The glutamate transporter subtypes EAAT4 and EAATs 1-3 transport glutamate with dramatically different kinetics and voltage dependence but share a common uptake mechanism.
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The glutamate-activated anion conductance in excitatory amino acid transporters is gated independently by the individual subunitsMechanisms of glutamate transportFunctional properties of the retinal glutamate transporters GLT-1c and EAAT5Targeted deletion of betaIII spectrin impairs synaptogenesis and generates ataxic and seizure phenotypes.Glutamate transporters EAAT4 and EAAT5 are expressed in vestibular hair cells and calyx endings.Glial and Neuronal Glutamate Transporters Differ in the Na+ Requirements for Activation of the Substrate-Independent Anion ConductanceMechanism of cation binding to the glutamate transporter EAAC1 probed with mutation of the conserved amino acid residue Thr101.The discovery of slowness: low-capacity transport and slow anion channel gating by the glutamate transporter EAAT5.Glutamate as a neurotransmitter in the healthy brainIdentification of the third Na+ site and the sequence of extracellular binding events in the glutamate transporter.Turnover rate of the gamma-aminobutyric acid transporter GAT1.Hetero-oligomerization of neuronal glutamate transportersThe role of glutamate transporters in neurodegenerative diseases and potential opportunities for intervention.A Mutation in Transmembrane Domain 7 (TM7) of Excitatory Amino Acid Transporters Disrupts the Substrate-dependent Gating of the Intrinsic Anion Conductance and Drives the Channel into a Constitutively Open State.Two conformational changes are associated with glutamate translocation by the glutamate transporter EAAC1.Electrogenic Steps Associated with Substrate Binding to the Neuronal Glutamate Transporter EAAC1Induced fit substrate binding to an archeal glutamate transporter homologueGlutamate forward and reverse transport: from molecular mechanism to transporter-mediated release after ischemia.The neuromediator glutamate, through specific substrate interactions, enhances mitochondrial ATP production and reactive oxygen species generation in nonsynaptic brain mitochondria.Mutating a conserved proline residue within the trimerization domain modifies Na+ binding to excitatory amino acid transporters and associated conformational changes.Glutamate transporter EAAT2: regulation, function, and potential as a therapeutic target for neurological and psychiatric disease.Molecular physiology of EAAT anion channels.Astroglial glutamate transporters coordinate excitatory signaling and brain energetics.The Glutamate-Glutamine Cycle in Epilepsy.Substrate-dependent gating of anion channels associated with excitatory amino acid transporter 4Regulation of glial glutamate transporters by C-terminal domains.Currents in response to rapid concentration jumps of amphetamine uncover novel aspects of human dopamine transporter function.Neuronal glutamate transporters vary in substrate transport rate but not in unitary anion channel conductance.Functional contributions of glutamate transporters at the parallel fibre to Purkinje neuron synapse-relevance for the progression of cerebellar ataxia.Neutralizing aspartate 83 modifies substrate translocation of excitatory amino acid transporter 3 (EAAT3) glutamate transporters.A conserved aspartate determines pore properties of anion channels associated with excitatory amino acid transporter 4 (EAAT4).Novel role of the nociceptin system as a regulator of glutamate transporter expression in developing astrocytes.Kinetic mechanism of coupled binding in sodium-aspartate symporter GltPh
P2860
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P2860
The glutamate transporter subtypes EAAT4 and EAATs 1-3 transport glutamate with dramatically different kinetics and voltage dependence but share a common uptake mechanism.
description
2005 nî lūn-bûn
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2005年の論文
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2005年学术文章
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2005年学术文章
@zh-cn
2005年学术文章
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2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
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name
The glutamate transporter subt ...... are a common uptake mechanism.
@ast
The glutamate transporter subt ...... are a common uptake mechanism.
@en
type
label
The glutamate transporter subt ...... are a common uptake mechanism.
@ast
The glutamate transporter subt ...... are a common uptake mechanism.
@en
prefLabel
The glutamate transporter subt ...... are a common uptake mechanism.
@ast
The glutamate transporter subt ...... are a common uptake mechanism.
@en
P2093
P2860
P356
P1476
The glutamate transporter subt ...... are a common uptake mechanism.
@en
P2093
Carsten Mim
Christof Grewer
Poonam Balani
Thomas Rauen
P2860
P304
P356
10.1085/JGP.200509365
P577
2005-12-01T00:00:00Z