Lentiviral transduction of mammary stem cells for analysis of gene function during development and cancer
about
ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epitheliumNBR1 enables autophagy-dependent focal adhesion turnoverUsing CRISPR/Cas to study gene function and model disease in vivoHistone demethylase jumonji AT-rich interactive domain 1B (JARID1B) controls mammary gland development by regulating key developmental and lineage specification genesZeppo1 is a novel metastasis promoter that represses E-cadherin expression and regulates p120-catenin isoform expression and localizationMammary morphogenesis and regeneration require the inhibition of EMT at terminal end buds by Ovol2 transcriptional repressorDeregulation of the Hippo pathway in mouse mammary stem cells promotes mammary tumorigenesis.The Par3/aPKC interaction is essential for end bud remodeling and progenitor differentiation during mammary gland morphogenesis.A microRNA miR-34a-regulated bimodal switch targets Notch in colon cancer stem cells.A novel mouse model for non-invasive single marker tracking of mammary stem cells in vivo reveals stem cell dynamics throughout pregnancyTranscriptome analysis of mammary epithelial subpopulations identifies novel determinants of lineage commitment and cell fate.Aldehyde dehydrogenase and estrogen receptor define a hierarchy of cellular differentiation in the normal human mammary epithelium.A dominant mutant allele of the ING4 tumor suppressor found in human cancer cells exacerbates MYC-initiated mouse mammary tumorigenesis.Cyclin D1 and C/EBPβ LAP1 operate in a common pathway to promote mammary epithelial cell differentiationGenetic drivers of metastatic dissemination in sonic hedgehog medulloblastomaPatient-derived xenograft models: an emerging platform for translational cancer researchR-spondin1 is a novel hormone mediator for mammary stem cell self-renewalDevelopment of an efficient, non-viral transfection method for studying gene function and bone growth in human primary cranial suture mesenchymal cells reveals that the cells respond to BMP2 and BMP3.The p16(INK4A) tumor suppressor regulates cellular oxidative stressCCAAT/enhancer binding protein beta regulates stem cell activity and specifies luminal cell fate in the mammary gland.A nontranscriptional role for Oct4 in the regulation of mitotic entrymiR-142 regulates the tumorigenicity of human breast cancer stem cells through the canonical WNT signaling pathway.Ex-vivo gene therapy restores LEKTI activity and corrects the architecture of Netherton syndrome-derived skin graftsMethods for preparing fluorescent and neutral red-stained whole mounts of mouse mammary glandsMurine mammary epithelial stem cells: discovery, function, and current status.Altered differentiation and paracrine stimulation of mammary epithelial cell proliferation by conditionally activated Smoothened.Dioxin exposure blocks lactation through a direct effect on mammary epithelial cells mediated by the aryl hydrocarbon receptor repressorRor2 regulates branching, differentiation, and actin-cytoskeletal dynamics within the mammary epithelium.Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils.LIP expression is regulated by IGF-1R signaling and participates in suppression of anoikis.Modelling breast cancer requires identification and correction of a critical cell lineage-dependent transduction biascAMP and EPAC Signaling Functionally Replace OCT4 During Induced Pluripotent Stem Cell Reprogramming.Pygo2 regulates histone gene expression and H3 K56 acetylation in human mammary epithelial cells.Heparan sulfate sulfatase SULF2 regulates PDGFRα signaling and growth in human and mouse malignant gliomaProduction of transgenic calves expressing an shRNA targeting myostatin.Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrityc-Jun N-terminal kinase 2 prevents luminal cell commitment in normal mammary glands and tumors by inhibiting p53/Notch1 and breast cancer gene 1 expression.Both LRP5 and LRP6 receptors are required to respond to physiological Wnt ligands in mammary epithelial cells and fibroblasts.The Ras-like protein R-Ras2/TC21 is important for proper mammary gland development.Expression of miR-200c in claudin-low breast cancer alters stem cell functionality, enhances chemosensitivity and reduces metastatic potential.
P2860
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P2860
Lentiviral transduction of mammary stem cells for analysis of gene function during development and cancer
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Lentiviral transduction of mam ...... during development and cancer
@ast
Lentiviral transduction of mam ...... during development and cancer
@en
type
label
Lentiviral transduction of mam ...... during development and cancer
@ast
Lentiviral transduction of mam ...... during development and cancer
@en
prefLabel
Lentiviral transduction of mam ...... during development and cancer
@ast
Lentiviral transduction of mam ...... during development and cancer
@en
P2093
P2860
P1433
P1476
Lentiviral transduction of mam ...... during development and cancer
@en
P2093
Alana L Welm
Anita S Bledau
Bryan E Welm
Gerrit J P Dijkgraaf
P2860
P304
P356
10.1016/J.STEM.2007.10.002
P407
P50
P577
2008-01-01T00:00:00Z