An improved small-molecule inhibitor of FtsZ with superior in vitro potency, drug-like properties, and in vivo efficacy.
about
Harnessing single cell sorting to identify cell division genes and regulators in bacteriaScreening and Development of New Inhibitors of FtsZ from M. TuberculosisA novel quinoline derivative that inhibits mycobacterial FtsZ.BT-benzo-29 inhibits bacterial cell proliferation by perturbing FtsZ assembly.In Vivo Pharmacodynamic Evaluation of an FtsZ Inhibitor, TXA-709, and Its Active Metabolite, TXA-707, in a Murine Neutropenic Thigh Infection Model.An FtsZ-targeting prodrug with oral antistaphylococcal efficacy in vivoEffects of rhodomyrtone on Gram-positive bacterial tubulin homologue FtsZ.Identification of agents targeting FtsZ assembly.RfiA, a novel PAP2 domain-containing polytopic membrane protein that confers resistance to the FtsZ inhibitor PC190723.2,6-Difluorobenzamide Inhibitors of Bacterial Cell Division Protein FtsZ: Design, Synthesis, and Structure-Activity Relationships.A benzamide-dependent ftsZ mutant reveals residues crucial for Z-ring assembly.Enterococcal and streptococcal resistance to PC190723 and related compounds: molecular insights from a FtsZ mutational analysis.Cytological Profile of Antibacterial FtsZ Inhibitors and Synthetic Peptide MciZ.Mutation at G103 of MtbFtsZ Altered their Sensitivity to CoumarinsStructural Flexibility of an Inhibitor Overcomes Drug Resistance Mutations in Staphylococcus aureus FtsZ.Comparative proteomics analysis of Neisseria gonorrhoeae strains in response to extended-spectrum cephalosporins.A combined CoMFA and CoMSIA 3D-QSAR study of benzamide type antibacterial inhibitors of the FtsZ protein in drug-resistant Staphylococcus aureus.Efficient Synthesis of Amine-Linked 2,4,6-Trisubstituted Pyrimidines as a New Class of Bacterial FtsZ Inhibitors.
P2860
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P2860
An improved small-molecule inhibitor of FtsZ with superior in vitro potency, drug-like properties, and in vivo efficacy.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
An improved small-molecule inh ...... perties, and in vivo efficacy.
@ast
An improved small-molecule inh ...... perties, and in vivo efficacy.
@en
type
label
An improved small-molecule inh ...... perties, and in vivo efficacy.
@ast
An improved small-molecule inh ...... perties, and in vivo efficacy.
@en
prefLabel
An improved small-molecule inh ...... perties, and in vivo efficacy.
@ast
An improved small-molecule inh ...... perties, and in vivo efficacy.
@en
P2093
P2860
P356
P1476
An improved small-molecule inh ...... perties, and in vivo efficacy.
@en
P2093
Alastair Logan
Anil Srivastava
Anju Yadav
David J Haydon
Hilary Peasley
Ian Collins
James M Bennett
Jeffrey P Mitchell
Joanne Berry
Leanne Macleod
P2860
P304
P356
10.1128/AAC.01580-12
P407
P50
P577
2012-10-31T00:00:00Z