A physiologically based simulation approach for determining metabolic constants from gas uptake data.
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Development of a physiologically based pharmacokinetic model for methyl ethyl ketone in F344 ratsIn silico toxicology: simulating interaction thresholds for human exposure to mixtures of trichloroethylene, tetrachloroethylene, and 1,1,1-trichloroethane.Human physiologic factors in respiratory uptake of 1,3-butadiene.Physiologically based toxicokinetic modeling of 1,3-butadiene lung metabolism in mice becomes more important at low dosesPhysiologically based pharmacokinetic modeling of cyclohexane as a tool for integrating animal and human test data.PBPK modeling/Monte Carlo simulation of methylene chloride kinetic changes in mice in relation to age and acute, subchronic, and chronic inhalation exposure.Physiologically based pharmacokinetic model for the inhibition of acetylcholinesterase by organophosphate esters.1,3-Butadiene: linking metabolism, dosimetry, and mutation inductionPhysiologically Based Pharmacokinetic (PBPK) Modeling of Metabolic Pathways of Bromochloromethane in RatsCutting Edge PBPK Models and Analyses: Providing the Basis for Future Modeling Efforts and Bridges to Emerging Toxicology ParadigmsConsideration of the target organ toxicity of trichloroethylene in terms of metabolite toxicity and pharmacokinetics.Development and utilization of physiologically based pharmacokinetic models for toxicological applications.MEGen: A Physiologically Based Pharmacokinetic Model Generator.Pitfalls and related improvements of in vivo gas uptake pharmacokinetic experimental systems.Physiologically-based pharmacokinetic modeling and bioactivation of xenobiotics.Pharmacokinetic modeling approaches for describing the uptake, systemic distribution, and disposition of inhaled chemicals.Development of a physiologically based pharmacokinetic model for chlorobenzene in F-344 rats.Significance of the dermal route of exposure to risk assessment.Toxicokinetic Model Development for the Insensitive Munitions Component 2,4-Dinitroanisole.Toxicokinetic Model Development for the Insensitive Munitions Component 3-Nitro-1,2,4-Triazol-5-One.Quantitative Property-Property Relationship for Screening-Level Prediction of Intrinsic Clearance of Volatile Organic Chemicals in Rats and Its Integration within PBPK Models to Predict Inhalation Pharmacokinetics in Humans.Development of an inhalation physiologically based pharmacokinetic (PBPK) model for 2,2, 4-trimethylpentane (TMP) in male Long-Evans rats using gas uptake experiments.A physiologically based pharmacokinetic model for chloropentafluorobenzene in primates to be used in the evaluation of protective equipment against toxic gases.Incorporation of acute dynamic ventilation changes into a standardized physiologically based pharmacokinetic model.Development of a physiologically based pharmacokinetic model for decane, a constituent of jet propellent-8.Species and sex-dependent toxicokinetics of 1-bromopropane: the role of hepatic cytochrome P450 oxidation and glutathione (GSH).1,1,1-Trifluoro-2,2-dichloroethane (HCFC-123) and 1,1,1-trifluoro-2-bromo-2-chloroethane (halothane) cause similar biochemical effects in rats exposed by inhalation for five days.A physiologically based description of ethylene oxide dosimetry in the rat.Extrahepatic metabolism by CYP2E1 in PBPK modeling of lipophilic volatile organic chemicals: impacts on metabolic parameter estimation and prediction of dose metrics.Development of a physiologically based pharmacokinetic (PBPK) model for methyl iodide in rats, rabbits, and humans.A physiologically-based pharmacokinetic model assessment of methyl t-butyl ether in groundwater for a bathing and showering determination.Physiologically based pharmacokinetic analysis of the concentration-dependent metabolism of halothane.Exploration of an interaction threshold for the joint toxicity of trichloroethylene and 1,1-dichloroethylene: utilization of a PBPK model.Feasibility of metabolic parameter estimation in pharmacokinetic models of carbon tetrachloride exposure in rats1Modeling Kinetic Interactions of Chemical MixturesAssessing Kinetic Determinants for Metabolism and Oral Uptake of Octamethylcyclotetrasiloxane (D4) from Inhalation Chamber StudiesSensitivity Analysis and the Design of Gas Uptake Inhalation StudiesPhysiologically-Based Pharmacokinetic ModelingGas Uptake Inhalation Techniques and the Rates of Metabolism of Chloromethanes, Chloroethanes, and Chloroethylenes in the RatA Risk Assessment Approach for Nursing Infants Exposed to Volatile Organics through the Mother's Occupational Inhalation Exposure
P2860
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P2860
A physiologically based simulation approach for determining metabolic constants from gas uptake data.
description
1986 nî lūn-bûn
@nan
1986年の論文
@ja
1986年学术文章
@wuu
1986年学术文章
@zh-cn
1986年学术文章
@zh-hans
1986年学术文章
@zh-my
1986年学术文章
@zh-sg
1986年學術文章
@yue
1986年學術文章
@zh
1986年學術文章
@zh-hant
name
A physiologically based simula ...... onstants from gas uptake data.
@ast
A physiologically based simula ...... onstants from gas uptake data.
@en
type
label
A physiologically based simula ...... onstants from gas uptake data.
@ast
A physiologically based simula ...... onstants from gas uptake data.
@en
prefLabel
A physiologically based simula ...... onstants from gas uptake data.
@ast
A physiologically based simula ...... onstants from gas uptake data.
@en
P2093
P1476
A physiologically based simula ...... onstants from gas uptake data.
@en
P2093
Andersen ME
Clewell HJ 3rd
P304
P356
10.1016/0041-008X(86)90361-3
P577
1986-12-01T00:00:00Z