The lysosomal-mitochondrial axis theory of postmitotic aging and cell death.
about
Chloroquine treatment of ARPE-19 cells leads to lysosome dilation and intracellular lipid accumulation: possible implications of lysosomal dysfunction in macular degenerationTowards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examplesThe proteome of lysosomesMitochondrial adaptations evoked with exercise are associated with a reduction in age-induced testicular atrophy in Fischer-344 ratsAmino acid homeostasis and chronological longevity in Saccharomyces cerevisiaeThe role of TRPMLs in endolysosomal trafficking and functionAfter the banquet: mitochondrial biogenesis, mitophagy, and cell survivalOxidative stress and the homeodynamics of iron metabolismDeletion of the huntingtin polyglutamine stretch enhances neuronal autophagy and longevity in mice.Cardiomyocyte death in doxorubicin-induced cardiotoxicityGangliosides induce autophagic cell death in astrocytes.The age related markers lipofuscin and apoptosis show different genetic architecture by QTL mapping in short-lived Nothobranchius fishPompe disease: from pathophysiology to therapy and back againAutophagy in health and disease. 5. Mitophagy as a way of lifeOxidative stress and autophagy in the regulation of lysosome-dependent neuron death.Increased superoxide in vivo accelerates age-associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degenerationSuppression of mTORC1 activation in acid-α-glucosidase-deficient cells and mice is ameliorated by leucine supplementation.Levels of aqueous humor trace elements in patients with non-exsudative age-related macular degeneration: a case-control studyIntralysosomal iron induces lysosomal membrane permeabilization and cathepsin D-mediated cell death in trabecular meshwork cells exposed to oxidative stress.Dysregulation of mitochondrial quality control processes contribute to sarcopenia in a mouse model of premature aging.A53T human α-synuclein overexpression in transgenic mice induces pervasive mitochondria macroautophagy defects preceding dopamine neuron degenerationPINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis.Iron alters cell survival in a mitochondria-dependent pathway in ovarian cancer cells.Autophagy inhibitor LRPPRC suppresses mitophagy through interaction with mitophagy initiator Parkin.Oxidative stress induces overgrowth of the Drosophila neuromuscular junction.New roles of glycosaminoglycans in α-synuclein aggregation in a cellular model of Parkinson disease.Species-Related Differences in the Proteome of Rat and Human Pancreatic Beta Cells.Cardiac aging: from molecular mechanisms to significance in human health and diseaseAtorvastatin inhibits the apoptosis of human umbilical vein endothelial cells induced by angiotensin II via the lysosomal-mitochondrial axis.Manipulation of in vivo iron levels can alter resistance to oxidative stress without affecting ageing in the nematode C. elegansEffects of intravitreal injection of netrin-1 in retinal neovascularization of streptozotocin-induced diabetic rats.BECLIN 1-VPS34 COMPLEX ARCHITECTURE: UNDERSTANDING THE NUTS AND BOLTS OF THERAPEUTIC TARGETS.Aging results in increased autophagy of mitochondria and protein nitration in rat hepatocytes following heat stress.Mitochondrial translocation of alpha-synuclein is promoted by intracellular acidification.Glucose restriction induces cell death in parental but not in homeodomain-interacting protein kinase 2-depleted RKO colon cancer cells: molecular mechanisms and implications for tumor therapyAkt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents.Mitochondrial dysfunction and oxidative stress in patients with chronic kidney disease.The Octyl Ester of Ginsenoside Rh2 Induces Lysosomal Membrane Permeabilization via Bax Translocation.Autophagy and leucine promote chronological longevity and respiration proficiency during calorie restriction in yeast.Lysosomes in iron metabolism, ageing and apoptosis.
P2860
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P2860
The lysosomal-mitochondrial axis theory of postmitotic aging and cell death.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh
2006年學術文章
@zh-hant
name
The lysosomal-mitochondrial axis theory of postmitotic aging and cell death.
@ast
The lysosomal-mitochondrial axis theory of postmitotic aging and cell death.
@en
type
label
The lysosomal-mitochondrial axis theory of postmitotic aging and cell death.
@ast
The lysosomal-mitochondrial axis theory of postmitotic aging and cell death.
@en
prefLabel
The lysosomal-mitochondrial axis theory of postmitotic aging and cell death.
@ast
The lysosomal-mitochondrial axis theory of postmitotic aging and cell death.
@en
P2093
P1476
The lysosomal-mitochondrial axis theory of postmitotic aging and cell death.
@en
P2093
Alexei Terman
Bertil Gustafsson
Ulf T Brunk
P356
10.1016/J.CBI.2006.04.013
P577
2006-05-01T00:00:00Z