The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure
about
CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophyRad GTPase deficiency leads to cardiac hypertrophyCa2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sitesRole of Ca2+/calmodulin-dependent protein kinase (CaMK) in excitation-contraction coupling in the heartNuclear calcium/calmodulin-dependent protein kinase IIdelta preferentially transmits signals to histone deacetylase 4 in cardiac cellsProtein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5Cyclophilin D controls mitochondrial pore-dependent Ca(2+) exchange, metabolic flexibility, and propensity for heart failure in mice.Recent advances in understanding cardiac contractility in health and diseaseRegulation of CaMKII signaling in cardiovascular diseaseSignaling effectors underlying pathologic growth and remodeling of the heartIon Channels in the HeartTranscriptional pathways and potential therapeutic targets in the regulation of Ncx1 expression in cardiac hypertrophy and failureL-type calcium channel targeting and local signalling in cardiac myocytesThe ryanodine receptor leak: how a tattered receptor plunges the failing heart into crisis'Ryanopathy': causes and manifestations of RyR2 dysfunction in heart failureCaMKII oxidative activation and the pathogenesis of cardiac diseaseCalmodulin-dependent protein kinase II: linking heart failure and arrhythmiasMechanisms of altered Ca²⁺ handling in heart failureNew therapeutic targets in cardiology: arrhythmias and Ca2+/calmodulin-dependent kinase II (CaMKII)CaMKIIdelta subtypes: localization and functionEarly cardiac hypertrophy in mice with impaired calmodulin regulation of cardiac muscle Ca release channel.miR-185 plays an anti-hypertrophic role in the heart via multiple targets in the calcium-signaling pathwaysAAV-mediated knock-down of HRC exacerbates transverse aorta constriction-induced heart failureThe δA isoform of calmodulin kinase II mediates pathological cardiac hypertrophy by interfering with the HDAC4-MEF2 signaling pathwayCaMKII determines mitochondrial stress responses in heartLocation matters: clarifying the concept of nuclear and cytosolic CaMKII subtypesCalmodulin mediates differential sensitivity of CaMKII and calcineurin to local Ca2+ in cardiac myocytesDifferential integration of Ca2+-calmodulin signal in intact ventricular myocytes at low and high affinity Ca2+-calmodulin targets.Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice.Voltage-Gated Sodium Channel Phosphorylation at Ser571 Regulates Late Current, Arrhythmia, and Cardiac Function In Vivo.Calmodulin kinase II initiates arrhythmogenicity during metabolic acidification in murine heartsRegulation of excitation-contraction coupling in mouse cardiac myocytes: integrative analysis with mathematical modellingOxidized calmodulin kinase II regulates conduction following myocardial infarction: a computational analysis.Dysregulated sarcoplasmic reticulum calcium release: potential pharmacological target in cardiac disease.Role of RyR2 phosphorylation in heart failure and arrhythmias: Controversies around ryanodine receptor phosphorylation in cardiac disease.CaMKII inhibition reduces isoproterenol-induced ischemia and arrhythmias in hypertrophic mice.Na+ channel regulation by Ca2+/calmodulin and Ca2+/calmodulin-dependent protein kinase II in guinea-pig ventricular myocytesCardioprotection by CaMKII-deltaB is mediated by phosphorylation of heat shock factor 1 and subsequent expression of inducible heat shock protein 70.Phospholamban ablation rescues sarcoplasmic reticulum Ca(2+) handling but exacerbates cardiac dysfunction in CaMKIIdelta(C) transgenic miceCardiac Protection of Valsartan on Juvenile Rats with Heart Failure by Inhibiting Activity of CaMKII via Attenuating Phosphorylation.
P2860
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P248
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P2860
The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure
description
2003 nî lūn-bûn
@nan
2003 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
The deltaC isoform of CaMKII i ...... rdiomyopathy and heart failure
@ast
The deltaC isoform of CaMKII i ...... rdiomyopathy and heart failure
@en
The deltaC isoform of CaMKII i ...... rdiomyopathy and heart failure
@en-gb
The deltaC isoform of CaMKII i ...... rdiomyopathy and heart failure
@nl
type
label
The deltaC isoform of CaMKII i ...... rdiomyopathy and heart failure
@ast
The deltaC isoform of CaMKII i ...... rdiomyopathy and heart failure
@en
The deltaC isoform of CaMKII i ...... rdiomyopathy and heart failure
@en-gb
The deltaC isoform of CaMKII i ...... rdiomyopathy and heart failure
@nl
prefLabel
The deltaC isoform of CaMKII i ...... rdiomyopathy and heart failure
@ast
The deltaC isoform of CaMKII i ...... rdiomyopathy and heart failure
@en
The deltaC isoform of CaMKII i ...... rdiomyopathy and heart failure
@en-gb
The deltaC isoform of CaMKII i ...... rdiomyopathy and heart failure
@nl
P2093
P921
P3181
P1433
P1476
The deltaC isoform of CaMKII i ...... rdiomyopathy and heart failure
@en
P2093
Joan Heller Brown
Lars S Maier
Nancy D Dalton
Shigeki Miyamoto
Tong Zhang
P304
P3181
P356
10.1161/01.RES.0000069686.31472.C5
P407
P577
2003-04-03T00:00:00Z