IL-15 as a mediator of CD4+ help for CD8+ T cell longevity and avoidance of TRAIL-mediated apoptosis.
about
Interleukin-15 biology and its therapeutic implications in cancerIL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease-associated inflammation and lymphomagenesisPotential of immunomodulatory agents as adjunct host-directed therapies for multidrug-resistant tuberculosisProspects for an influenza vaccine that induces cross-protective cytotoxic T lymphocytes.Strategies towards universal pandemic influenza vaccines.Vaccination with vif-deleted feline immunodeficiency virus provirus, GM-CSF, and TNF-alpha plasmids preserves global CD4 T lymphocyte function after challenge with FIV.IL-15 maintains T-cell survival via S-nitrosylation-mediated inhibition of caspase-3Absence of both IL-7 and IL-15 severely impairs the development of CD8 T cell response against Toxoplasma gondii.Using 3 TLR ligands as a combination adjuvant induces qualitative changes in T cell responses needed for antiviral protection in mice.New insights into the regulation of T cells by gamma(c) family cytokinesInterleukin-15 and its receptor augment dendritic cell vaccination against the neu oncogene through the induction of antibodies partially independent of CD4 help.Vaccine-induced myeloid cell population dampens protective immunity to SIVPlasmid-encoded interleukin-15 receptor alpha enhances specific immune responses induced by a DNA vaccine in vivo.Engineering superior DNA vaccines: MHC class I single chain trimers bypass antigen processing and enhance the immune response to low affinity antigens.Maturation of monocyte derived dendritic cells with OK432 boosts IL-12p70 secretion and conveys strong T-cell responses.Role of NK cells in host defense against pulmonary type A Francisella tularensis infectionInnate and adaptive immune correlates of vaccine and adjuvant-induced control of mucosal transmission of SIV in macaques.IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction, and improves survival in sepsis.Ex vivo expansion of human CD8+ T cells using autologous CD4+ T cell helpStrategies to use immune modulators in therapeutic vaccines against cancerLiver gene transfer of interkeukin-15 constructs that become part of circulating high density lipoproteins for immunotherapyDendritic cell-derived interleukin-15 is crucial for therapeutic cancer vaccine potency.Safety (toxicity), pharmacokinetics, immunogenicity, and impact on elements of the normal immune system of recombinant human IL-15 in rhesus macaques.IL-15 ex vivo overcomes CD4+ T cell deficiency for the induction of human antigen-specific CD8+ T cell responsesFunctional limitations of plasmacytoid dendritic cells limit type I interferon, T cell responses and virus control in early life.Interleukin-2 rescues helpless effector CD8+ T cells by diminishing the susceptibility to TRAIL mediated death.TLR agonists and/or IL-15 adjuvanted mucosal SIV vaccine reduced gut CD4⁺ memory T cell loss in SIVmac251-challenged rhesus macaques.Nab2 regulates secondary CD8+ T-cell responses through control of TRAIL expression.Early CD4(+) T cell help prevents partial CD8(+) T cell exhaustion and promotes maintenance of Herpes Simplex Virus 1 latency.Interleukin-15 Constrains Mucosal T Helper 17 Cell Generation: Influence of Mononuclear PhagocytesTLR-9 and IL-15 Synergy Promotes the In Vitro Clonal Expansion of Chronic Lymphocytic Leukemia B Cells.A push-pull vaccine strategy using Toll-like receptor ligands, IL-15, and blockade of negative regulation to improve the quality and quantity of T cell immune responses.An Excess of the Proinflammatory Cytokines IFN-γ and IL-12 Impairs the Development of the Memory CD8+ T Cell Response to Chlamydia trachomatis.Human Langerhans cells use an IL-15R-α/IL-15/pSTAT5-dependent mechanism to break T-cell tolerance against the self-differentiation tumor antigen WT1.NKG2D signaling on CD8⁺ T cells represses T-bet and rescues CD4-unhelped CD8⁺ T cell memory recall but not effector responsesTrauma patients' elevated tumor necrosis related apoptosis inducing ligand (TRAIL) contributes to increased T cell apoptosis.CD8 T cell memory recall is enhanced by novel direct interactions with CD4 T cells enabled by MHC class II transferred from APCs.Prognostic impact of expression of Bcl-2 and Bax genes in circulating immune cells derived from patients with head and neck carcinoma.T cells expanded in presence of IL-15 exhibit increased antioxidant capacity and innate effector molecules.The CD4⁺ T-cell help signal is transmitted from APC to CD8⁺ T-cells via CD27-CD70 interactions
P2860
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P2860
IL-15 as a mediator of CD4+ help for CD8+ T cell longevity and avoidance of TRAIL-mediated apoptosis.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
IL-15 as a mediator of CD4+ he ...... e of TRAIL-mediated apoptosis.
@ast
IL-15 as a mediator of CD4+ he ...... e of TRAIL-mediated apoptosis.
@en
type
label
IL-15 as a mediator of CD4+ he ...... e of TRAIL-mediated apoptosis.
@ast
IL-15 as a mediator of CD4+ he ...... e of TRAIL-mediated apoptosis.
@en
prefLabel
IL-15 as a mediator of CD4+ he ...... e of TRAIL-mediated apoptosis.
@ast
IL-15 as a mediator of CD4+ he ...... e of TRAIL-mediated apoptosis.
@en
P2093
P2860
P356
P1476
IL-15 as a mediator of CD4+ he ...... e of TRAIL-mediated apoptosis.
@en
P2093
Jay A Berzofsky
Liyanage P Perera
Masaki Terabe
Sangkon Oh
Thomas A Waldmann
P2860
P304
P356
10.1073/PNAS.0801003105
P407
P577
2008-03-24T00:00:00Z