Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection
about
Cholesterol and ORP1L-mediated ER contact sites control autophagosome transport and fusion with the endocytic pathway.Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathwayEhNPC1 and EhNPC2 Proteins Participate in Trafficking of Exogenous Cholesterol in Entamoeba histolytica Trophozoites: Relevance for Phagocytosis.Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells.The Glycoproteins of All Filovirus Species Use the Same Host Factors for Entry into Bat and Human Cells but Entry Efficiency Is Species Dependent.Heat Shock Protein Beta-1 Modifies Anterior to Posterior Purkinje Cell Vulnerability in a Mouse Model of Niemann-Pick Type C DiseaseThe Niemann-Pick C1 Inhibitor NP3.47 Enhances Gene Silencing Potency of Lipid Nanoparticles Containing siRNA.Acidic Ca2+ stores in neurodegeneration.Genetic and pharmacological evidence implicates cathepsins in Niemann-Pick C cerebellar degeneration.Clues to NPC1-mediated cholesterol export from lysosomes.Structure of human Niemann-Pick C1 protein.Clues to the mechanism of cholesterol transfer from the structure of NPC1 middle lumenal domain bound to NPC2.Lysosomal membrane glycoproteins bind cholesterol and contribute to lysosomal cholesterol export.The Tetherin Antagonism of the Ebola Virus Glycoprotein Requires an Intact Receptor-Binding Domain and Can Be Blocked by GP1-Specific Antibodies.Triazoles inhibit cholesterol export from lysosomes by binding to NPC1.Selective inhibition of Ebola entry with selective estrogen receptor modulators by disrupting the endolysosomal calcium.A novel approach to analyze lysosomal dysfunctions through subcellular proteomics and lipidomics: the case of NPC1 deficiency.Trifunctional lipid probes for comprehensive studies of single lipid species in living cells.Characterization of cholesterol homeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts reveals a Niemann-Pick disease type C-like phenotype with enhanced lysosomal Ca2+ storage.Sequestration of cholesterol within the host late endocytic pathway restricts liver-stage Plasmodium development.Necroptosis-like Neuronal Cell Death Caused by Cellular Cholesterol Accumulation.3.3 Å structure of Niemann-Pick C1 protein reveals insights into the function of the C-terminal luminal domain in cholesterol transport.Lysosome and endoplasmic reticulum quality control pathways in Niemann-Pick type C disease.Introducing inducible fluorescent split cholesterol oxidase to mammalian cells.Antiviral activity of cationic amphiphilic drugs.Continuous transport of a small fraction of plasma membrane cholesterol to endoplasmic reticulum regulates total cellular cholesterol.Hepatitis C virus replication depends on endosomal cholesterol homeostasis.A Carbon Nanotube Optical Reporter Maps Endolysosomal Lipid Flux.Generation of patient specific human neural stem cells from Niemann-Pick disease type C patient-derived fibroblasts.Target identification and mode of action of four chemically divergent drugs against Ebola virus infection.ATP-binding cassette transporter-2 (ABCA2) as a therapeutic target.Pharmacological blockade of cholesterol trafficking by cepharanthine in endothelial cells suppresses angiogenesis and tumor growth.Effects of cholesterol transport inhibitor U18666A on APP metabolism in rat primary astrocytes.mTORC1 activates SREBP-2 by suppressing cholesterol trafficking to lysosomes in mammalian cells.Modeling diseases in multiple mouse strains for precision medicine studies.Simultaneous Targeting of NPC1 and VDAC1 by Itraconazole Leads to Synergistic Inhibition of mTOR Signaling and Angiogenesis.Modulating cancer cell survival by targeting intracellular cholesterol transport.Large-scale computational drug repositioning to find treatments for rare diseases.The Rab11-binding protein RELCH/KIAA1468 controls intracellular cholesterol distribution.Statins Suppress Ebola Virus Infectivity by Interfering with Glycoprotein Processing.
P2860
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P2860
Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年学术文章
@wuu
2015年学术文章
@zh-cn
2015年学术文章
@zh-hans
2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
@yue
2015年學術文章
@zh
2015年學術文章
@zh-hant
name
Identification of NPC1 as the ...... rol export and Ebola infection
@ast
Identification of NPC1 as the ...... rol export and Ebola infection
@en
type
label
Identification of NPC1 as the ...... rol export and Ebola infection
@ast
Identification of NPC1 as the ...... rol export and Ebola infection
@en
prefLabel
Identification of NPC1 as the ...... rol export and Ebola infection
@ast
Identification of NPC1 as the ...... rol export and Ebola infection
@en
P2093
P2860
P356
P1433
P1476
Identification of NPC1 as the ...... rol export and Ebola infection
@en
P2093
Jef K De Brabander
Lina Abi-Mosleh
Michael S Brown
Qiren Liang
P2860
P356
10.7554/ELIFE.12177
P407
P577
2015-12-08T00:00:00Z