Identification of pyrazine-based TrkA inhibitors: design, synthesis, evaluation, and computational modeling studies.

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Rational Design, Synthesis and Biological Evaluation of Pyrimidine-4,6-diamine derivatives as Type-II inhibitors of FLT3 Selective Against c-KIT.Selective, C-3 Friedel-Crafts acylation to generate functionally diverse, acetylated Imidazo[1,2-]pyridine derivatives

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P2860

Identification of pyrazine-based TrkA inhibitors: design, synthesis, evaluation, and computational modeling studies.

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2014 nî lūn-bûn

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Identification of pyrazine-bas ...... omputational modeling studies.

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Identification of pyrazine-bas ...... omputational modeling studies.

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Identification of pyrazine-bas ...... omputational modeling studies.

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Identification of pyrazine-bas ...... omputational modeling studies.

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Identification of pyrazine-bas ...... omputational modeling studies.

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Identification of pyrazine-bas ...... omputational modeling studies.

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Identification of pyrazine-bas ...... omputational modeling studies.

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Andrew Ambrose

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Brendan Frett

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Hong-Yu Li

http://www.w3.org/2001/XMLSchema#string

Nick McConnell

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Yuanxiang Wang

http://www.w3.org/2001/XMLSchema#string

Zhigang Xu

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P2860

Aminopyrazine Inhibitors Binding to an Unusual Inactive Conformation of the Mitotic Kinase Nek2: SAR and Structural Characterization

Pyrazine-based Syk kinase inhibitors

The crystal structures of TrkA and TrkB suggest key regions for achieving selective inhibition

Completing the structural family portrait of the human EphB tyrosine kinase domains

Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer.

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

Trk receptors: roles in neuronal signal transduction.

Structure and chemical inhibition of the RET tyrosine kinase domain

A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences

Neurotrophins and their receptors: a convergence point for many signalling pathways

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scholarly article

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10.1039/C4MD00251B

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Identification of pyrazine-based TrkA inhibitors: design, synthesis, evaluation, and computational modeling studies.

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P2860

P2860

Identification of pyrazine-based TrkA inhibitors: design, synthesis, evaluation, and computational modeling studies.

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type

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P1433

P1476

P2093

P2860

P304

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P698

P932

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P1433

P1476

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P2860

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P577

P698

P932