Mitochondrial deafness alleles confer misreading of the genetic code - Wikidata - awgldk - TriplyDB

Mitochondrial deafness alleles confer misreading of the genetic code

Mitochondrial deafness alleles confer misreading of the genetic code

http://www.wikidata.org/entity/Q36491293

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Study of streptomycin-induced ototoxicity: protocol for a longitudinal study.Dissociation of antibacterial activity and aminoglycoside ototoxicity in the 4-monosubstituted 2-deoxystreptamine apramycin 4′-O-substitutions determine selectivity of aminoglycoside antibiotics Overexpression of the mitochondrial methyltransferase TFB1M in the mouse does not impact mitoribosomal methylation status or hearing.The mitochondrion: a perpetrator of acquired hearing loss.Mitochondrial stress engages E2F1 apoptotic signaling to cause deafness Gentamicin rapidly inhibits mitochondrial metabolism in high-frequency cochlear outer hair cells.A six-generation Chinese family in haplogroup B4C1C exhibits high penetrance of 1555A > G-induced hearing Loss Genetic analysis of interactions with eukaryotic rRNA identify the mitoribosome as target in aminoglycoside ototoxicity.The role of the mitochondrial ribosome in human disease: searching for mutations in 12S mitochondrial rRNA with high disruptive potential.Development of novel aminoglycoside (NB54) with reduced toxicity and enhanced suppression of disease-causing premature stop mutations New trends in aminoglycosides use.Identification and evaluation of improved 4'-O-(alkyl) 4,5-disubstituted 2-deoxystreptamines as next-generation aminoglycoside antibiotics.Increased selectivity toward cytoplasmic versus mitochondrial ribosome confers improved efficiency of synthetic aminoglycosides in fixing damaged genes: a strategy for treatment of genetic diseases caused by nonsense mutations Molecular basis for the selectivity of antituberculosis compounds capreomycin and viomycin.Hearing in 44-45 year olds with m.1555A>G, a genetic mutation predisposing to aminoglycoside-induced deafness: a population based cohort study.A meta-analysis and systematic review of the prevalence of mitochondrially encoded 12S RNA in the general population: Is there a role for screening neonates requiring aminoglycosides?Evidence That Antibiotics Bind to Human Mitochondrial Ribosomal RNA Has Implications for Aminoglycoside Toxicity.Effects of airborne pollutants on mitochondrial DNA methylation.A rapid method for detection of five known mutations associated with aminoglycoside-induced deafness.Mitochondrial m.1584A 12S m62A rRNA methylation in families with m.1555A>G associated hearing loss.Phenotypic expression of maternally inherited deafness is affected by RNA modification and cytoplasmic ribosomal proteins.Designer aminoglycosides that selectively inhibit cytoplasmic rather than mitochondrial ribosomes show decreased ototoxicity: a strategy for the treatment of genetic diseases.Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux Elements of ribosomal drug resistance and specificity.Phylogenetic sequence variations in bacterial rRNA affect species-specific susceptibility to drugs targeting protein synthesis.Importance of the 6'-hydroxy group and its configuration for apramycin activity.N6', N6''', and O4' Modifications to Neomycin Affect Ribosomal Selectivity without Compromising Antibacterial Activity.Mutant A1555G mitochondrial 12S rRNA and aminoglycoside susceptibility.PharmGKB summary: very important pharmacogene information for MT-RNR1.Towards the Prevention of Aminoglycoside-Related Hearing Loss.Aminoglycoside-Induced Cochleotoxicity: A Review.Structure-Based Design and Synthesis of Apramycin-Paromomycin Analogues: Importance of the Configuration at the 6'-Position and Differences between the 6'-Amino and Hydroxy Series.Mutant MRPS5 affects mitoribosomal accuracy and confers stress-related behavioral alterations

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P2860

Mitochondrial deafness alleles confer misreading of the genetic code

http://www.wikidata.org/entity/Q36491293

description

2008 nî lūn-bûn

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2008年の論文

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

@zh-my

2008年学术文章

@zh-sg

2008年學術文章

@yue

2008年學術文章

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2008年學術文章

@zh-hant

name

Mitochondrial deafness alleles confer misreading of the genetic code

@ast

Mitochondrial deafness alleles confer misreading of the genetic code

@en

type

label

Mitochondrial deafness alleles confer misreading of the genetic code

@ast

Mitochondrial deafness alleles confer misreading of the genetic code

@en

prefLabel

Mitochondrial deafness alleles confer misreading of the genetic code

@ast

Mitochondrial deafness alleles confer misreading of the genetic code

@en

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PNAS.0707265105

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Mitochondrial deafness alleles confer misreading of the genetic code

@en

P2093

Christian M Bruell

http://www.w3.org/2001/XMLSchema#string

Dmitry Shcherbakov

http://www.w3.org/2001/XMLSchema#string

Sarath K Kalapala

http://www.w3.org/2001/XMLSchema#string

Subramanian Akshay

http://www.w3.org/2001/XMLSchema#string

Sven N Hobbie

http://www.w3.org/2001/XMLSchema#string

P2860

Mutation in TRMU related to transfer RNA modification modulates the phenotypic expression of the deafness-associated mitochondrial 12S ribosomal RNA mutations

Functional characterization of the mitochondrial 12S rRNA C1494T mutation associated with aminoglycoside-induced and non-syndromic hearing loss

Two conformational states in the crystal structure of the Homo sapiens cytoplasmic ribosomal decoding A site.

Structure of functionally activated small ribosomal subunit at 3.3 angstroms resolution

Structure of the 30S ribosomal subunit

Recognition of cognate transfer RNA by the 30S ribosomal subunit

Selection of tRNA by the ribosome requires a transition from an open to a closed form

MTO1 codes for a mitochondrial protein required for respiration in paromomycin-resistant mutants of Saccharomyces cerevisiae.

Human mitochondrial transcription factor B1 methylates ribosomal RNA at a conserved stem-loop

Isolation and characterization of the putative nuclear modifier gene MTO1 involved in the pathogenesis of deafness-associated mitochondrial 12 S rRNA A1555G mutation

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3244-3249

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scholarly article

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10.1073/PNAS.0707265105

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9

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105

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Erik C Böttger

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2008-02-28T00:00:00Z

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5543353

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18308926

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2265171

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