BCL-2 in the crosshairs: tipping the balance of life and death.
about
The hepatitis C virus core protein contains a BH3 domain that regulates apoptosis through specific interaction with human Mcl-1Disruption of Bcl-2 and Bcl-xL by viral proteins as a possible cause of cancerCancer across the tree of life: cooperation and cheating in multicellularityBAX activation is initiated at a novel interaction siteRegulation of mitochondrial ceramide distribution by members of the BCL-2 familyDownregulation of B-cell lymphoma/leukemia-2 by overexpressed microRNA 34a enhanced titanium dioxide nanoparticle-induced autophagy in BEAS-2B cellsMitochondrial redox metabolism in trypanosomatids is independent of tryparedoxin activityDOT1L inhibition sensitizes MLL-rearranged AML to chemotherapyGLTSCR2/PICT-1, a putative tumor suppressor gene product, induces the nucleolar targeting of the Kaposi's sarcoma-associated herpesvirus KS-Bcl-2 protein.Cryptotanshinone induces cell cycle arrest and apoptosis through the JAK2/STAT3 and PI3K/Akt/NFκB pathways in cholangiocarcinoma cells.Heterocyclic alpha-helix mimetics for targeting protein-protein interactionsBcl-XL-templated assembly of its own protein-protein interaction modulator from fragments decorated with thio acids and sulfonyl azides.Reconstitution and engineering of apoptotic protein interactions on the bacterial cell surface.Defective autophagy is associated with neuronal injury in a mouse model of multiple sclerosisArtesunate inhibits growth and induces apoptosis in human osteosarcoma HOS cell line in vitro and in vivoDownregulation of autophagy by Bcl-2 promotes MCF7 breast cancer cell growth independent of its inhibition of apoptosis.The pro-survival role of autophagy depends on Bcl-2 under nutrition stress conditionsCurcumin induces apoptosis in gallbladder carcinoma cell line GBC-SD cells.Samsoeum, a traditional herbal medicine, elicits apoptotic and autophagic cell death by inhibiting Akt/mTOR and activating the JNK pathway in cancer cellsSmall molecule inhibitors of bcl-2 family proteins for pancreatic cancer therapyTriptolide induces s phase arrest and apoptosis in gallbladder cancer cells.Multiple BH3 mimetics antagonize antiapoptotic MCL1 protein by inducing the endoplasmic reticulum stress response and up-regulating BH3-only protein NOXA.Inhibition of eEF-2 kinase sensitizes human glioma cells to TRAIL and down-regulates Bcl-xL expressionInfluence of levosimendan postconditioning on apoptosis of rat lung cells in a model of ischemia-reperfusion injury.Identification of the Essential Role of Viral Bcl-2 for Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication.Viral Bcl-2 Encoded by the Kaposi's Sarcoma-Associated Herpesvirus Is Vital for Virus Reactivation.A comparison of the biological effects of 125I seeds continuous low-dose-rate radiation and 60Co high-dose-rate gamma radiation on non-small cell lung cancer cells.Key role for Bak activation and Bak-Bax interaction in the apoptotic response to vinblastineOleanolic acid induces mitochondrial-dependent apoptosis and G0/G1 phase arrest in gallbladder cancer cells.Interaction surface and topology of Get3-Get4-Get5 protein complex, involved in targeting tail-anchored proteins to endoplasmic reticulum.Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells.Select Bcl-2 antagonism restores chemotherapy sensitivity in high-risk neuroblastoma.Metabolic stress in autophagy and cell death pathwaysTime depended Bcl-2 inhibition might be useful for a targeted drug therapy.Molecular control of bacterial death and lysisObatoclax interacts synergistically with the irreversible proteasome inhibitor carfilzomib in GC- and ABC-DLBCL cells in vitro and in vivoProapoptotic Role of Potassium Ions in Liver CellsBH3 response profiles from neuroblastoma mitochondria predict activity of small molecule Bcl-2 family antagonists.Physiological functions of Atg6/Beclin 1: a unique autophagy-related protein.Autophagy provides nutrients but can lead to Chop-dependent induction of Bim to sensitize growth factor-deprived cells to apoptosis.
P2860
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P2860
BCL-2 in the crosshairs: tipping the balance of life and death.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
BCL-2 in the crosshairs: tipping the balance of life and death.
@ast
BCL-2 in the crosshairs: tipping the balance of life and death.
@en
type
label
BCL-2 in the crosshairs: tipping the balance of life and death.
@ast
BCL-2 in the crosshairs: tipping the balance of life and death.
@en
prefLabel
BCL-2 in the crosshairs: tipping the balance of life and death.
@ast
BCL-2 in the crosshairs: tipping the balance of life and death.
@en
P356
P1476
BCL-2 in the crosshairs: tipping the balance of life and death.
@en
P2093
Walensky LD
P2888
P304
P356
10.1038/SJ.CDD.4401992
P577
2006-06-09T00:00:00Z