The quest for genetic determinants of human longevity: challenges and insights.
about
We are ageingPrevalence in the United States of selected candidate gene variants. Third National Health and Nutrition Examination Survey, 1991- 1994Evidence that the gene encoding insulin degrading enzyme influences human lifespanNext-generation sequencing in aging research: emerging applications, problems, pitfalls and possible solutionsAssociation of FOXO3A variation with human longevity confirmed in German centenariansFOXO3A genotype is strongly associated with human longevityDisruption of the Ang II type 1 receptor promotes longevity in miceAPOE genotype and stress response - a mini reviewLong live FOXO: unraveling the role of FOXO proteins in aging and longevityThe three genetics (nuclear DNA, mitochondrial DNA, and gut microbiome) of longevity in humans considered as metaorganismsThe search for longevity and healthy aging genes: insights from epidemiological studies and samples of long-lived individualsMISC-1/OGC links mitochondrial metabolism, apoptosis and insulin secretionThe increase of the functional entropy of the human brain with age.Socioeconomic status as a moderator between frailty and mortality at old agesGenetics of healthy aging and longevityExercise, APOE genotype, and the evolution of the human lifespanDesign, recruitment, logistics, and data management of the GEHA (Genetics of Healthy Ageing) projectGenetic signatures of exceptional longevity in humansA family longevity selection score: ranking sibships by their longevity, size, and availability for study.A comparative study of age-related hearing loss in wild type and insulin-like growth factor I deficient mice.Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studiesNegative selection on BRCA1 susceptibility alleles sheds light on the population genetics of late-onset diseases and aging theory.A hierarchical and modular approach to the discovery of robust associations in genome-wide association studies from pooled DNA samples.RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans.Biodemography of human ageingAssociation between FOXO3A gene polymorphisms and human longevity: a meta-analysis.High-density genomewide linkage analysis of exceptional human longevity identifies multiple novel loci.Adjustment for smoking does not alter the FOXO3A association with longevity.Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data.Clustering by genetic ancestry using genome-wide SNP data.APOE gene polymorphism in long-lived individuals from a central China population.Association between subjective well-being and exceptional longevity in a longevity town in China: a population-based study.The dynamic exome: acquired variants as individuals age.Beta2-adrenergic receptor gene polymorphisms as systemic determinants of healthy aging in an evolutionary context.Genetic variants influencing human aging from late-onset Alzheimer's disease (LOAD) genome-wide association studies (GWAS).Happy aged people are all alike, while every unhappy aged person is unhappy in its own wayHuman longevity and variation in DNA damage response and repair: study of the contribution of sub-processes using competitive gene-set analysis.Birth cohort differences in the prevalence of longevity-associated variants in APOE and FOXO3A in Danish long-lived individuals.HRAS1 and LASS1 with APOE are associated with human longevity and healthy aging.Longevity candidate genes and their association with personality traits in the elderly.
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P2860
The quest for genetic determinants of human longevity: challenges and insights.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh
2006年學術文章
@zh-hant
name
The quest for genetic determinants of human longevity: challenges and insights.
@ast
The quest for genetic determinants of human longevity: challenges and insights.
@en
type
label
The quest for genetic determinants of human longevity: challenges and insights.
@ast
The quest for genetic determinants of human longevity: challenges and insights.
@en
altLabel
The quest for genetic determinants of human longevity: challenges and insights
@en
prefLabel
The quest for genetic determinants of human longevity: challenges and insights.
@ast
The quest for genetic determinants of human longevity: challenges and insights.
@en
P2860
P356
P1476
The quest for genetic determinants of human longevity: challenges and insights.
@en
P2093
James W Vaupel
P2860
P2888
P304
P356
10.1038/NRG1871
P407
P577
2006-06-01T00:00:00Z
P5875
P6179
1041768780