Evolution-guided identification of antiviral specificity determinants in the broadly acting interferon-induced innate immunity factor MxA.
about
Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infectionAn evolutionary perspective on the broad antiviral specificity of MxAAtlantic salmon populations reveal adaptive divergence of immune related genes - a duplicated genome under selection.Comparative structural and functional analysis of orthomyxovirus polymerase cap-snatching domainsEvolutionary Analyses Suggest a Function of MxB Immunity Proteins Beyond Lentivirus RestrictionReplication of live attenuated cold-adapted H2N2 influenza virus vaccine candidates in non human primates.In vivo evasion of MxA by avian influenza viruses requires human signature in the viral nucleoprotein.Interferon-induced HERC5 is evolving under positive selection and inhibits HIV-1 particle production by a novel mechanism targeting Rev/RRE-dependent RNA nuclear export.Evolutionary insights into host-pathogen interactions from mammalian sequence data.Ancient and recent selective pressures shaped genetic diversity at AIM2-like nucleic acid sensors.Rapid evolution of PARP genes suggests a broad role for ADP-ribosylation in host-virus conflicts.Host and viral determinants of Mx2 antiretroviral activityTransfer of the amino-terminal nuclear envelope targeting domain of human MX2 converts MX1 into an HIV-1 resistance factorGenetic variation within the Mx gene of commercially selected chicken lines reveals multiple haplotypes, recombination and a protein under selection pressure.Host and viral determinants for MxB restriction of HIV-1 infection.An evolutionary analysis of antigen processing and presentation across different timescales reveals pervasive selection.The effect of species representation on the detection of positive selection in primate gene data sets.Role of nucleotide binding and GTPase domain dimerization in dynamin-like myxovirus resistance protein A for GTPase activation and antiviral activity.A triple-arginine motif in the amino-terminal domain and oligomerization are required for HIV-1 inhibition by human MX2Mx1 and Mx2 key antiviral proteins are surprisingly lost in toothed whalesImmunobiotic Bifidobacteria Strains Modulate Rotavirus Immune Response in Porcine Intestinal Epitheliocytes via Pattern Recognition Receptor Signaling.Structural analysis of tumor-related single amino acid mutations in human MxA proteinBuried Treasure: Evolutionary Perspectives on Microbial Iron Piracy.Comparative mapping of host-pathogen protein-protein interactions.Deep mutational scanning identifies sites in influenza nucleoprotein that affect viral inhibition by MxAOligomerization Requirements for MX2-Mediated Suppression of HIV-1 InfectionGenetic conflicts: the usual suspects and beyond.Mx proteins: antiviral gatekeepers that restrain the uninvited.Molecular basis for specific recognition of bacterial ligands by NAIP/NLRC4 inflammasomes.Evolution and Antiviral Specificities of Interferon-Induced Mx Proteins of Bats against Ebola, Influenza, and Other RNA Viruses.Oligomerization and GTP-binding Requirements of MxA for Viral Target Recognition and Antiviral Activity against Influenza A Virus.Interferon-Inducible GTPases in Host Resistance, Inflammation and Disease.Rapid Evolution of Primate Type 2 Immune Response Factors Linked to Asthma Susceptibility.The frenemies within: viruses, retrotransposons and plasmids that naturally infect Saccharomyces yeasts.Chemical-controlled Activation of Antiviral Myxovirus Resistance Protein 1.Functional Comparison of Mx1 from Two Different Mouse Species Reveals the Involvement of Loop L4 in the Antiviral Activity against Influenza A Viruses.Conservation and Innovation of APOBEC3A Restriction Functions during Primate Evolution.Co-immunoprecipitation of the Mouse Mx1 Protein with the Influenza A Virus Nucleoprotein.CryoEM structure of MxB reveals a novel oligomerization interface critical for HIV restriction.Genome-scale detection of positive selection in nine primates predicts human-virus evolutionary conflicts.
P2860
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P2860
Evolution-guided identification of antiviral specificity determinants in the broadly acting interferon-induced innate immunity factor MxA.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Evolution-guided identificatio ...... ed innate immunity factor MxA.
@ast
Evolution-guided identificatio ...... ed innate immunity factor MxA.
@en
type
label
Evolution-guided identificatio ...... ed innate immunity factor MxA.
@ast
Evolution-guided identificatio ...... ed innate immunity factor MxA.
@en
prefLabel
Evolution-guided identificatio ...... ed innate immunity factor MxA.
@ast
Evolution-guided identificatio ...... ed innate immunity factor MxA.
@en
P2093
P2860
P1433
P1476
Evolution-guided identificatio ...... ed innate immunity factor MxA.
@en
P2093
Corinna Patzina
Georg Kochs
Otto Haller
Patrick S Mitchell
P2860
P304
P356
10.1016/J.CHOM.2012.09.005
P577
2012-10-01T00:00:00Z