Isolation, sequence determination and expression in Escherichia coli of the isopenicillin N synthetase gene from Cephalosporium acremonium.
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Molecular regulation of beta-lactam biosynthesis in filamentous fungiCopurification and characterization of deacetoxycephalosporin C synthetase/hydroxylase from Cephalosporium acremoniumStearoyl-acyl carrier protein delta 9 desaturase from Ricinus communis is a diiron-oxo proteinCharacterization of the Cephalosporium acremonium pcbAB gene encoding alpha-aminoadipyl-cysteinyl-valine synthetase, a large multidomain peptide synthetase: linkage to the pcbC gene as a cluster of early cephalosporin biosynthetic genes and evidencePhotoaffinity labelling of isopenicillin N synthetase by laser-flash photolysisCloning and expression analysis of the pcbAB-pcbC beta-lactam genes in the marine fungus Kallichroma tethys.Cloning and characterization of the isopenicillin N synthase gene of Streptomyces griseus NRRL 3851 and studies of expression and complementation of the cephamycin pathway in Streptomyces clavuligerusBeta-lactam antibiotic biosynthetic genes have been conserved in clusters in prokaryotes and eukaryotes.Analysis of the role of cysteine residues in isopenicillin N synthetase activity by site-directed mutagenesis.Photoaffinity labelling of isopenicillin N synthetaseNon-heme Fe(IV)-oxo intermediates.Nonribosomal peptide synthetases involved in the production of medically relevant natural products.Organization of the biosynthesis genes for the peptide antibiotic gramicidin S.Cloning and characterization of beta-lactam biosynthetic genes.Gene cluster containing the genes for tyrocidine synthetases 1 and 2 from Bacillus brevis: evidence for an operon.Spectroscopic Evidence for the Two C-H-Cleaving Intermediates of Aspergillus nidulans Isopenicillin N Synthase.Epimerization and substrate gating by a TE domain in β-lactam antibiotic biosynthesis.Potential industrial use of cephalosporin biosynthetic enzymes and genes. An overview.Regulation and compartmentalization of β-lactam biosynthesis.Antibiotics--cloning of biosynthetic pathways.Molecular biology of penicillin and cephalosporin biosynthesis.Role of peroxisomes in the biosynthesis and secretion of β-lactams and other secondary metabolites.Origins of the β-lactam rings in natural products.Go it alone: four-electron oxidations by mononuclear non-heme iron enzymes.Dioxygen activation by nonheme iron enzymes with the 2-His-1-carboxylate facial triad that generate high-valent oxoiron oxidants.Peptide antibiotics, beta-lactams, and related compounds.Recombinant DNA in filamentous fungi: progress and prospects.Purification to homogeneity and characterization of acyl coenzyme A:6-aminopenicillanic acid acyltransferase of Penicillium chrysogenum.Efficient plasmid transformation of the beta-lactam producer Streptomyces clavuligerus.Exogenous methionine increases levels of mRNAs transcribed from pcbAB, pcbC, and cefEF genes, encoding enzymes of the cephalosporin biosynthetic pathway, in Acremonium chrysogenumCloning, characterization, and expression in Escherichia coli of the Streptomyces clavuligerus gene encoding deacetoxycephalosporin C synthetase.Beta-lactam biosynthesis in a gram-negative eubacterium: purification and characterization of isopenicillin N synthase from Flavobacterium sp. strain SC 12.154.Cloning and expression in Escherichia coli of isopenicillin N synthetase genes from Streptomyces lipmanii and Aspergillus nidulans.The cephamycin biosynthetic genes pcbAB, encoding a large multidomain peptide synthetase, and pcbC of Nocardia lactamdurans are clustered together in an organization different from the same genes in Acremonium chrysogenum and Penicillium chrysogenumThe Aspergillus nidulans npeA locus consists of three contiguous genes required for penicillin biosynthesisThe multifunctional peptide synthetase performing the first step of penicillin biosynthesis in Penicillium chrysogenum is a 421,073 dalton protein similar to Bacillus brevis peptide antibiotic synthetases.Engineering antibiotic producers to overcome the limitations of classical strain improvement programs.Modification of vertebrate and algal prolyl 4-hydroxylases and vertebrate lysyl hydroxylase by diethyl pyrocarbonate. Evidence for histidine residues in the catalytic site of 2-oxoglutarate-coupled dioxygenases.VTVH-MCD and DFT studies of thiolate bonding to [FeNO]7/[FeO2]8 complexes of isopenicillin N synthase: substrate determination of oxidase versus oxygenase activity in nonheme Fe enzymes.Factors affecting the isopenicillin N synthetase reaction.
P2860
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P2860
Isolation, sequence determination and expression in Escherichia coli of the isopenicillin N synthetase gene from Cephalosporium acremonium.
description
1985 nî lūn-bûn
@nan
1985年の論文
@ja
1985年学术文章
@wuu
1985年学术文章
@zh-cn
1985年学术文章
@zh-hans
1985年学术文章
@zh-my
1985年学术文章
@zh-sg
1985年學術文章
@yue
1985年學術文章
@zh
1985年學術文章
@zh-hant
name
Isolation, sequence determinat ...... rom Cephalosporium acremonium.
@ast
Isolation, sequence determinat ...... rom Cephalosporium acremonium.
@en
type
label
Isolation, sequence determinat ...... rom Cephalosporium acremonium.
@ast
Isolation, sequence determinat ...... rom Cephalosporium acremonium.
@en
prefLabel
Isolation, sequence determinat ...... rom Cephalosporium acremonium.
@ast
Isolation, sequence determinat ...... rom Cephalosporium acremonium.
@en
P2093
P356
P1433
P1476
Isolation, sequence determinat ...... rom Cephalosporium acremonium.
@en
P2093
Abraham EP
Baldwin JE
Belagaje R
Blankenship DT
Chapman JL
Queener SW
Skatrud PL
VanFrank RM
P2860
P2888
P304
P356
10.1038/318191A0
P407
P577
1985-11-01T00:00:00Z
P6179
1005107649