Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia.
about
Exploiting tumor epigenetics to improve oncolytic virotherapyLSD1/CoREST is an allosteric nanoscale clamp regulated by H3-histone-tail molecular recognition.Anti-Cancer Stem-like Cell Compounds in Clinical Development - An Overview and Critical AppraisalHistone demethylase LSD1 controls the phenotypic plasticity of cancer cellsTargeting histone methyltransferases and demethylases in clinical trials for cancer therapyDNA Methylation and Chromatin Remodeling: The Blueprint of Cancer EpigeneticsRole of ND10 nuclear bodies in the chromatin repression of HSV-1Epigenetic regulators and their impact on therapy in acute myeloid leukemiaTherapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targetingFunctional Role of G9a Histone Methyltransferase in CancerMechanisms of epigenetic regulation of leukemia onset and progressionThe role of histone demethylases in cancer therapyEpigenetic regulators as promising therapeutic targets in acute myeloid leukemiaThe roles of retinoic acid and retinoic acid receptors in inducing epigenetic changesConcise review: Leukemia stem cells in personalized medicineNext generation sequencing of acute myeloid leukemia: influencing prognosis.Emerging concepts of epigenetic dysregulation in hematological malignanciesConsidering maternal dietary modulators for epigenetic regulation and programming of the fetal epigenomeKDM1 class flavin-dependent protein lysine demethylasesEpigenetic regulation of endothelial-cell-mediated vascular repairTargeting the PELP1-KDM1 axis as a potential therapeutic strategy for breast cancerLSD1 inhibition: a therapeutic strategy in cancer?Antagonistic actions of Rcor proteins regulate LSD1 activity and cellular differentiationExpanding the druggable space of the LSD1/CoREST epigenetic target: new potential binding regions for drug-like molecules, peptides, protein partners, and chromatinSynergistic re-activation of epigenetically silenced genes by combinatorial inhibition of DNMTs and LSD1 in cancer cellsPolymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural featuresLoss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia.Understanding gene regulatory mechanisms by integrating ChIP-seq and RNA-seq data: statistical solutions to biological problems.Runx1 regulation of Pu.1 corepressor/coactivator exchange identifies specific molecular targets for leukemia differentiation therapy.Influence of oncogenic transcription factors on chromatin conformation and implications in prostate cancer.Silencing of the DNA mismatch repair gene MLH1 induced by hypoxic stress in a pathway dependent on the histone demethylase LSD1Chromatin proteins and modifications as drug targets.Identification of myelin transcription factor 1 (MyT1) as a subunit of the neural cell type-specific lysine-specific demethylase 1 (LSD1) complex.Epigenetic control of gene function in schistosomes: a source of therapeutic targets?Molecular dynamics simulations indicate an induced-fit mechanism for LSD1/CoREST-H3-histone molecular recognitionThe epigenetics of epithelial-mesenchymal plasticity in cancer.Filamins but not Janus kinases are substrates of the ASB2α cullin-ring E3 ubiquitin ligase in hematopoietic cells.Inhibition of the NAD-dependent protein deacetylase SIRT2 induces granulocytic differentiation in human leukemia cells.Small-molecular modulators of cancer-associated epigenetic mechanisms.Mutations in epigenetic modifiers in the pathogenesis and therapy of acute myeloid leukemia.
P2860
Q21131237-A5903616-3658-4C95-9385-3A7EA8DC6929Q24623687-F1909F43-091C-41F8-9A2E-F86A49D1437CQ26744536-53A25F6D-4352-48E4-BA7F-A57FAFABA313Q26745452-C730F194-EDC8-43EE-8A5F-43EA31D23617Q26746038-0604E3B9-4BF9-4582-B4EE-EE3B270AE24FQ26749421-9F92A9D6-DECF-420F-A3CD-C61CB26821E5Q26751443-522DCF45-C1D4-4611-A472-0C5CBFA6BD4AQ26765402-9EE045E7-0622-4845-91C2-B3594DA084B3Q26768602-DA4F1B34-2EB0-46D7-BE4E-6E3E28C7BB72Q26781247-11780A1B-2D19-4449-98F8-EE0F6FAEF9F5Q26861785-4B6D8DDE-F388-4F84-A5D7-9BA0B25085CAQ26864687-0F4580BF-433D-4FCA-8433-A927A99B01E3Q26865149-A524A99F-AA56-467C-A38A-1F5C0BC9754CQ26866044-BEC01A94-B8E4-407E-8C99-92136B93B298Q26995268-D6708F59-5D4C-435E-9BA3-4806AA02CB85Q27690776-739BE0A0-27DD-4050-B954-BEF36C8372BFQ28074522-C31390CF-E10E-4DE9-9C5A-1AABFC5ED708Q28080961-C916EAD6-7FED-4073-98BF-6258A441C0B6Q28084876-0C161597-6A1B-4C47-BDE0-D5BD956D8CDFQ28085420-8E39DCD4-0E28-4007-A635-B4630F422B1DQ28271388-E5046E72-1578-41E5-81DC-F933E6A28250Q28274561-D4E5FF58-4860-480E-9C24-002697AB999EQ28510940-159DEBAE-860F-4525-896E-081C3C58186FQ28534702-5E089910-C8F6-4E29-92F0-9CC6175C81ACQ28536924-657E90E0-15A6-4719-8EED-B082603B21A3Q28595992-24915AE6-31B1-4B82-B55D-9CACDFEA47D5Q30313615-DC2A64D9-5DA7-47F3-A80F-276555E57F13Q30866842-3D0E8AE4-B443-443C-BD39-1FDA018D3E16Q33652165-4AEC454E-6C05-4F4F-A209-84F7441AAC66Q33675577-FCE2E65F-5CDA-4D25-8CE2-0C9210A7235CQ33954219-277C65B3-0833-40B7-91E8-E85A8A17BE7AQ34038652-C60FCFF9-0AEE-4654-8265-178BDBD02045Q34073864-459E392D-F5EF-4C47-8F55-8E9B28C2A46EQ34159188-B462B887-F7E7-4276-99A9-25742EDEF9B3Q34243848-D76C8AC8-E370-42BF-B230-3FEA64E21F3BQ34310378-50CB8307-6E14-4A02-8812-008170A60DD4Q34391842-3E907938-71E9-4D98-89F1-C08885C33CD1Q34608747-F56CA203-BFCC-453F-9F3E-04967FE5E74AQ34628002-8261A757-80B9-43F3-879D-DDE1D7050592Q34651312-1E0AAD05-5435-4BA0-8AD2-71C015B5593A
P2860
Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Inhibition of the LSD1 (KDM1A) ...... way in acute myeloid leukemia.
@ast
Inhibition of the LSD1 (KDM1A) ...... way in acute myeloid leukemia.
@en
type
label
Inhibition of the LSD1 (KDM1A) ...... way in acute myeloid leukemia.
@ast
Inhibition of the LSD1 (KDM1A) ...... way in acute myeloid leukemia.
@en
prefLabel
Inhibition of the LSD1 (KDM1A) ...... way in acute myeloid leukemia.
@ast
Inhibition of the LSD1 (KDM1A) ...... way in acute myeloid leukemia.
@en
P2093
P2860
P50
P356
P1433
P1476
Inhibition of the LSD1 (KDM1A) ...... way in acute myeloid leukemia.
@en
P2093
Alan Burnett
Andreea C Popescu
Arthur Zelent
Jean C Y Wang
Katja Hebestreit
Laurence Marton
Liqing Jin
Louise Howell
Mark D Minden
Martin Dugas
P2860
P2888
P304
P356
10.1038/NM.2661
P407
P577
2012-03-11T00:00:00Z