BH3 response profiles from neuroblastoma mitochondria predict activity of small molecule Bcl-2 family antagonists. - Wikidata - awgldk - TriplyDB

BH3 response profiles from neuroblastoma mitochondria predict activity of small molecule Bcl-2 family antagonists.

BH3 response profiles from neuroblastoma mitochondria predict activity of small molecule Bcl-2 family antagonists.

http://www.wikidata.org/entity/Q36948615

about

Use of human cancer cell lines mitochondria to explore the mechanisms of BH3 peptides and ABT-737-induced mitochondrial membrane permeabilization MiR-133b regulates bladder cancer cell proliferation and apoptosis by targeting Bcl-w and Akt1.The stress protein BAG3 stabilizes Mcl-1 protein and promotes survival of cancer cells and resistance to antagonist ABT-737 Miniature short hairpin RNA screens to characterize antiproliferative drugs Distribution of Bim determines Mcl-1 dependence or codependence with Bcl-xL/Bcl-2 in Mcl-1-expressing myeloma cells.Select Bcl-2 antagonism restores chemotherapy sensitivity in high-risk neuroblastoma.The ALK(F1174L) mutation potentiates the oncogenic activity of MYCN in neuroblastoma How to target apoptosis signaling pathways for the treatment of pediatric cancers Myeloid cell leukemia-1 is an important apoptotic survival factor in triple-negative breast cancer.Multiple components of the spliceosome regulate Mcl1 activity in neuroblastoma.Apoptotic cell death in neuroblastoma.Small-molecule inhibitors reveal a new function for Bcl-2 as a proangiogenic signaling molecule.Nutrient availability links mitochondria, apoptosis, and obesity.EGFR signaling defines Mcl⁻1 survival dependency in neuroblastoma.Mcl-1 and FBW7 control a dominant survival pathway underlying HDAC and Bcl-2 inhibitor synergy in squamous cell carcinoma.RNA interference screening identifies a novel role for autocrine fibroblast growth factor signaling in neuroblastoma chemoresistance.Mitochondrial Bcl-2 family dynamics define therapy response and resistance in neuroblastoma The novel Bcl-2 inhibitor ABT-737 is more effective in hypoxia and is able to reverse hypoxia-induced drug resistance in neuroblastoma cells.The Bcl-2/Bcl-XL inhibitor ABT-737 promotes death of retinoblastoma cancer cells.Targeting Bcl-2-mediated cell death as a novel therapy in pancreatic cancer.Dual targeting of MDM2 and BCL2 as a therapeutic strategy in neuroblastoma.Understanding sensitivity to BH3 mimetics: ABT-737 as a case study to foresee the complexities of personalized medicine.Preferential targeting of cancer stem cells in the radiosensitizing effect of ABT-737 on HNSCC.MicroRNA-193b-3p represses neuroblastoma cell growth via downregulation of Cyclin D1, MCL-1 and MYCN.

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P2860

BH3 response profiles from neuroblastoma mitochondria predict activity of small molecule Bcl-2 family antagonists.

http://www.wikidata.org/entity/Q36948615

description

2009 nî lūn-bûn

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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2009年论文

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2009年论文

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name

BH3 response profiles from neu ...... cule Bcl-2 family antagonists.

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type

label

BH3 response profiles from neu ...... cule Bcl-2 family antagonists.

@en

prefLabel

BH3 response profiles from neu ...... cule Bcl-2 family antagonists.

@en

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Cell Death & Differentiation

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BH3 response profiles from neu ...... cule Bcl-2 family antagonists.

@en

P2093

A Bhumbla

http://www.w3.org/2001/XMLSchema#string

B J Lestini

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H Zhao

http://www.w3.org/2001/XMLSchema#string

K C Goldsmith

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L Ip

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M D Hogarty

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M Gross

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X Liu

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X Zhang

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P2860

Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins.

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

BID: a novel BH3 domain-only death agonist

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents

Identification of ALK as a major familial neuroblastoma predisposition gene

BAX activation is initiated at a novel interaction site

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872-882

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scholarly article

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10.1038/CDD.2009.171

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5

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17

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38070990

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19893570

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3690273

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