Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer. - Wikidata - awgldk - TriplyDB

Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer.

Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer.

http://www.wikidata.org/entity/Q36510089

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Promoter hypermethylation of the SFRP2 gene is a high-frequent alteration and tumor-specific epigenetic marker in human breast cancer Prognostic relevance of Wnt-inhibitory factor-1 (WIF1) and Dickkopf-3 (DKK3) promoter methylation in human breast cancer Wnt signalling in human breast cancer: expression of the putative Wnt inhibitor Dickkopf-3 (DKK3) is frequently suppressed by promoter hypermethylation in mammary tumours A decade of exploring the cancer epigenome - biological and translational implications Mammary Development and Breast Cancer: A Wnt Perspective Activation of the canonical Wnt/β-catenin pathway in ATF3-induced mammary tumors Breast cancer epigenetics: from DNA methylation to microRNAs The role of prostate tumor overexpressed 1 in cancer progression Activation of Wnt signaling by chemically induced dimerization of LRP5 disrupts cellular homeostasis Small molecule antagonists of the Wnt/β-catenin signaling pathway target breast tumor-initiating cells in a Her2/Neu mouse model of breast cancer Secreted frizzle-related protein 2 stimulates angiogenesis via a calcineurin/NFAT signaling pathway BDNF is associated with SFRP1 expression in luminal and basal-like breast cancer cell lines and primary breast cancer tissues: a novel role in tumor suppression?Methylation and loss of Secreted Frizzled-Related Protein 3 enhances melanoma cell migration and invasion Effects of exercise training on circulating levels of Dickkpof-1 and secreted frizzled-related protein-1 in breast cancer survivors: A pilot single-blind randomized controlled trial The Discovery of Novel Biomarkers Improves Breast Cancer Intrinsic Subtype Prediction and Reconciles the Labels in the METABRIC Data Set.The internally truncated LRP5 receptor presents a therapeutic target in breast cancer Downregulation of SFRP5 expression and its inverse correlation with those of MMP-7 and MT1-MMP in gastric cancer.Human mammary cancer progression model recapitulates methylation events associated with breast premalignancy.Bisulfite Patch PCR enables multiplexed sequencing of promoter methylation across cancer samples.Positive feedback regulation between phospholipase D and Wnt signaling promotes Wnt-driven anchorage-independent growth of colorectal cancer cells.Dickkopf-related protein 2 induces G0/G1 arrest and apoptosis through suppressing Wnt/β-catenin signaling and is frequently methylated in breast cancer.The anti-aging gene KLOTHO is a novel target for epigenetic silencing in human cervical carcinoma GATA6 activates Wnt signaling in pancreatic cancer by negatively regulating the Wnt antagonist Dickkopf-1.DNAJB6 induces degradation of beta-catenin and causes partial reversal of mesenchymal phenotype.Epigenetic silencing of the WNT antagonist Dickkopf 3 disrupts normal Wnt/β-catenin signalling and apoptosis regulation in breast cancer cells Transcriptional silencing of the Wnt-antagonist DKK1 by promoter methylation is associated with enhanced Wnt signaling in advanced multiple myeloma Wnt signaling in cancer Wnt and mammary stem cells: hormones cannot fly wingless.Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation.Fibroblast growth factor receptor signaling dramatically accelerates tumorigenesis and enhances oncoprotein translation in the mouse mammary tumor virus-Wnt-1 mouse model of breast cancer.Key signaling nodes in mammary gland development and cancer: β-catenin.Association between folate levels and CpG Island hypermethylation in normal colorectal mucosa Lysine-specific demethylase 1 (LSD1/KDM1A) contributes to colorectal tumorigenesis via activation of the Wnt/β-catenin pathway by down-regulating Dickkopf-1 (DKK1) [corrected].A novel lung metastasis signature links Wnt signaling with cancer cell self-renewal and epithelial-mesenchymal transition in basal-like breast cancer.FastDMA: an infinium humanmethylation450 beadchip analyzer.DEAD-box protein p68 is regulated by β-catenin/transcription factor 4 to maintain a positive feedback loop in control of breast cancer progression Mammary cells with active Wnt signaling resist ErbB2-induced tumorigenesis Promoter methylation of Wnt antagonists DKK1 and SFRP1 is associated with opposing tumor subtypes in two large populations of colorectal cancer patients.Wnt-β-catenin-Tcf-4 signalling-modulated invasiveness is dependent on osteopontin expression in breast cancer.Generation of tumor-initiating cells by exogenous delivery of OCT4 transcription factor.

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Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer.

http://www.wikidata.org/entity/Q36510089

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer.

@ast

Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer.

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type

label

Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer.

@ast

Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer.

@en

prefLabel

Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer.

@ast

Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer.

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British Journal of Cancer

P1476

Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer.

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E Gabrielson

http://www.w3.org/2001/XMLSchema#string

H Carraway

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H Suzuki

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K Hirata

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K Imai

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M Mori

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M Nojima

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M Toyota

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N Nishikawa

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S B Baylin

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P2860

Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC

Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue

Transcriptional silencing of the Dickkopfs-3 (Dkk-3) gene by CpG hypermethylation in acute lymphoblastic leukaemia

Epigenetic inactivation of CHFR in human tumors

Wnt signaling and cancer

WNT pathway and mammary carcinogenesis: loss of expression of candidate tumor suppressor gene SFRP1 in most invasive carcinomas except of the medullary type

Deletions of chromosome 8p and loss of sFRP1 expression are progression markers of papillary bladder cancer

Functional epigenomics identifies genes frequently silenced in prostate cancer

Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer

Transcriptional silencing of secreted frizzled related protein 1 (SFRP 1) by promoter hypermethylation in non-small-cell lung cancer

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10.1038/SJ.BJC.6604259

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6

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5569519

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1052069862

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