T cell positive selection by a high density, low affinity ligand
about
Mimotopes for alloreactive and conventional T cells in a peptide-MHC display libraryUsing a baculovirus display library to identify MHC class I mimotopes.T cells in mice expressing a transgenic human TCR beta chain get positively selected but cannot be activated in the periphery by signaling through TCR.Use of baculovirus MHC/peptide display libraries to characterize T-cell receptor ligands.Foxp1 is an essential transcriptional regulator for the generation of quiescent naive T cells during thymocyte development.Discrepancy between ELISPOT IFN-gamma secretion and binding of A2/peptide multimers to TCR reveals interclonal dissociation of CTL effector function from TCR-peptide/MHC complexes half-lifeDissociation of peripheral T cell responses from thymocyte negative selection by weak agonists supports a spare receptor model of T cell activation.Modulation of CD4 T cell function by soluble MHC II-peptide chimeras.Models of self-peptide sampling by developing T cells identify candidate mechanisms of thymic selection.Improving antigenic peptide vaccines for cancer immunotherapy using a dominant tumor-specific T cell receptor.Evolution of antigen-specific T cell receptors in vivo: preimmune and antigen-driven selection of preferred complementarity-determining region 3 (CDR3) motifsA kinetic threshold between negative and positive selection based on the longevity of the T cell receptor-ligand complex.Preselection thymocytes are more sensitive to T cell receptor stimulation than mature T cellsPotent T cell activation with dimeric peptide-major histocompatibility complex class II ligand: the role of CD4 coreceptor.An inverse relationship between T cell receptor affinity and antigen dose during CD4(+) T cell responses in vivo and in vitroB Cell Receptor Affinity for Insulin Dictates Autoantigen Acquisition and B Cell Functionality in Autoimmune Diabetes.Molecular and genetic parameters defining T-cell clonal selection.Generation of Peptides That Promote Positive Selection in the Thymus.TCR/pMHC Interaction: Phenotypic Model for an Unsolved Enigma.Increased Effector Memory Insulin-Specific CD4+ T Cells Correlate With Insulin Autoantibodies in Patients With Recent-Onset Type 1 Diabetes.The influence of the thymic environment on the CD4-versus-CD8 T lineage decision.
P2860
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P2860
T cell positive selection by a high density, low affinity ligand
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
T cell positive selection by a high density, low affinity ligand
@ast
T cell positive selection by a high density, low affinity ligand
@en
type
label
T cell positive selection by a high density, low affinity ligand
@ast
T cell positive selection by a high density, low affinity ligand
@en
prefLabel
T cell positive selection by a high density, low affinity ligand
@ast
T cell positive selection by a high density, low affinity ligand
@en
P2093
P2860
P356
P1476
T cell positive selection by a high density, low affinity ligand
@en
P2093
P2860
P304
P356
10.1073/PNAS.95.8.4522
P407
P577
1998-04-01T00:00:00Z