Human SH2B1 mutations are associated with maladaptive behaviors and obesity. - Wikidata - awgldk - TriplyDB

Human SH2B1 mutations are associated with maladaptive behaviors and obesity.

Human SH2B1 mutations are associated with maladaptive behaviors and obesity.

http://www.wikidata.org/entity/Q36497996

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Obesity genetics in mouse and human: back and forth, and back again Human β-cell proliferation and intracellular signaling: part 3 Brain regulation of energy balance and body weight.SH2B1 and IRSp53 proteins promote the formation of dendrites and dendritic branches SH2B1 regulation of energy balance, body weight, and glucose metabolism.Functional characterization of obesity-associated variants involving the α and β isoforms of human SH2B1 Truncating Homozygous Mutation of Carboxypeptidase E (CPE) in a Morbidly Obese Female with Type 2 Diabetes Mellitus, Intellectual Disability and Hypogonadotrophic Hypogonadism.Mutation screen in the GWAS derived obesity gene SH2B1 including functional analyses of detected variants.Screening for coding variants in FTO and SH2B1 genes in Chinese patients with obesity.Gene-environment interactions controlling energy and glucose homeostasis and the developmental origins of obesity New function of the adaptor protein SH2B1 in brain-derived neurotrophic factor-induced neurite outgrowth Hepatic SH2B1 and SH2B2 regulate liver lipid metabolism and VLDL secretion in mice Fine Mapping of a GWAS-Derived Obesity Candidate Region on Chromosome 16p11.2.Pediatric obesity. An introduction A compendium of human genes regulating feeding behavior and body weight, its functional characterization and identification of GWAS genes involved in brain-specific PPI network Phosphorylation of the adaptor protein SH2B1β regulates its ability to enhance growth hormone-dependent macrophage motility JAK-STAT and feeding.Glucagon-like peptide 1 in the pathophysiology and pharmacotherapy of clinical obesity.SH2B1 in β-cells regulates glucose metabolism by promoting β-cell survival and islet expansion.SH2B1 in β-cells promotes insulin expression and glucose metabolism in mice.Genetic, molecular and physiological mechanisms involved in human obesity: Society for Endocrinology Medal Lecture 2012.A survival Kit for pancreatic beta cells: stem cell factor and c-Kit receptor tyrosine kinase.Discussing the putative role of obesity-associated genes in the etiopathogenesis of eating disorders.Making sense of metabolic obesity and hedonic obesity.A systematic review of genetic syndromes with obesity.PTPRJ Inhibits Leptin Signaling, and Induction of PTPRJ in the Hypothalamus Is a Cause of the Development of Leptin Resistance.SH2B1 is critical for the regulation of cardiac remodelling in response to pressure overload.Chromosomal contacts connect loci associated with autism, BMI and head circumference phenotypes.The Immune Signaling Adaptor LAT Contributes to the Neuroanatomical Phenotype of 16p11.2 BP2-BP3 CNVs.Phosphorylation of the Unique C-terminal Tail of the Alpha Isoform of the Scaffold Protein SH2B1 Controls the Ability of SH2B1alpha to Enhance Nerve Growth Factor Function.Neural deletion of Sh2b1 results in brain growth retardation and reactive aggression.On the origin of obesity: identifying the biological, environmental and cultural drivers of genetic risk among human populations.The Prader-Willi syndrome proteins MAGEL2 and necdin regulate leptin receptor cell surface abundance through ubiquitination pathways.Chromosomal microarray analysis in the genetic evaluation of 279 patients with syndromic obesity.Leptin Function and Regulation.Discordant phenotypes in monozygotic twins with 16p11.2 microdeletions including the SH2B1 gene.The Effect of SH2B1 Variants on Expression of Leptin- and Insulin-Induced Pathways in Murine Hypothalamus.A nonsense loss-of-function mutation in PCSK1 contributes to dominantly inherited human obesity

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P2860

Human SH2B1 mutations are associated with maladaptive behaviors and obesity.

http://www.wikidata.org/entity/Q36497996

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2012 nî lūn-bûn

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2012年の論文

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年學術文章

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2012年學術文章

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2012年學術文章

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name

Human SH2B1 mutations are associated with maladaptive behaviors and obesity.

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Human SH2B1 mutations are associated with maladaptive behaviors and obesity.

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type

label

Human SH2B1 mutations are associated with maladaptive behaviors and obesity.

@ast

Human SH2B1 mutations are associated with maladaptive behaviors and obesity.

@en

prefLabel

Human SH2B1 mutations are associated with maladaptive behaviors and obesity.

@ast

Human SH2B1 mutations are associated with maladaptive behaviors and obesity.

@en

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Journal of Clinical Investigation

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Human SH2B1 mutations are associated with maladaptive behaviors and obesity.

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Anne Dale

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Christin Carter-Su

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Elana Henning

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Hsiao-Wen Su

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Joel M Cline

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Julia M Keogh

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Lawrence S Argetsinger

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Liangyou Rui

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Michael E Doche

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Sadia Saeed

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Positional cloning of the mouse obese gene and its human homologue

Interaction of SH2-Bbeta with RET is involved in signaling of GDNF-induced neurite outgrowth

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

Large, rare chromosomal deletions associated with severe early-onset obesity

Identification of SH2-Bbeta as a substrate of the tyrosine kinase JAK2 involved in growth hormone signaling

Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene

SH2-Bbeta is a Rac-binding protein that regulates cell motility

Identification and characterization of novel substrates of Trk receptors in developing neurons

Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta

Four PSM/SH2-B alternative splice variants and their differential roles in mitogenesis.

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4732-4736

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scholarly article

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10.1172/JCI62696

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12

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122

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Elena G. Bochukova

Stephen O'Rahilly

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2012-11-19T00:00:00Z

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233537543

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23160192

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