Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK. - Wikidata - awgldk - TriplyDB

Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK.

Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK.

http://www.wikidata.org/entity/Q36527182

about

Pyk2 inhibition of p53 as an adaptive and intrinsic mechanism facilitating cell proliferation and survival Growth control by intracellular tension and extracellular stiffness Nuclear FAK: a new mode of gene regulation from cellular adhesions New insights into FAK function and regulation during spermatogenesis FAK in cancer: mechanistic findings and clinical applications Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium.Focal adhesion kinase plays a role in osteoblast mechanotransduction in vitro but does not affect load-induced bone formation in vivo Decreased cell adhesion promotes angiogenesis in a Pyk2-dependent manner Vascular growth responses to chronic arterial occlusion are unaffected by myeloid specific focal adhesion kinase (FAK) deletion.Regulation of Rela/p65 and endothelial cell inflammation by proline-rich tyrosine kinase 2.Macrophage motility requires distinct α5β1/FAK and α4β1/paxillin signaling events Focal adhesion kinase modulates activation of NF-kappaB by flow in endothelial cells.Proline-rich tyrosine kinase 2 (Pyk2) regulates IGF-I-induced cell motility and invasion of urothelial carcinoma cells.Functions of the FAK family kinases in T cells: beyond actin cytoskeletal rearrangement.PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments.Focal adhesion kinase can play unique and opposing roles in regulating the morphology of differentiating oligodendrocytes Targeting Pyk2 for therapeutic intervention Phosphorylation of focal adhesion kinase at Tyr397 in gastric carcinomas and its clinical significance.The Pyk2 FERM regulates Pyk2 complex formation and phosphorylation Pyk2 promotes tumor progression in multiple myeloma Role of focal adhesion tyrosine kinases in GPVI-dependent platelet activation and reactive oxygen species formation.Endothelial focal adhesion kinase mediates cancer cell homing to discrete regions of the lungs via E-selectin up-regulation.Structural and mechanistic insights into the interaction between Pyk2 and paxillin LD motifs FAK is required for c-Met/β-catenin-driven hepatocarcinogenesis.Compensatory function of Pyk2 protein in the promotion of focal adhesion kinase (FAK)-null mammary cancer stem cell tumorigenicity and metastatic activity.Understanding the roles of FAK in cancer: inhibitors, genetic models, and new insights Snail1 controls epithelial-mesenchymal lineage commitment in focal adhesion kinase-null embryonic cells.VEGF-induced vascular permeability is mediated by FAK.Novel Role of Src in Priming Pyk2 Phosphorylation.Endothelial FAK is required for tumour angiogenesis Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression.Novel Small Molecule JP-153 Targets the Src-FAK-Paxillin Signaling Complex to Inhibit VEGF-Induced Retinal Angiogenesis.Anti-metastatic action of FAK inhibitor OXA-11 in combination with VEGFR-2 signaling blockade in pancreatic neuroendocrine tumors An in silico high-throughput screen identifies potential selective inhibitors for the non-receptor tyrosine kinase Pyk2.Focal adhesion kinase contributes to proliferative potential of ErbB2 mammary tumour cells but is dispensable for ErbB2 mammary tumour induction in vivo Focal adhesion kinase is a phospho-regulated repressor of Rac and proliferation in human endothelial cells.The phosphatase PTP-PEST/PTPN12 regulates endothelial cell migration and adhesion, but not permeability, and controls vascular development and embryonic viability Supervillin-mediated suppression of p53 protein enhances cell survival.Visualizing and manipulating focal adhesion kinase regulation in live cells.Inhibition of focal adhesion kinase (FAK) activity prevents anchorage-independent ovarian carcinoma cell growth and tumor progression.

P2860

Q24313400-58023CA2-D1A1-4E0A-BDC3-3AD972B3E13C Q24632775-95662BFE-79F4-46D9-8BC5-8A9FC450CE07 Q26864184-0602A704-EE3F-4B2A-909D-06ACC68206DE Q27014164-A33D69F2-A337-4FA9-A0F3-20874C719028 Q27026533-69DF1577-A170-4912-B046-B654EEA67724 Q27324465-BE29FA84-7A6E-4AEA-8F18-C3ABE978E55D Q28483939-AE8DCBC9-4BE4-43E6-B2F0-E406339CEDB5 Q28586929-7D13298C-D992-416E-99DD-EDB137FDE4C8 Q30276705-A7623B94-865A-4B07-9ED5-773353EE562E Q30416476-58FD50D0-F5D4-4D94-90AC-0371927FBA9E Q30428574-3236EC1F-E2D3-4742-B538-4A792E158A39 Q30434583-DF11D7CE-D0CC-4510-8FAB-4EDFA26AB9E4 Q31078386-05938974-E54B-481A-BF5A-D7543DEB7B42 Q34016697-7336CD3B-56EC-4E90-AF88-223F24CAC0B3 Q34103928-4FBC8AF1-4651-4015-A2EF-B7AB23D341C0 Q34130047-83222C51-9752-478C-B4EA-B48EF0C0E9F5 Q34146883-4348CC98-5FE5-4E9B-B206-E6DB81090A5B Q34162284-8CF13BBA-2729-4799-B9F2-E3D48EB1616B Q34209351-00211920-9CCF-4A64-A28E-396BF2680CE0 Q34398382-0C1BEEEF-4D20-4A9A-BF4D-BEECE07B6FAC Q34557479-AC94C6E9-D908-4828-9496-40432A21173A Q34621279-ADA6B063-584B-4AA1-80C4-BBCF569B0C2B Q34712704-AB0FF75F-F3A2-411D-903B-181417E65A59 Q34791002-124ECF7F-BA9C-454F-9B34-6809B95E37F5 Q34998069-8291A57F-1716-44AE-A90C-1BCA7439A1F9 Q35009792-439C69E9-AA80-4B5E-86E8-51D307895F71 Q35670729-DE9BC453-F5C7-490F-A5B9-9377B07F48F1 Q35697402-9FEAD9CF-D2C0-46EE-8DF0-B92459FDF3C4 Q35920837-4D96D339-09C5-44AC-ABB2-93B7662918C4 Q36039352-D55DD21A-B6A5-4253-91EE-8D03DF9A7A07 Q36062070-3212C14D-44D4-4389-B445-56CEF77A0A34 Q36212445-EF92C19A-16F6-4FED-A3B0-09BAE689B9D8 Q36296805-0F6F13B2-F9D1-409A-817D-CF3F3308E7B2 Q36390162-C4D82B23-50B4-4860-9C16-468E1DC74900 Q36393238-3FE30160-6AA5-4ADE-B892-CF2ECA6C6795 Q36425657-28A2F9EC-B044-4FCA-84DA-CB0F885A093B Q36466850-91938983-F268-4612-86E9-95D21D6CE4A1 Q36685259-FB9BB488-488D-43ED-812E-717AE1CAD190 Q36724913-C7E3E960-1FD7-4AFB-95AE-7CD4D47600E5 Q36754457-9824D69E-CFB3-44DE-AD02-87022BBFB973

P2860

Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK.

http://www.wikidata.org/entity/Q36527182

description

2008 nî lūn-bûn

@nan

2008年の論文

@ja

2008年論文

@yue

2008年論文

@zh-hant

2008年論文

@zh-hk

2008年論文

@zh-mo

2008年論文

@zh-tw

2008年论文

@wuu

2008年论文

@zh

2008年论文

@zh-cn

name

Compensatory role for Pyk2 dur ...... lacking endothelial cell FAK.

@ast

Compensatory role for Pyk2 dur ...... lacking endothelial cell FAK.

@en

type

label

Compensatory role for Pyk2 dur ...... lacking endothelial cell FAK.

@ast

Compensatory role for Pyk2 dur ...... lacking endothelial cell FAK.

@en

prefLabel

Compensatory role for Pyk2 dur ...... lacking endothelial cell FAK.

@ast

Compensatory role for Pyk2 dur ...... lacking endothelial cell FAK.

@en

P1433

Q36527182-97E43040-3032-4F5B-AE95-327194FDADC3

P1476

Q36527182-3B9DE291-D93D-42BA-97AF-F6D12249FE1B

P2093

Q36527182-17147E29-374A-4A42-B8BA-E44686E13A98

Q36527182-21932927-76B1-4440-BD10-15BF3A346D7A

Q36527182-32CDEC3E-CDA1-456E-A53E-328A8FB52AF7

Q36527182-3FD9CA46-92A1-482F-9FAF-AC5A08BEA84D

Q36527182-4E401754-C46C-41E7-BD52-18742FB35F7C

Q36527182-9F5A0A42-CFC4-4350-975F-42B24676E6F7

Q36527182-D5FFAA53-BBAE-4FF6-A735-A4E565E38C2F

Q36527182-D84614FE-D8F9-4596-9C36-68F40436E5D0

Q36527182-EFE395B4-6450-4968-A177-8FD846DBC951

Q36527182-FE3E3459-DC6B-48C6-A6F6-E1B167237F6E

P2860

Q36527182-084BB456-83D1-4981-A4BB-57E53401345D

Q36527182-0ADF5E9C-BC64-4515-9624-CDEBB49020E1

Q36527182-1840BFD8-4A44-4B8E-A20F-9158EFD75312

Q36527182-19874252-5ABB-4968-A483-E32C2924F8D1

Q36527182-330CF4CE-B1AA-4EA5-8FA0-7E972DFD92BE

Q36527182-3716A515-EBEA-4759-B375-2F04EBF72211

Q36527182-4A441960-0174-41F9-B78E-1F4CDE8368C6

Q36527182-53029614-37A8-4AE7-8D30-9D1556FBC23B

Q36527182-557EAEA1-C3CC-4EE8-BAC7-8732307328BD

Q36527182-592938A4-4CA0-40A5-916E-9F5D09D7535D

P304

Q36527182-1CF4688B-7FDD-4DF5-9309-53A0977C0782

P31

Q36527182-97179D5C-4F26-4D60-B611-F390BE4B859D

P356

Q36527182-C92EB38C-C45C-45B0-A3D3-AB90EB42FAE3

P407

Q36527182-47936C41-3B4C-4C5C-94F0-054F53EEB672

P433

Q36527182-2648D88B-2EB8-4598-A536-F5169FF3176C

P478

Q36527182-EE3036F2-2781-4EB2-93FD-6C88C94883E1

P577

Q36527182-3C103E1D-A5E1-4122-A49D-62DB4D27E73E

P5875

Q36527182-291364D8-4179-4F5F-BEF5-36D049CFE41D

P698

Q36527182-F545DA28-987C-45D6-8B47-26A8A1DB6BFF

P921

Q36527182-ED00CE31-3BB4-4A6C-889C-39349B6B868A

P932

Q36527182-FD4D8FFD-AB6F-42D7-8929-2E5305D20D76

P356

P1433

Journal of Cell Biology

P1476

Compensatory role for Pyk2 dur ...... lacking endothelial cell FAK.

@en

P2093

David A Cheresh

http://www.w3.org/2001/XMLSchema#string

David D Schlaepfer

http://www.w3.org/2001/XMLSchema#string

Joachim R Göthert

http://www.w3.org/2001/XMLSchema#string

Jun-Lin Guan

http://www.w3.org/2001/XMLSchema#string

Kimberly M Lutu-Fuga

http://www.w3.org/2001/XMLSchema#string

Leo A Barnes

http://www.w3.org/2001/XMLSchema#string

Sara M Weis

http://www.w3.org/2001/XMLSchema#string

Ssang-Taek Lim

http://www.w3.org/2001/XMLSchema#string

Tang-Long Shen

http://www.w3.org/2001/XMLSchema#string

Xiao Lei Chen

http://www.w3.org/2001/XMLSchema#string

P2860

Integrin-regulated FAK-Src signaling in normal and cancer cells

Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271

Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK- cell migration.

Pyk2/CAKbeta tyrosine kinase activity-mediated angiogenesis of pulmonary vascular endothelial cells

Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis

Central role of calcium-dependent tyrosine kinase PYK2 in endothelial nitric oxide synthase-mediated angiogenic response and vascular function

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

Requirement of vascular integrin alpha v beta 3 for angiogenesis

Cellular characterization of a novel focal adhesion kinase inhibitor.

Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation.

P304

43-50

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1083/JCB.200710038

http://www.w3.org/2001/XMLSchema#string

P407

P433

1

http://www.w3.org/2001/XMLSchema#string

P478

181

http://www.w3.org/2001/XMLSchema#string

P577

2008-04-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

5461626

http://www.w3.org/2001/XMLSchema#string

P698

18391070

http://www.w3.org/2001/XMLSchema#string

P921

P932

2287283

http://www.w3.org/2001/XMLSchema#string