Blocking the road, stopping the engine or killing the driver? Advances in targeting EWS/FLI-1 fusion in Ewing sarcoma as novel therapy.
about
Combined experience of six independent laboratories attempting to create an Ewing sarcoma mouse modelFunctional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma.Bone- and cartilage-forming tumors and ewing sarcoma: an update with a gnathic emphasis.Melatonin Cytotoxicity Is Associated to Warburg Effect Inhibition in Ewing Sarcoma Cells.High-throughput small molecule screen identifies inhibitors of aberrant chromatin accessibility.Functional Genomic Screening Reveals Splicing of the EWS-FLI1 Fusion Transcript as a Vulnerability in Ewing Sarcoma.Targeting the EWS-ETS transcriptional program by BET bromodomain inhibition in Ewing sarcoma.BET bromodomain inhibitors suppress EWS-FLI1-dependent transcription and the IGF1 autocrine mechanism in Ewing sarcoma.CD99 triggering induces methuosis of Ewing sarcoma cells through IGF-1R/RAS/Rac1 signaling.EWS-FLI1 confers exquisite sensitivity to NAMPT inhibition in Ewing sarcoma cells.EWS/FLI1 Target Genes and Therapeutic Opportunities in Ewing Sarcoma.EWS-FLI1-mediated suppression of the RAS-antagonist Sprouty 1 (SPRY1) confers aggressiveness to Ewing sarcoma.Targeting the EWS-FLI1 transcription factor in Ewing sarcoma.Transgenic antigen-specific, HLA-A*02:01-allo-restricted cytotoxic T cells recognize tumor-associated target antigen STEAP1 with high specificity.EWS-FLI1 impairs aryl hydrocarbon receptor activation by blocking tryptophan breakdown via the kynurenine pathway.Inhibition of CHK1 sensitizes Ewing sarcoma cells to the ribonucleotide reductase inhibitor gemcitabine.A review of soft-tissue sarcomas: translation of biological advances into treatment measures.The Jumonji-domain histone demethylase inhibitor JIB-04 deregulates oncogenic programs and increases DNA damage in Ewing Sarcoma, resulting in impaired cell proliferation and survival, and reduced tumor growth
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P2860
Blocking the road, stopping the engine or killing the driver? Advances in targeting EWS/FLI-1 fusion in Ewing sarcoma as novel therapy.
description
2014 nî lūn-bûn
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2014年の論文
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年学术文章
@zh-my
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name
Blocking the road, stopping th ...... wing sarcoma as novel therapy.
@en
type
label
Blocking the road, stopping th ...... wing sarcoma as novel therapy.
@en
prefLabel
Blocking the road, stopping th ...... wing sarcoma as novel therapy.
@en
P2860
P1476
Blocking the road, stopping th ...... Ewing sarcoma as novel therapy
@en
P2093
Heinrich Kovar
P2860
P304
P356
10.1517/14728222.2014.947963
P407
P577
2014-08-27T00:00:00Z