Role of beta-adrenergic receptor signaling and desensitization in heart failure: new concepts and prospects for treatment.
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Myocardial adeno-associated virus serotype 6-betaARKct gene therapy improves cardiac function and normalizes the neurohormonal axis in chronic heart failuremiR-145 inhibits isoproterenol-induced cardiomyocyte hypertrophy by targeting the expression and localization of GATA6The expanding GRK interactome: Implications in cardiovascular disease and potential for therapeutic development.Modeling the effects of β1-adrenergic receptor blockers and polymorphisms on cardiac myocyte Ca2+ handling.Mechanisms of enhanced beta-adrenergic reserve from cardiac resynchronization therapy.Reduction of sympathetic activity via adrenal-targeted GRK2 gene deletion attenuates heart failure progression and improves cardiac function after myocardial infarctionElectrophysiological remodeling in heart failureLevel of G protein-coupled receptor kinase-2 determines myocardial ischemia/reperfusion injury via pro- and anti-apoptotic mechanisms.Differential regulation of EHD3 in human and mammalian heart failure.Decreased polycystin 2 expression alters calcium-contraction coupling and changes β-adrenergic signaling pathways.β-Adrenergic Receptor-Stimulated Cardiac Myocyte Apoptosis: Role of β1 Integrins.G protein coupled receptor kinases as therapeutic targets in cardiovascular disease.Cardiac GPCRs: GPCR signaling in healthy and failing hearts.Blockade of β-adrenoceptors restores the GRK2-mediated adrenal α(2) -adrenoceptor-catecholamine production axis in heart failureMechanisms of disease: detrimental adrenergic signaling in acute decompensated heart failure.Prognostic Value of Lymphocyte G Protein-Coupled Receptor Kinase-2 Protein Levels in Patients With Heart FailureAltered sarcoplasmic reticulum calcium cycling--targets for heart failure therapy.Metabolic therapy for the treatment of ischemic heart disease: reality and expectations.In vitro studies of early cardiac remodeling: impact on contraction and calcium handling.Decreased beta-adrenergic responsiveness following hypertrophy occurs only in cardiomyocytes that also re-express beta-myosin heavy chainTransgenic simulation of human heart failure-like L-type Ca2+-channels: implications for fibrosis and heart rate in mice.Cross-regulation between beta 1- and beta 3-adrenoceptors following chronic beta-adrenergic stimulation in neonatal rat cardiomyocytes.Functional relevance of biased signaling at the angiotensin II type 1 receptor.G protein-dependent and G protein-independent signaling pathways and their impact on cardiac function.G-protein coupled receptor resensitization-appreciating the balancing act of receptor function.A perspective on more effective GPCR-targeted drug discovery efforts.Apelin receptor: its responsiveness to stretch mechanisms and its potential for cardiovascular therapy.Phospholamban Inhibition by a Single Dose of Locked Nucleic Acid Antisense Oligonucleotide Improves Cardiac Contractility in Pressure Overload-Induced Systolic Dysfunction in Mice.The oxoglutarate receptor 1 (OXGR1) modulates pressure overload-induced cardiac hypertrophy in mice.Targeting GPCR-Gβγ-GRK2 signaling as a novel strategy for treating cardiorenal pathologies.AT-RvD1 combined with DEX is highly effective in treating TNF-α-mediated disruption of the salivary gland epitheliumCyclic AMP-dependent inotropic effects are differentially regulated by muscarinic G(i)-dependent constitutive inhibition of adenylyl cyclase in failing rat ventricleAdrenal GRK2 lowering is an underlying mechanism for the beneficial sympathetic effects of exercise training in heart failure.
P2860
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P2860
Role of beta-adrenergic receptor signaling and desensitization in heart failure: new concepts and prospects for treatment.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh
2006年學術文章
@zh-hant
name
Role of beta-adrenergic recept ...... s and prospects for treatment.
@ast
Role of beta-adrenergic recept ...... s and prospects for treatment.
@en
type
label
Role of beta-adrenergic recept ...... s and prospects for treatment.
@ast
Role of beta-adrenergic recept ...... s and prospects for treatment.
@en
prefLabel
Role of beta-adrenergic recept ...... s and prospects for treatment.
@ast
Role of beta-adrenergic recept ...... s and prospects for treatment.
@en
P2860
P356
P1476
Role of beta-adrenergic recept ...... s and prospects for treatment.
@en
P2093
Douglas G Tilley
Howard A Rockman
P2860
P304
P356
10.1586/14779072.4.3.417
P577
2006-05-01T00:00:00Z