Activation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) by herbal medicines. - Wikidata - awgldk - TriplyDB

Activation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) by herbal medicines.

Activation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) by herbal medicines.

http://www.wikidata.org/entity/Q37378074

about

Cross-talk between bile acids and gastrointestinal tract for progression and development of cancer and its therapeutic implications Targeting xenobiotic receptors PXR and CAR for metabolic diseases Garlic extract diallyl sulfide (DAS) activates nuclear receptor CAR to induce the Sult1e1 gene in mouse liver.Thiazide-like diuretic drug metolazone activates human pregnane X receptor to induce cytochrome 3A4 and multidrug-resistance protein 1.RBCK1, an E3 ubiquitin ligase, interacts with and ubiquinates the human pregnane X receptor.Tryptophan 299 is a conserved residue of human pregnane X receptor critical for the functional consequence of ligand binding.Xenobiotic-sensing nuclear receptors involved in drug metabolism: a structural perspective Nuclear Receptors in Drug Metabolism, Drug Response and Drug Interactions.Piperine activates human pregnane X receptor to induce the expression of cytochrome P450 3A4 and multidrug resistance protein 1 Differential regulation of CYP3A4 promoter activity by a new class of natural product derivatives binding to pregnane X receptor.Insight into the metabolic mechanism of scoparone on biomarkers for inhibiting Yanghuang syndrome Xenobiotic Receptor-Mediated Regulation of Intestinal Barrier Function and Innate Immunity.Flame retardant BDE-47 effectively activates nuclear receptor CAR in human primary hepatocytes.Nuclear receptor PXR, transcriptional circuits and metabolic relevance.Bile acid receptors as targets for drug development.The regulation of human hepatic drug transporter expression by activation of xenobiotic-sensing nuclear receptors.Effects of bile acids on neurological function and disease.TRIENNIAL LACTATION SYMPOSIUM: Nutrigenomics in dairy cows: Nutrients, transcription factors, and techniques.Identification of three novel natural product compounds that activate PXR and CAR and inhibit inflammation Protective effect of Calculus Bovis Sativus on intrahepatic cholestasis in rats induced by α-naphthylisothiocyanate.Expression of CYP3A in chronic ethanol-fed mice is mediated by endogenous pregnane X receptor ligands formed by enhanced cholesterol metabolism.Bilirubin clearance and antioxidant activities of ethanol extract of Phyllanthus amarus root in phenylhydrazine-induced neonatal jaundice in mice.Assessment of a pharmacokinetic and pharmacodynamic interaction between simvastatin and Ginkgo biloba extracts in healthy subjects.Role of pregnane X-receptor in regulating bacterial translocation in chronic liver diseases.Genetic variations of the xenoreceptors NR1I2 and NR1I3 and their effect on drug disposition and response variability.

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Activation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) by herbal medicines.

http://www.wikidata.org/entity/Q37378074

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 18 August 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Activation of pregnane X recep ...... tor (CAR) by herbal medicines.

@en

Activation of pregnane X receptor

@nl

type

label

Activation of pregnane X recep ...... tor (CAR) by herbal medicines.

@en

Activation of pregnane X receptor

@nl

prefLabel

Activation of pregnane X recep ...... tor (CAR) by herbal medicines.

@en

Activation of pregnane X receptor

@nl

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S12248-009-9135-Y

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The AAPS Journal

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Activation of pregnane X recep ...... tor (CAR) by herbal medicines.

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Thomas K H Chang

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SXR, a novel steroid and xenobiotic-sensing nuclear receptor

2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements

Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene

Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

The pharmacognosy of Humulus lupulus L. (hops) with an emphasis on estrogenic properties

The human orphan receptor PXR messenger RNA is expressed in both normal and neoplastic breast tissue

Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes

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s12248-009-9135-y

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590-601

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10.1208/S12248-009-9135-Y

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