β-Arrestin-biased agonism as the central mechanism of action for insulin-like growth factor 1 receptor-targeting antibodies in Ewing's sarcoma.
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β-arrestin1 at the cross-road of endothelin-1 signaling in cancerAdaptive resistance to targeted therapies in cancerCombinational Therapy Enhances the Effects of Anti-IGF-1R mAb Figitumumab to Target Small Cell Lung CancerCaveolin-1 promotes Ewing sarcoma metastasis regulating MMP-9 expression through MAPK/ERK pathwaySomething old, something new and something borrowed: emerging paradigm of insulin-like growth factor type 1 receptor (IGF-1R) signaling regulationAntitumor effects and molecular mechanisms of figitumumab, a humanized monoclonal antibody to IGF-1 receptor, in esophageal carcinoma.The association of TP53 mutations with the resistance of colorectal carcinoma to the insulin-like growth factor-1 receptor inhibitor picropodophyllin.Insulin/Insulin-like growth factors in cancer: new roles for the aryl hydrocarbon receptor, tumor resistance mechanisms, and new blocking strategies.OVA66 increases cell growth, invasion and survival via regulation of IGF-1R-MAPK signaling in human cancer cells.Role for engagement of β-arrestin2 by the transactivated EGFR in agonist-specific regulation of δ receptor activation of ERK1/2.TSH/IGF-1 Receptor Cross Talk in Graves' Ophthalmopathy Pathogenesis.Nuclear β-arrestin1 is a critical cofactor of hypoxia-inducible factor-1α signaling in endothelin-1-induced ovarian tumor progression.Metformin Enhances the Therapy Effects of Anti-IGF-1R mAb Figitumumab to NSCLC.Upregulation of neurovascular communication through filamin abrogation promotes ectopic periventricular neurogenesis.Targeted therapies for bone sarcomas.Blocking the road, stopping the engine or killing the driver? Advances in targeting EWS/FLI-1 fusion in Ewing sarcoma as novel therapy.Targeting the IGF-1R: The Tale of the Tortoise and the Hare.A Practical Guide to Approaching Biased Agonism at G Protein Coupled Receptors.Unbalancing p53/Mdm2/IGF-1R axis by Mdm2 activation restrains the IGF-1-dependent invasive phenotype of skin melanoma.Functional antagonism of β-arrestin isoforms balance IGF-1R expression and signalling with distinct cancer-related biological outcomes.Enhanced response of melanoma cells to MEK inhibitors following unbiased IGF-1R down-regulation.Insulin-like growth factor-1 receptor (IGF-1R) inhibition promotes expansion of human NK cells which maintain their potent antitumor activity against Ewing sarcoma cells.Personalized Medicine in Malignant Melanoma: Towards Patient Tailored Treatment.
P2860
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P2860
β-Arrestin-biased agonism as the central mechanism of action for insulin-like growth factor 1 receptor-targeting antibodies in Ewing's sarcoma.
description
2012 nî lūn-bûn
@nan
2012年の論文
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2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年学术文章
@zh-my
2012年学术文章
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2012年學術文章
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2012年學術文章
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2012年學術文章
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name
β-Arrestin-biased agonism as t ...... antibodies in Ewing's sarcoma.
@ast
β-Arrestin-biased agonism as t ...... antibodies in Ewing's sarcoma.
@en
type
label
β-Arrestin-biased agonism as t ...... antibodies in Ewing's sarcoma.
@ast
β-Arrestin-biased agonism as t ...... antibodies in Ewing's sarcoma.
@en
prefLabel
β-Arrestin-biased agonism as t ...... antibodies in Ewing's sarcoma.
@ast
β-Arrestin-biased agonism as t ...... antibodies in Ewing's sarcoma.
@en
P2093
P2860
P356
P1476
β-Arrestin-biased agonism as t ...... antibodies in Ewing's sarcoma.
@en
P2093
Ada Girnita
Claire Worrall
Hongchang Shen
Huiyuan Zheng
Iulian Oprea
Leonard Girnita
Radu Stefanescu
P2860
P304
20620-20625
P356
10.1073/PNAS.1216348110
P407
P577
2012-11-27T00:00:00Z