009-9135-Y
P407
P577
2009-08-18T00:00:00Z
P5875
P6179
1043111782