To step or not to step? How biochemistry and mechanics influence processivity in Kinesin and Eg5.
about
Targeting of MAPK-associated molecules identifies SON as a prime target to attenuate the proliferation and tumorigenicity of pancreatic cancer cellsKinesin-5: cross-bridging mechanism to targeted clinical therapyProgrammable Potentials: Approximate N-body potentials from coarse-level logic.Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin 1Anaphase BParkin regulates Eg5 expression by Hsp70 ubiquitination-dependent inactivation of c-Jun NH2-terminal kinaseDimethylenastron suppresses human pancreatic cancer cell migration and invasion in vitro via allosteric inhibition of mitotic kinesin Eg5.Structure and dynamics of the kinesin-microtubule interaction revealed by fluorescence polarization microscopy.Opposite-polarity motors activate one another to trigger cargo transport in live cellsThe mechanical properties of kinesin-1: a holistic approach.Kinesin-1 tail autoregulation and microtubule-binding regions function in saltatory transport but not ooplasmic streaming.Specific interaction of KIF11 with ZBP1 regulates the transport of β-actin mRNA and cell motilityA universal pathway for kinesin stepping.Impact of kinesin Eg5 inhibition by 3,4-dihydropyrimidin-2(1H)-one derivatives on various breast cancer cell features.Load-dependent mechanism of nonmuscle myosin 2.Force-dependent detachment of kinesin-2 biases track switching at cytoskeletal filament intersections.Microtubule capture by mitotic kinesin centromere protein E (CENP-E).Single-molecule biophysics: at the interface of biology, physics and chemistryGetting in sync with dimeric Eg5. Initiation and regulation of the processive run.Modular aspects of kinesin force generation machineryUbiquitin ligase RNF20/40 facilitates spindle assembly and promotes breast carcinogenesis through stabilizing motor protein Eg5.Energetics of kinesin-1 stepping mechanism.Walking the walk: how kinesin and dynein coordinate their steps.The ATPase cycle of the mitotic motor CENP-E.Structures of kinesin motor proteins.Mitotic functions of kinesin-5.The Kinesin-5 Chemomechanical Cycle Is Dominated by a Two-heads-bound State.Intramolecular strain coordinates kinesin stepping behavior along microtubules.Modulation of Eg5 activity contributes to mitotic spindle checkpoint activation and Tat-mediated apoptosis in CD4-positive T-lymphocytes.High Eg5 expression predicts poor prognosis in breast cancer.Mechanical coupling of microtubule-dependent motor teams during peroxisome transport in Drosophila S2 cells.Altered chemomechanical coupling causes impaired motility of the kinesin-4 motors KIF27 and KIF7.Direct observation of intermediate states during the stepping motion of kinesin-1.KIF15 nanomechanics and kinesin inhibitors, with implications for cancer chemotherapeutics.Ectopic expression of the microtubule-dependent motor protein Eg5 promotes pancreatic tumourigenesisFingerprinting differential active site constraints of ATPases
P2860
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P2860
To step or not to step? How biochemistry and mechanics influence processivity in Kinesin and Eg5.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
To step or not to step? How bi ...... ocessivity in Kinesin and Eg5.
@ast
To step or not to step? How bi ...... ocessivity in Kinesin and Eg5.
@en
type
label
To step or not to step? How bi ...... ocessivity in Kinesin and Eg5.
@ast
To step or not to step? How bi ...... ocessivity in Kinesin and Eg5.
@en
prefLabel
To step or not to step? How bi ...... ocessivity in Kinesin and Eg5.
@ast
To step or not to step? How bi ...... ocessivity in Kinesin and Eg5.
@en
P2860
P1476
To step or not to step? How bi ...... rocessivity in Kinesin and Eg5
@en
P2093
Susan P Gilbert
P2860
P356
10.1016/J.CEB.2006.12.011
P577
2006-12-26T00:00:00Z